Evaluation of the vasculogenic potential of hydrogels based on modified fibrin
A I Shpichka
1
,
A V Koroleva
2
,
A. Deiwick
2
,
P S Timashev
3, 4
,
E F Semenova
1
,
I Ya Moiseeva
1
,
M A Konoplyannikov
5
,
B N Chichkov
2
2
Laser Zentrum Hannover E.V., Hannover, Germany
|
3
4
Publication type: Journal Article
Publication date: 2017-01-01
scimago Q4
SJR: 0.154
CiteScore: 0.6
Impact factor: —
ISSN: 1990519X, 19905203
Cell Biology
Abstract
The engineering of blood vessels that could ensure efficient transport of various nutrients and metabolites is a challenge in tissue engineering. The creation of cell-seeded bioconstructs using modified natural polymers, in particular, PEGylated fibrin is under investigation, which will help overcome this problem. Therefore, the purpose of this study was to determine the optimal ratio of the hydrogel components of modified fibrin to provide favorable conditions for the vascular development of endothelial and mesenchymal stem cell coculture. We have shown that PEGylated fibrin gels are capable of maintaining three-dimensional growth of HUVEC and hASC cells. Hydrogel with a filamentous microporous structure obtained from PEGylated 5: 1 fibrinogen and thrombin at a concentration of 0.2 U per 1 mg ensured optimal conditions for spreading, growth, and development of cocultured cells as well as the expression of proteins involved in angiogenesis.
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Total citations:
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Citations from 2024:
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MLA
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GOST
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Shpichka A. I. et al. Evaluation of the vasculogenic potential of hydrogels based on modified fibrin // Cell and Tissue Biology. 2017. Vol. 11. No. 1. pp. 81-87.
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Shpichka A. I., Koroleva A. V., Deiwick A., Timashev P. S., Semenova E. F., Moiseeva I. Ya., Konoplyannikov M. A., Chichkov B. N. Evaluation of the vasculogenic potential of hydrogels based on modified fibrin // Cell and Tissue Biology. 2017. Vol. 11. No. 1. pp. 81-87.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1134/S1990519X17010126
UR - https://doi.org/10.1134/S1990519X17010126
TI - Evaluation of the vasculogenic potential of hydrogels based on modified fibrin
T2 - Cell and Tissue Biology
AU - Shpichka, A I
AU - Koroleva, A V
AU - Deiwick, A.
AU - Timashev, P S
AU - Semenova, E F
AU - Moiseeva, I Ya
AU - Konoplyannikov, M A
AU - Chichkov, B N
PY - 2017
DA - 2017/01/01
PB - Pleiades Publishing
SP - 81-87
IS - 1
VL - 11
SN - 1990-519X
SN - 1990-5203
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2017_Shpichka,
author = {A I Shpichka and A V Koroleva and A. Deiwick and P S Timashev and E F Semenova and I Ya Moiseeva and M A Konoplyannikov and B N Chichkov},
title = {Evaluation of the vasculogenic potential of hydrogels based on modified fibrin},
journal = {Cell and Tissue Biology},
year = {2017},
volume = {11},
publisher = {Pleiades Publishing},
month = {jan},
url = {https://doi.org/10.1134/S1990519X17010126},
number = {1},
pages = {81--87},
doi = {10.1134/S1990519X17010126}
}
Cite this
MLA
Copy
Shpichka, A. I., et al. “Evaluation of the vasculogenic potential of hydrogels based on modified fibrin.” Cell and Tissue Biology, vol. 11, no. 1, Jan. 2017, pp. 81-87. https://doi.org/10.1134/S1990519X17010126.
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