Resistance of THP-1 Leukemia Cells Infected with Cytomegalovirus to Anti-tumor Antibiotic Doxorubicin and Restoration of the Sensitivity by Inhibitors of the PI3K/AKT/mTOR Molecular Pathway
Ya. Yu. Chernoryzh
1
,
N E Fedorova
1
,
K I Yurlov
1
,
R. A. Simonov
1
,
A B Kornev
2
,
D. S. Karpov
3
,
N F Zakirova
3
,
Ivanov A.V.
3
,
A. A. Kushch
1
,
A. L. Gintsburg
1, 4
Publication type: Journal Article
Publication date: 2019-11-01
scimago Q3
wos Q4
SJR: 0.223
CiteScore: 1.5
Impact factor: 0.7
ISSN: 16076729, 16083091
PubMed ID:
32130607
General Chemistry
Biochemistry
General Medicine
Biophysics
Abstract
Results obtained showed that infection with HCMV prevented the death of THP-1 cells treated with DOX in both active and latent forms of infection. In the presence of mTOR inhibitors (rapamycin and Torin2), the sensitivity of the infected cells to DOX was restored. Rapamycin inhibited the expression of the HCMV protein IE1-p72 and increased sensitivity to DOX. Molecular targets for the creation of new drugs for the treatment of leukemia in patients infected with HCMV were determined.
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Chernoryzh Y. Y. et al. Resistance of THP-1 Leukemia Cells Infected with Cytomegalovirus to Anti-tumor Antibiotic Doxorubicin and Restoration of the Sensitivity by Inhibitors of the PI3K/AKT/mTOR Molecular Pathway // Doklady Biochemistry and Biophysics. 2019. Vol. 489. No. 1. pp. 388-391.
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Chernoryzh Y. Y., Fedorova N. E., Yurlov K. I., Simonov R. A., Kornev A. B., Karpov D. S., Zakirova N. F., A.V. I., Kushch A. A., Gintsburg A. L. Resistance of THP-1 Leukemia Cells Infected with Cytomegalovirus to Anti-tumor Antibiotic Doxorubicin and Restoration of the Sensitivity by Inhibitors of the PI3K/AKT/mTOR Molecular Pathway // Doklady Biochemistry and Biophysics. 2019. Vol. 489. No. 1. pp. 388-391.
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TY - JOUR
DO - 10.1134/S1607672919060073
UR - https://doi.org/10.1134/S1607672919060073
TI - Resistance of THP-1 Leukemia Cells Infected with Cytomegalovirus to Anti-tumor Antibiotic Doxorubicin and Restoration of the Sensitivity by Inhibitors of the PI3K/AKT/mTOR Molecular Pathway
T2 - Doklady Biochemistry and Biophysics
AU - Chernoryzh, Ya. Yu.
AU - Fedorova, N E
AU - Yurlov, K I
AU - Simonov, R. A.
AU - Kornev, A B
AU - Karpov, D. S.
AU - Zakirova, N F
AU - A.V., Ivanov
AU - Kushch, A. A.
AU - Gintsburg, A. L.
PY - 2019
DA - 2019/11/01
PB - Pleiades Publishing
SP - 388-391
IS - 1
VL - 489
PMID - 32130607
SN - 1607-6729
SN - 1608-3091
ER -
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BibTex (up to 50 authors)
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@article{2019_Chernoryzh,
author = {Ya. Yu. Chernoryzh and N E Fedorova and K I Yurlov and R. A. Simonov and A B Kornev and D. S. Karpov and N F Zakirova and Ivanov A.V. and A. A. Kushch and A. L. Gintsburg},
title = {Resistance of THP-1 Leukemia Cells Infected with Cytomegalovirus to Anti-tumor Antibiotic Doxorubicin and Restoration of the Sensitivity by Inhibitors of the PI3K/AKT/mTOR Molecular Pathway},
journal = {Doklady Biochemistry and Biophysics},
year = {2019},
volume = {489},
publisher = {Pleiades Publishing},
month = {nov},
url = {https://doi.org/10.1134/S1607672919060073},
number = {1},
pages = {388--391},
doi = {10.1134/S1607672919060073}
}
Cite this
MLA
Copy
Chernoryzh, Ya. Yu., et al. “Resistance of THP-1 Leukemia Cells Infected with Cytomegalovirus to Anti-tumor Antibiotic Doxorubicin and Restoration of the Sensitivity by Inhibitors of the PI3K/AKT/mTOR Molecular Pathway.” Doklady Biochemistry and Biophysics, vol. 489, no. 1, Nov. 2019, pp. 388-391. https://doi.org/10.1134/S1607672919060073.