Russian Journal of Organic Chemistry, volume 57, issue 12, pages 2077-2079

Three-Component Reaction of 1H-Pyrrole-2,3-diones with Malononitrile and Phthalhydrazide

Publication type: Journal Article
Publication date: 2021-12-01
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ISSN: 10704280, 16083393
Organic Chemistry
Abstract
Base-catalyzed three-component condensation of ethyl 4,5-dioxo-4,5-dihydro-1H-pyrrole-3-carboxylates with malononitrile and phthalhydrazide afforded substituted ethyl 3-amino-2-cyano-2′,5,10-trioxo-5′-phenyl-1′,2′,5,10-tetrahydrospiro[pyrazolo[1,2-b]phthalazine-1,3′-pyrrole]-4′-carboxylates which attract interest for medicinal chemistry. The reaction provides a convenient preparative method of synthesis of previously inaccessible spiro[pyrazolo[1,2-b]phthalazine-1,3′-pyrrole] heterocyclic system.
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Dmitriev M. V., Sabitov A. A., Maslivets A. N. Three-Component Reaction of 1H-Pyrrole-2,3-diones with Malononitrile and Phthalhydrazide // Russian Journal of Organic Chemistry. 2021. Vol. 57. No. 12. pp. 2077-2079.
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Dmitriev M. V., Sabitov A. A., Maslivets A. N. Three-Component Reaction of 1H-Pyrrole-2,3-diones with Malononitrile and Phthalhydrazide // Russian Journal of Organic Chemistry. 2021. Vol. 57. No. 12. pp. 2077-2079.
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TY - JOUR
DO - 10.1134/S1070428021120289
UR - https://doi.org/10.1134%2FS1070428021120289
TI - Three-Component Reaction of 1H-Pyrrole-2,3-diones with Malononitrile and Phthalhydrazide
T2 - Russian Journal of Organic Chemistry
AU - Dmitriev, Maksim V
AU - Sabitov, A A
AU - Maslivets, Andrey N
PY - 2021
DA - 2021/12/01 00:00:00
PB - Pleiades Publishing
SP - 2077-2079
IS - 12
VL - 57
SN - 1070-4280
SN - 1608-3393
ER -
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@article{2021_Dmitriev,
author = {Maksim V Dmitriev and A A Sabitov and Andrey N Maslivets},
title = {Three-Component Reaction of 1H-Pyrrole-2,3-diones with Malononitrile and Phthalhydrazide},
journal = {Russian Journal of Organic Chemistry},
year = {2021},
volume = {57},
publisher = {Pleiades Publishing},
month = {dec},
url = {https://doi.org/10.1134%2FS1070428021120289},
number = {12},
pages = {2077--2079},
doi = {10.1134/S1070428021120289}
}
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Dmitriev, Maksim V., et al. “Three-Component Reaction of 1H-Pyrrole-2,3-diones with Malononitrile and Phthalhydrazide.” Russian Journal of Organic Chemistry, vol. 57, no. 12, Dec. 2021, pp. 2077-2079. https://doi.org/10.1134%2FS1070428021120289.
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