Micronization of Salbutamol Sulfate by Supercritical Antisolvent Precipitation: The Effect of Process Parameters on the Size and Morphology of Particles
Тип публикации: Journal Article
Дата публикации: 2018-12-01
scimago Q4
white level БС2
SJR: 0.244
CiteScore: 2.6
Impact factor: 1.4
ISSN: 19907931, 19907923
Physical and Theoretical Chemistry
Краткое описание
A study was made of the applicability of supercritical antisolvent precipitation to producing microparticles of the antiasthmatic drug salbutamol sulfate that are suitable for manufacturing the drug in inhalation dosage form. Depending on the salbutamol concentration in the initial solution, the flow rate of the solution, and pressure, either spherical or needle-like particles 0.7–8.5 μm in size form. The dependence of the average particle size on the salbutamol concentration in the initial solution is nonmonotonic. The conditions were determined under which the obtained salbutamol particles meet the shape and size requirements for fabrication of inhalation dosage forms.
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Vorobei A. M. et al. Micronization of Salbutamol Sulfate by Supercritical Antisolvent Precipitation: The Effect of Process Parameters on the Size and Morphology of Particles // Russian Journal of Physical Chemistry B. 2018. Vol. 12. No. 8. pp. 1240-1248.
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Vorobei A. M., Pokrovskiy O. I., Ustinovich K. B., Parenago O., Lunin V. V., Miroshnichenko A. G. Micronization of Salbutamol Sulfate by Supercritical Antisolvent Precipitation: The Effect of Process Parameters on the Size and Morphology of Particles // Russian Journal of Physical Chemistry B. 2018. Vol. 12. No. 8. pp. 1240-1248.
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TY - JOUR
DO - 10.1134/S1990793118080146
UR - https://doi.org/10.1134/S1990793118080146
TI - Micronization of Salbutamol Sulfate by Supercritical Antisolvent Precipitation: The Effect of Process Parameters on the Size and Morphology of Particles
T2 - Russian Journal of Physical Chemistry B
AU - Vorobei, A. M.
AU - Pokrovskiy, O I
AU - Ustinovich, K B
AU - Parenago, O.O.
AU - Lunin, V. V.
AU - Miroshnichenko, A G
PY - 2018
DA - 2018/12/01
PB - Pleiades Publishing
SP - 1240-1248
IS - 8
VL - 12
SN - 1990-7931
SN - 1990-7923
ER -
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@article{2018_Vorobei,
author = {A. M. Vorobei and O I Pokrovskiy and K B Ustinovich and O.O. Parenago and V. V. Lunin and A G Miroshnichenko},
title = {Micronization of Salbutamol Sulfate by Supercritical Antisolvent Precipitation: The Effect of Process Parameters on the Size and Morphology of Particles},
journal = {Russian Journal of Physical Chemistry B},
year = {2018},
volume = {12},
publisher = {Pleiades Publishing},
month = {dec},
url = {https://doi.org/10.1134/S1990793118080146},
number = {8},
pages = {1240--1248},
doi = {10.1134/S1990793118080146}
}
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MLA
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Vorobei, A. M., et al. “Micronization of Salbutamol Sulfate by Supercritical Antisolvent Precipitation: The Effect of Process Parameters on the Size and Morphology of Particles.” Russian Journal of Physical Chemistry B, vol. 12, no. 8, Dec. 2018, pp. 1240-1248. https://doi.org/10.1134/S1990793118080146.
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