Russian Journal of Physical Chemistry B

, volume 12 , issue 8 , pages 1240-1248

Micronization of Salbutamol Sulfate by Supercritical Antisolvent Precipitation: The Effect of Process Parameters on the Size and Morphology of Particles

A. M. Vorobei ^{1, 2}

O I Pokrovskiy ¹

K B Ustinovich ¹

O.O. Parenago ^{1, 2}

V. V. Lunin ^{1, 2}

A G Miroshnichenko ³

Hide authors affiliations Show authors affiliations: 3 affiliations

Kurnakov institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russia |

Moscow State University, Moscow, Russia |

Siberian State Medical University, Tomsk, Russia |

Publication type: Journal Article

Publication date: 2018-12-01

Pleiades Publishing

Russian Journal of Physical Chemistry B

scimago Q4

SJR: 0.244

CiteScore: 2.6

Impact factor: —

ISSN: 19907931, 19907923

DOI: 10.1134/S1990793118080146

Copy DOI

Physical and Theoretical Chemistry

Abstract

A study was made of the applicability of supercritical antisolvent precipitation to producing microparticles of the antiasthmatic drug salbutamol sulfate that are suitable for manufacturing the drug in inhalation dosage form. Depending on the salbutamol concentration in the initial solution, the flow rate of the solution, and pressure, either spherical or needle-like particles 0.7–8.5 μm in size form. The dependence of the average particle size on the salbutamol concentration in the initial solution is nonmonotonic. The conditions were determined under which the obtained salbutamol particles meet the shape and size requirements for fabrication of inhalation dosage forms.

Found

2 citations

Loktev Alexey

DSc in Chemistry, professor

100 publications, 875 citations, 53 reviews

h-index: 14

Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences

A.V. Topchiev Institute of Petrochemical Synthesis RAS

National University of Oil and Gas «Gubkin University»

Lomonosov Moscow State University

1 citation

Maslakov Konstantin

PhD in Physics and Mathematics

347 publications, 5 613 citations, 35 reviews

h-index: 35

Lomonosov Moscow State University

National Research Centre "Kurchatov Institute"

1 citation

Cherednichenko Kirill

🥼 🤝

PhD in Chemistry

82 publications, 843 citations, 6 reviews

h-index: 16

National University of Oil and Gas «Gubkin University»

Lomonosov Moscow State University

Hierarchically porous materials

Nanocomposites

Polymer composites

Refractory materials

Scanning electron microscopy

Synchrotron radiation

X-ray diffraction (XRD)

1 citation

Habriev ILNAR

PhD

40 publications, 250 citations

h-index: 9

Kazan National Research Technological University

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GOST |

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GOST Copy

Vorobei A. M. et al. Micronization of Salbutamol Sulfate by Supercritical Antisolvent Precipitation: The Effect of Process Parameters on the Size and Morphology of Particles // Russian Journal of Physical Chemistry B. 2018. Vol. 12. No. 8. pp. 1240-1248.

GOST all authors (up to 50) Copy

Vorobei A. M., Pokrovskiy O. I., Ustinovich K. B., Parenago O., Lunin V. V., Miroshnichenko A. G. Micronization of Salbutamol Sulfate by Supercritical Antisolvent Precipitation: The Effect of Process Parameters on the Size and Morphology of Particles // Russian Journal of Physical Chemistry B. 2018. Vol. 12. No. 8. pp. 1240-1248.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1134/S1990793118080146

UR - https://doi.org/10.1134/S1990793118080146

TI - Micronization of Salbutamol Sulfate by Supercritical Antisolvent Precipitation: The Effect of Process Parameters on the Size and Morphology of Particles

T2 - Russian Journal of Physical Chemistry B

AU - Vorobei, A. M.

AU - Pokrovskiy, O I

AU - Ustinovich, K B

AU - Parenago, O.O.

AU - Lunin, V. V.

AU - Miroshnichenko, A G

PY - 2018

DA - 2018/12/01

PB - Pleiades Publishing

SP - 1240-1248

IS - 8

VL - 12

SN - 1990-7931

SN - 1990-7923

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2018_Vorobei,

author = {A. M. Vorobei and O I Pokrovskiy and K B Ustinovich and O.O. Parenago and V. V. Lunin and A G Miroshnichenko},

title = {Micronization of Salbutamol Sulfate by Supercritical Antisolvent Precipitation: The Effect of Process Parameters on the Size and Morphology of Particles},

journal = {Russian Journal of Physical Chemistry B},

year = {2018},

volume = {12},

publisher = {Pleiades Publishing},

month = {dec},

url = {https://doi.org/10.1134/S1990793118080146},

number = {8},

pages = {1240--1248},

doi = {10.1134/S1990793118080146}

}

MLA

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MLA Copy

Vorobei, A. M., et al. “Micronization of Salbutamol Sulfate by Supercritical Antisolvent Precipitation: The Effect of Process Parameters on the Size and Morphology of Particles.” Russian Journal of Physical Chemistry B, vol. 12, no. 8, Dec. 2018, pp. 1240-1248. https://doi.org/10.1134/S1990793118080146.

Publisher

Pleiades Publishing

Journal

Russian Journal of Physical Chemistry B

scimago Q4

SJR

0.244

CiteScore

2.6

Impact factor

—

ISSN

19907931 (Print)

19907923 (Electronic)

Profiles

Olga O Parenago