Doklady Biochemistry and Biophysics, volume 514, issue 1, pages 6-10
Immunoliposomes As a Promising Antiviral Agent against SARS-CoV-2
T. V. Bobik
1
,
M A Simonova
1
,
N. U. Rushkevich
1
,
N N Kostin
1
,
G A Skryabin
1
,
V. D. Knorre
1
,
A A Schulga
1
,
E.V. Konovalova
1
,
G M Proshkina
1
,
A. G. Gabibov
1, 2
,
S M Deev
1, 3
Publication type: Journal Article
Publication date: 2024-01-07
Journal:
Doklady Biochemistry and Biophysics
Quartile SCImago
Q3
Quartile WOS
Q4
Impact factor: 0.8
ISSN: 16076729, 16083091
General Chemistry
Biochemistry
General Medicine
Biophysics
Abstract
According to the World Health Organization, as of January 3, 2020 to September 13, 2023, there were approximately 23 million confirmed cases of COVID-19 reported in the Russian Federation, about 400 thousand of which were fatal. Considering the high rate of mutation of the RNA-containing virus genome, which inevitably leads to the emergence of new infectious strains (Eris and Pyrola), the search for medicinal antiviral agents remains an urgent task. Moreover, taking into account the actively mutating receptor-binding domain, this task requires fundamentally new solutions. This study proposes a candidate immunoliposomal drug that targets the S protein of SARS-CoV-2 by the monoclonal neutralizing antibody P4A1 and ensures the penetration of a highly active ribonuclease into the virus-infected cell, which degrades, among cellular RNA, viral RNA too. We demonstrate a more than 40-fold increase in the neutralizing activity of the developed drug compared to the free monoclonal neutralizing antibody.
Top-30
Citations by journals
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Russian Chemical Reviews
1 publication, 100%
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Citations by publishers
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 100%
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Bobik T. V. et al. Immunoliposomes As a Promising Antiviral Agent against SARS-CoV-2 // Doklady Biochemistry and Biophysics. 2024. Vol. 514. No. 1. pp. 6-10.
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Bobik T. V., Simonova M. A., Rushkevich N. U., Kostin N. N., Skryabin G. A., Knorre V. D., Schulga A. A., Konovalova E., Proshkina G. M., Gabibov A. G., Deev S. M. Immunoliposomes As a Promising Antiviral Agent against SARS-CoV-2 // Doklady Biochemistry and Biophysics. 2024. Vol. 514. No. 1. pp. 6-10.
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TY - JOUR
DO - 10.1134/s1607672923700618
UR - https://doi.org/10.1134/s1607672923700618
TI - Immunoliposomes As a Promising Antiviral Agent against SARS-CoV-2
T2 - Doklady Biochemistry and Biophysics
AU - Bobik, T. V.
AU - Simonova, M A
AU - Rushkevich, N. U.
AU - Kostin, N N
AU - Skryabin, G A
AU - Knorre, V. D.
AU - Schulga, A A
AU - Konovalova, E.V.
AU - Proshkina, G M
AU - Gabibov, A. G.
AU - Deev, S M
PY - 2024
DA - 2024/01/07 00:00:00
PB - Pleiades Publishing
SP - 6-10
IS - 1
VL - 514
SN - 1607-6729
SN - 1608-3091
ER -
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@article{2024_Bobik,
author = {T. V. Bobik and M A Simonova and N. U. Rushkevich and N N Kostin and G A Skryabin and V. D. Knorre and A A Schulga and E.V. Konovalova and G M Proshkina and A. G. Gabibov and S M Deev},
title = {Immunoliposomes As a Promising Antiviral Agent against SARS-CoV-2},
journal = {Doklady Biochemistry and Biophysics},
year = {2024},
volume = {514},
publisher = {Pleiades Publishing},
month = {jan},
url = {https://doi.org/10.1134/s1607672923700618},
number = {1},
pages = {6--10},
doi = {10.1134/s1607672923700618}
}
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Bobik, T. V., et al. “Immunoliposomes As a Promising Antiviral Agent against SARS-CoV-2.” Doklady Biochemistry and Biophysics, vol. 514, no. 1, Jan. 2024, pp. 6-10. https://doi.org/10.1134/s1607672923700618.
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