Supercritical fluid micronization of risperidone pharmaceutical substance
V. N. Bagratashvili
1
,
A.M Egorov
2
,
L I Krotova
1
,
A.V. Mironov
1
,
V Ya Panchenko
1
,
O.O. Parenago
3
,
V.K. Popov
1
,
I.A. Revelsky
4
,
P S Timashev
1
,
S.I. Tsypina
1
2
ZAO “Rafarma”, Moscow, Russia
|
3
Тип публикации: Journal Article
Дата публикации: 2012-12-01
scimago Q4
БС2
SJR: 0.244
CiteScore: 2.6
Impact factor: —
ISSN: 19907931, 19907923
Physical and Theoretical Chemistry
Краткое описание
A comparative study of the supercritical fluid micronization of risperidone pharmaceutical substance with an initial particle size of 50 to 100 μm by the RESS and SAS methods aimed at increasing the bioavailability of risperidone as a drug was performed. Both methods makes it possible to prepare risperidone particle of various forms, 5–20 μm in size. However, the SAS method is preferable, because in contrast to RESS, it does not cause contamination of risperidone with organic solvents used in both processes or any other impurities and also makes it possible to vary the shape and size of particles. It is shown that, during SAS micronization, the polymorphic form of risperidone changes from triclinic to monoclinic.
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ГОСТ
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Bagratashvili V. N. et al. Supercritical fluid micronization of risperidone pharmaceutical substance // Russian Journal of Physical Chemistry B. 2012. Vol. 6. No. 7. pp. 804-812.
ГОСТ со всеми авторами (до 50)
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Bagratashvili V. N., Egorov A., Krotova L. I., Mironov A., Panchenko V. Ya., Parenago O., Popov V., Revelsky I., Timashev P. S., Tsypina S. Supercritical fluid micronization of risperidone pharmaceutical substance // Russian Journal of Physical Chemistry B. 2012. Vol. 6. No. 7. pp. 804-812.
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RIS
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TY - JOUR
DO - 10.1134/S1990793112070019
UR - https://doi.org/10.1134/S1990793112070019
TI - Supercritical fluid micronization of risperidone pharmaceutical substance
T2 - Russian Journal of Physical Chemistry B
AU - Bagratashvili, V. N.
AU - Egorov, A.M
AU - Krotova, L I
AU - Mironov, A.V.
AU - Panchenko, V Ya
AU - Parenago, O.O.
AU - Popov, V.K.
AU - Revelsky, I.A.
AU - Timashev, P S
AU - Tsypina, S.I.
PY - 2012
DA - 2012/12/01
PB - Pleiades Publishing
SP - 804-812
IS - 7
VL - 6
SN - 1990-7931
SN - 1990-7923
ER -
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BibTex (до 50 авторов)
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@article{2012_Bagratashvili,
author = {V. N. Bagratashvili and A.M Egorov and L I Krotova and A.V. Mironov and V Ya Panchenko and O.O. Parenago and V.K. Popov and I.A. Revelsky and P S Timashev and S.I. Tsypina},
title = {Supercritical fluid micronization of risperidone pharmaceutical substance},
journal = {Russian Journal of Physical Chemistry B},
year = {2012},
volume = {6},
publisher = {Pleiades Publishing},
month = {dec},
url = {https://doi.org/10.1134/S1990793112070019},
number = {7},
pages = {804--812},
doi = {10.1134/S1990793112070019}
}
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MLA
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Bagratashvili, V. N., et al. “Supercritical fluid micronization of risperidone pharmaceutical substance.” Russian Journal of Physical Chemistry B, vol. 6, no. 7, Dec. 2012, pp. 804-812. https://doi.org/10.1134/S1990793112070019.