,
volume 7
,
issue 1
,
pages 29-36
Resistance of cancer cells to the TRAIL-induced apoptosis in confluent cultures
Publication type: Journal Article
Publication date: 2013-01-01
scimago Q3
wos Q4
SJR: 0.336
CiteScore: 1.8
Impact factor: 1.4
ISSN: 19907478, 19907494
Biochemistry
Cell Biology
Biophysics
Abstract
TRAIL (TNF-alpha Related Apoptosis-Inducing Ligand) is an attractive candidate for anticancer therapy. TRAIL selectively kills tumor cells, without damaging normal cells. It is known that cancer cells can acquire resistance to chemotherapeutic drugs, oxidative stress in high density culture. This phenomenon appears as a multi-cell resistance, cell adhesion-dependent resistance, or density-dependent resistance of tumor cells. However, it is unclear whether such resistance appears in TRAIL-induced apoptosis. We observed that the resistance to izTRAIL of all tumor cell lines used was considerably increased in confluent cultures. The increase in tumor cell resistance in dense populations is not related to their proliferative status. It was shown that the dissociation of calcium-dependent cell-cell contacts with EGTA did not suppress tumor cell resistance to izTRAIL in confluent cultures. This phenomenon of cancer cells resistance to TRAIL-induced apoptosis should be considered in the development of methods of anticancer therapy.
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Fadeev R. S. et al. Resistance of cancer cells to the TRAIL-induced apoptosis in confluent cultures // Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology. 2013. Vol. 7. No. 1. pp. 29-36.
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Fadeev R. S., Chekanov A. V., Dolgikh N. V., Akatov V. S. Resistance of cancer cells to the TRAIL-induced apoptosis in confluent cultures // Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology. 2013. Vol. 7. No. 1. pp. 29-36.
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RIS
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TY - JOUR
DO - 10.1134/s1990747812060049
UR - https://doi.org/10.1134/s1990747812060049
TI - Resistance of cancer cells to the TRAIL-induced apoptosis in confluent cultures
T2 - Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology
AU - Fadeev, R S
AU - Chekanov, A V
AU - Dolgikh, N V
AU - Akatov, V S
PY - 2013
DA - 2013/01/01
PB - Pleiades Publishing
SP - 29-36
IS - 1
VL - 7
SN - 1990-7478
SN - 1990-7494
ER -
Cite this
BibTex (up to 50 authors)
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@article{2013_Fadeev,
author = {R S Fadeev and A V Chekanov and N V Dolgikh and V S Akatov},
title = {Resistance of cancer cells to the TRAIL-induced apoptosis in confluent cultures},
journal = {Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology},
year = {2013},
volume = {7},
publisher = {Pleiades Publishing},
month = {jan},
url = {https://doi.org/10.1134/s1990747812060049},
number = {1},
pages = {29--36},
doi = {10.1134/s1990747812060049}
}
Cite this
MLA
Copy
Fadeev, R. S., et al. “Resistance of cancer cells to the TRAIL-induced apoptosis in confluent cultures.” Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology, vol. 7, no. 1, Jan. 2013, pp. 29-36. https://doi.org/10.1134/s1990747812060049.
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