Russian Journal of Genetics: Applied Research, volume 7, issue 2, pages 191-194

Pharmacologic correction of paclitaxel induced gene- and myelotoxicity with an extract of the hairy root culture from Scutellaria baicalensis

O V Neupokoeva 1
, 
O L Voronova 1
, 
E P Fedorova 1
, 
M V Filonova 1, 2
, 
L A Ermolaeva 1
, 
T I Fomina 1
, 
A A Churin 1, 2
1
 
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia | 
2
 
Publication type: Journal Article
Publication date: 2017-03-23
SJR: —
CiteScore: —
Impact factor: —
ISSN: 20790597, 20790600
Genetics
Agronomy and Crop Science
Animal Science and Zoology
Abstract
The gene protection effects of the hairy transgenic root extract, obtained as a result of the transformation of Scutellaria baicalensis into Agrobacterium rhizogenes, were revealed on a model of paclitaxel induced genotoxicity in mouse bone marrow and the Drosophila melanogaster somatic cells both under acute and chronic administration at the early and late periods of the study. The stimulation of granylocyto- and erythrocytopoiesis was demonstrated for the hairy roots extract of Scutellaria baicalensis on a rat model of paclitaxel- induced myelosuppression.
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Neupokoeva O. V. et al. Pharmacologic correction of paclitaxel induced gene- and myelotoxicity with an extract of the hairy root culture from Scutellaria baicalensis // Russian Journal of Genetics: Applied Research. 2017. Vol. 7. No. 2. pp. 191-194.
GOST all authors (up to 50) Copy
Neupokoeva O. V., Voronova O. L., Fedorova E. P., Filonova M. V., Ermolaeva L. A., Fomina T. I., Churin A. A. Pharmacologic correction of paclitaxel induced gene- and myelotoxicity with an extract of the hairy root culture from Scutellaria baicalensis // Russian Journal of Genetics: Applied Research. 2017. Vol. 7. No. 2. pp. 191-194.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1134/s2079059717020095
UR - https://doi.org/10.1134/s2079059717020095
TI - Pharmacologic correction of paclitaxel induced gene- and myelotoxicity with an extract of the hairy root culture from Scutellaria baicalensis
T2 - Russian Journal of Genetics: Applied Research
AU - Neupokoeva, O V
AU - Voronova, O L
AU - Fedorova, E P
AU - Filonova, M V
AU - Ermolaeva, L A
AU - Fomina, T I
AU - Churin, A A
PY - 2017
DA - 2017/03/23
PB - Pleiades Publishing
SP - 191-194
IS - 2
VL - 7
SN - 2079-0597
SN - 2079-0600
ER -
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@article{2017_Neupokoeva,
author = {O V Neupokoeva and O L Voronova and E P Fedorova and M V Filonova and L A Ermolaeva and T I Fomina and A A Churin},
title = {Pharmacologic correction of paclitaxel induced gene- and myelotoxicity with an extract of the hairy root culture from Scutellaria baicalensis},
journal = {Russian Journal of Genetics: Applied Research},
year = {2017},
volume = {7},
publisher = {Pleiades Publishing},
month = {mar},
url = {https://doi.org/10.1134/s2079059717020095},
number = {2},
pages = {191--194},
doi = {10.1134/s2079059717020095}
}
MLA
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Neupokoeva, O. V., et al. “Pharmacologic correction of paclitaxel induced gene- and myelotoxicity with an extract of the hairy root culture from Scutellaria baicalensis.” Russian Journal of Genetics: Applied Research, vol. 7, no. 2, Mar. 2017, pp. 191-194. https://doi.org/10.1134/s2079059717020095.
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