Doklady Biochemistry and Biophysics

, том 489 , издание 1 , страницы 388-391

Resistance of THP-1 Leukemia Cells Infected with Cytomegalovirus to Anti-tumor Antibiotic Doxorubicin and Restoration of the Sensitivity by Inhibitors of the PI3K/AKT/mTOR Molecular Pathway

Тип публикации: Journal Article

Дата публикации: 2019-11-01

Pleiades Publishing

Doklady Biochemistry and Biophysics

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white level БС3

SJR: 0.223

CiteScore: 1.5

Impact factor: 0.7

ISSN: 16076729, 16083091

DOI: 10.1134/S1607672919060073

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PubMed ID: 32130607

General Chemistry

Biochemistry

General Medicine

Biophysics

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Results obtained showed that infection with HCMV prevented the death of THP-1 cells treated with DOX in both active and latent forms of infection. In the presence of mTOR inhibitors (rapamycin and Torin2), the sensitivity of the infected cells to DOX was restored. Rapamycin inhibited the expression of the HCMV protein IE1-p72 and increased sensitivity to DOX. Molecular targets for the creation of new drugs for the treatment of leukemia in patients infected with HCMV were determined.

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Журналы

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Molecular Biology	Molecular Biology, 1, 33.33% Molecular Biology 1 публикация, 33.33%
Frontiers in Cellular and Infection Microbiology	Frontiers in Cellular and Infection Microbiology, 1, 33.33% Frontiers in Cellular and Infection Microbiology 1 публикация, 33.33%
Voprosy Virusologii	Voprosy Virusologii, 1, 33.33% Voprosy Virusologii 1 публикация, 33.33%
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Pleiades Publishing	Pleiades Publishing, 1, 33.33% Pleiades Publishing 1 публикация, 33.33%
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Central Research Institute for Epidemiology	Central Research Institute for Epidemiology, 1, 33.33% Central Research Institute for Epidemiology 1 публикация, 33.33%
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Chernoryzh Y. Y. et al. Resistance of THP-1 Leukemia Cells Infected with Cytomegalovirus to Anti-tumor Antibiotic Doxorubicin and Restoration of the Sensitivity by Inhibitors of the PI3K/AKT/mTOR Molecular Pathway // Doklady Biochemistry and Biophysics. 2019. Vol. 489. No. 1. pp. 388-391.

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Chernoryzh Y. Y., Fedorova N. E., Yurlov K. I., Simonov R. A., Kornev A. B., Karpov D. S., Zakirova N. F., A.V. I., Kushch A. A., Gintsburg A. L. Resistance of THP-1 Leukemia Cells Infected with Cytomegalovirus to Anti-tumor Antibiotic Doxorubicin and Restoration of the Sensitivity by Inhibitors of the PI3K/AKT/mTOR Molecular Pathway // Doklady Biochemistry and Biophysics. 2019. Vol. 489. No. 1. pp. 388-391.

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TY - JOUR

DO - 10.1134/S1607672919060073

UR - https://doi.org/10.1134/S1607672919060073

TI - Resistance of THP-1 Leukemia Cells Infected with Cytomegalovirus to Anti-tumor Antibiotic Doxorubicin and Restoration of the Sensitivity by Inhibitors of the PI3K/AKT/mTOR Molecular Pathway

T2 - Doklady Biochemistry and Biophysics

AU - Chernoryzh, Ya. Yu.

AU - Fedorova, N E

AU - Yurlov, K I

AU - Simonov, R. A.

AU - Kornev, A B

AU - Karpov, D. S.

AU - Zakirova, N F

AU - A.V., Ivanov

AU - Kushch, A. A.

AU - Gintsburg, A. L.

PY - 2019

DA - 2019/11/01

PB - Pleiades Publishing

SP - 388-391

IS - 1

VL - 489

PMID - 32130607

SN - 1607-6729

SN - 1608-3091

ER -

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@article{2019_Chernoryzh,

author = {Ya. Yu. Chernoryzh and N E Fedorova and K I Yurlov and R. A. Simonov and A B Kornev and D. S. Karpov and N F Zakirova and Ivanov A.V. and A. A. Kushch and A. L. Gintsburg},

title = {Resistance of THP-1 Leukemia Cells Infected with Cytomegalovirus to Anti-tumor Antibiotic Doxorubicin and Restoration of the Sensitivity by Inhibitors of the PI3K/AKT/mTOR Molecular Pathway},

journal = {Doklady Biochemistry and Biophysics},

year = {2019},

volume = {489},

publisher = {Pleiades Publishing},

month = {nov},

url = {https://doi.org/10.1134/S1607672919060073},

number = {1},

pages = {388--391},

doi = {10.1134/S1607672919060073}

}

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Chernoryzh, Ya. Yu., et al. “Resistance of THP-1 Leukemia Cells Infected with Cytomegalovirus to Anti-tumor Antibiotic Doxorubicin and Restoration of the Sensitivity by Inhibitors of the PI3K/AKT/mTOR Molecular Pathway.” Doklady Biochemistry and Biophysics, vol. 489, no. 1, Nov. 2019, pp. 388-391. https://doi.org/10.1134/S1607672919060073.