Doklady Biochemistry and Biophysics

, volume 506 , issue 1 , pages 215-219

Increasing the Efficiency of Cytochrome P450 3A4 Electrocatalysis Using Electrode Modification with Spatially Ordered Anodic Aluminum Oxide-Based Nanostructures for Investigation of Metabolic Transformations of Drugs

V V Shumyantseva ¹

P I Koroleva ²

A A Gilep ³

K. S. Napolskii ⁴

Yu D Ivanov ²

S L Kanashenko ²

A. I. Archakov ^{1, 2}

Hide authors affiliations Show authors affiliations: 4 affiliations

Pirogov Russian National Research Medical University, Moscow, Russia |

Institute of Biomedical Chemistry (IBMC), Moscow, Russia |

Institute of Bioorganic chemistry, National Academy of Sciences of Belarus, Minsk, Belarus |

⁴

Faculty of Chemistry, Moscow State University, Moscow, Russia |

Publication type: Journal Article

Publication date: 2022-10-27

Pleiades Publishing

Doklady Biochemistry and Biophysics

scimago Q3

wos Q4

SJR: 0.223

CiteScore: 1.5

Impact factor: 0.7

ISSN: 16076729, 16083091

DOI: 10.1134/S1607672922050131

Copy DOI

PubMed ID: 36303055

General Chemistry

Biochemistry

General Medicine

Biophysics

Abstract

A new approach for modifying electrodes using porous membranes based on anodic aluminum oxide with pore diameters of 0.1 and 0.2 µm and a membrane-like substance didodecyldimethylammonium bromide (DDAB) was proposed to study the electrocatalytic efficiency of the system. This approach makes it possible to increase the catalytic efficiency of the cytochrome P450 3A4-dependent N-demethylation of erythromycin by 132% when using a membrane with pore diameter of 0.1 µm and by 32% when using a membrane with 0.2 µm pore size. Electrode modification using porous membranes shifted the potential of electrochemical reduction and catalysis of cytochrome P450 3A4 in positive direction by 0.070–0.050 V, which indicates a thermodynamically more favorable process of electron transfer and enzymatic electrocatalysis.

Found

1 citation

Zvereva Maria

DSc in Chemistry, professor

102 publications, 1 299 citations

h-index: 19

Lomonosov Moscow State University

1 citation

Le-Deygen Irina

🥼 🤝

PhD in Chemistry

68 publications, 2 751 citations, 8 reviews

h-index: 19

Lomonosov Moscow State University

Research interests

Antibiotics

Chitosan

Drug delivery systems

Polymers for drug delivery

Proteins

Top-30

Journals

	1
Biosensors	Biosensors, 1, 12.5% Biosensors 1 publication, 12.5%
Processes	Processes, 1, 12.5% Processes 1 publication, 12.5%
Biomedical Chemistry Research and Methods	Biomedical Chemistry Research and Methods, 1, 12.5% Biomedical Chemistry Research and Methods 1 publication, 12.5%
Molecules	Molecules, 1, 12.5% Molecules 1 publication, 12.5%
BioNanoScience	BioNanoScience, 1, 12.5% BioNanoScience 1 publication, 12.5%
Russian Chemical Reviews	Russian Chemical Reviews, 1, 12.5% Russian Chemical Reviews 1 publication, 12.5%
Bioelectrochemistry	Bioelectrochemistry, 1, 12.5% Bioelectrochemistry 1 publication, 12.5%
Electrochimica Acta	Electrochimica Acta, 1, 12.5% Electrochimica Acta 1 publication, 12.5%
	1

Publishers

	1 2 3
MDPI	MDPI, 3, 37.5% MDPI 3 publications, 37.5%
Elsevier	Elsevier, 2, 25% Elsevier 2 publications, 25%
Institute of Biomedical Chemistry	Institute of Biomedical Chemistry, 1, 12.5% Institute of Biomedical Chemistry 1 publication, 12.5%
Springer Nature	Springer Nature, 1, 12.5% Springer Nature 1 publication, 12.5%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 12.5% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 publication, 12.5%
	1 2 3

We do not take into account publications without a DOI.
Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

Metrics

Cite this

GOST |

Cite this

GOST Copy

Shumyantseva V. V. et al. Increasing the Efficiency of Cytochrome P450 3A4 Electrocatalysis Using Electrode Modification with Spatially Ordered Anodic Aluminum Oxide-Based Nanostructures for Investigation of Metabolic Transformations of Drugs // Doklady Biochemistry and Biophysics. 2022. Vol. 506. No. 1. pp. 215-219.

GOST all authors (up to 50) Copy

Shumyantseva V. V., Koroleva P. I., Gilep A. A., Napolskii K. S., Ivanov Yu. D., Kanashenko S. L., Archakov A. I. Increasing the Efficiency of Cytochrome P450 3A4 Electrocatalysis Using Electrode Modification with Spatially Ordered Anodic Aluminum Oxide-Based Nanostructures for Investigation of Metabolic Transformations of Drugs // Doklady Biochemistry and Biophysics. 2022. Vol. 506. No. 1. pp. 215-219.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1134/S1607672922050131

UR - https://doi.org/10.1134/S1607672922050131

TI - Increasing the Efficiency of Cytochrome P450 3A4 Electrocatalysis Using Electrode Modification with Spatially Ordered Anodic Aluminum Oxide-Based Nanostructures for Investigation of Metabolic Transformations of Drugs

T2 - Doklady Biochemistry and Biophysics

AU - Shumyantseva, V V

AU - Koroleva, P I

AU - Gilep, A A

AU - Napolskii, K. S.

AU - Ivanov, Yu D

AU - Kanashenko, S L

AU - Archakov, A. I.

PY - 2022

DA - 2022/10/27

PB - Pleiades Publishing

SP - 215-219

IS - 1

VL - 506

PMID - 36303055

SN - 1607-6729

SN - 1608-3091

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2022_Shumyantseva,

author = {V V Shumyantseva and P I Koroleva and A A Gilep and K. S. Napolskii and Yu D Ivanov and S L Kanashenko and A. I. Archakov},

title = {Increasing the Efficiency of Cytochrome P450 3A4 Electrocatalysis Using Electrode Modification with Spatially Ordered Anodic Aluminum Oxide-Based Nanostructures for Investigation of Metabolic Transformations of Drugs},

journal = {Doklady Biochemistry and Biophysics},

year = {2022},

volume = {506},

publisher = {Pleiades Publishing},

month = {oct},

url = {https://doi.org/10.1134/S1607672922050131},

number = {1},

pages = {215--219},

doi = {10.1134/S1607672922050131}

}

MLA

Cite this

MLA Copy

Shumyantseva, V. V., et al. “Increasing the Efficiency of Cytochrome P450 3A4 Electrocatalysis Using Electrode Modification with Spatially Ordered Anodic Aluminum Oxide-Based Nanostructures for Investigation of Metabolic Transformations of Drugs.” Doklady Biochemistry and Biophysics, vol. 506, no. 1, Oct. 2022, pp. 215-219. https://doi.org/10.1134/S1607672922050131.