Doklady Biochemistry and Biophysics, volume 508, issue 1, pages 17-20

Barnase-barstar Specific Interaction Regulates Car-T Cells Cytotoxic Activity toward Malignancy

R S Kalinin 1
, 
V O Shipunova 1
, 
Y P Rubtsov 1
, 
V M Ukrainskay 1, 2
, 
A. Schulga 1
, 
E.V. Konovalova 1
, 
D.V. VOLKOV 1
, 
I A Yaroshevich 3
, 
A M Moysenovich 3
, 
A. A. Belogurov 1, 3
, 
G B Telegin 1
, 
A S Chernov 1
, 
M A Maschan 2
, 
S. S. Terekhov 1, 3
, 
V. D. Knorre 1
, 
E Khurs 4
, 
N. V. Gnuchev 4
, 
A. G. Gabibov 1, 3
, 
S. M. Deyev 1, 5
1
 
2
 
3
 
Moscow State University, Moscow, Russia | 
4
 
5
 
Publication type: Journal Article
Publication date: 2023-01-18
Q3
Q4
SJR: 0.242
CiteScore: 1.6
Impact factor: 0.8
ISSN: 16076729, 16083091
General Chemistry
Biochemistry
General Medicine
Biophysics
Abstract

The development of CAR-T specific therapy made a revolution in modern oncology. Despite the pronounced therapeutic effects, this novel approach displayed several crucial limitations caused by the complications in pharmacokinetics and pharmacodynamics controls. The presence of the several severe medical complications of CAR-T therapy initiated a set of attempts aimed to regulate their activity in vivo. We propose to apply the barnase-barstar system to control the cytotoxic antitumor activity of CAR-T cells. To menage the regulation targeting effect of the system we propose to use barstar-modified CAR-T cells together with barnase-based molecules. Barnase was fused with designed ankyrin repeat proteins (DARPins) specific to tumor antigens HER2 (human epidermal growth factor receptor 2) The application of the system demonstrates the pronounced regulatory effects of CAR-T targeting.

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Kalinin R. S. et al. Barnase-barstar Specific Interaction Regulates Car-T Cells Cytotoxic Activity toward Malignancy // Doklady Biochemistry and Biophysics. 2023. Vol. 508. No. 1. pp. 17-20.
GOST all authors (up to 50) Copy
Kalinin R. S., Shipunova V. O., Rubtsov Y. P., Ukrainskay V. M., Schulga A., Konovalova E., VOLKOV D., Yaroshevich I. A., Moysenovich A. M., Belogurov A. A., Telegin G. B., Chernov A. S., Maschan M. A., Terekhov S. S., Knorre V. D., Khurs E., Gnuchev N. V., Gabibov A. G., Deyev S. M. Barnase-barstar Specific Interaction Regulates Car-T Cells Cytotoxic Activity toward Malignancy // Doklady Biochemistry and Biophysics. 2023. Vol. 508. No. 1. pp. 17-20.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1134/s1607672922700041
UR - https://link.springer.com/10.1134/S1607672922700041
TI - Barnase-barstar Specific Interaction Regulates Car-T Cells Cytotoxic Activity toward Malignancy
T2 - Doklady Biochemistry and Biophysics
AU - Kalinin, R S
AU - Shipunova, V O
AU - Rubtsov, Y P
AU - Ukrainskay, V M
AU - Schulga, A.
AU - Konovalova, E.V.
AU - VOLKOV, D.V.
AU - Yaroshevich, I A
AU - Moysenovich, A M
AU - Belogurov, A. A.
AU - Telegin, G B
AU - Chernov, A S
AU - Maschan, M A
AU - Terekhov, S. S.
AU - Knorre, V. D.
AU - Khurs, E
AU - Gnuchev, N. V.
AU - Gabibov, A. G.
AU - Deyev, S. M.
PY - 2023
DA - 2023/01/18
PB - Pleiades Publishing
SP - 17-20
IS - 1
VL - 508
SN - 1607-6729
SN - 1608-3091
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2023_Kalinin,
author = {R S Kalinin and V O Shipunova and Y P Rubtsov and V M Ukrainskay and A. Schulga and E.V. Konovalova and D.V. VOLKOV and I A Yaroshevich and A M Moysenovich and A. A. Belogurov and G B Telegin and A S Chernov and M A Maschan and S. S. Terekhov and V. D. Knorre and E Khurs and N. V. Gnuchev and A. G. Gabibov and S. M. Deyev},
title = {Barnase-barstar Specific Interaction Regulates Car-T Cells Cytotoxic Activity toward Malignancy},
journal = {Doklady Biochemistry and Biophysics},
year = {2023},
volume = {508},
publisher = {Pleiades Publishing},
month = {jan},
url = {https://link.springer.com/10.1134/S1607672922700041},
number = {1},
pages = {17--20},
doi = {10.1134/s1607672922700041}
}
MLA
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MLA Copy
Kalinin, R. S., et al. “Barnase-barstar Specific Interaction Regulates Car-T Cells Cytotoxic Activity toward Malignancy.” Doklady Biochemistry and Biophysics, vol. 508, no. 1, Jan. 2023, pp. 17-20. https://link.springer.com/10.1134/S1607672922700041.
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