Synthesis and neurotropic activity of 6,8-diamino derivatives of pyrano[3,4-c]pyridines
E G Paronikyan
1
,
Sh Sh Dashyan
1
,
I A Dzhagatspanyan
1
,
R. G. Paronikyan
1
,
I. M. Nazaryan
1
,
A G Akopyan
1
,
N S Minasyan
2
,
A G Ayvazyan
2
,
R. A. Tamazyan
2
,
E V Babaev
3
Publication type: Journal Article
Publication date: 2016-03-01
scimago Q4
wos Q3
SJR: 0.267
CiteScore: 1.9
Impact factor: 1.7
ISSN: 10681620, 1608330X, 15739163
Organic Chemistry
Biochemistry
Abstract
New diamino derivatives of pyrano[3,4-c]pyridines were synthesized by the pyridine ring recyclization. The presence of the intramolecular hydrogen bond in 6-[(4-methoxyphenyl)amino]-3,3-dimethyl8-methylamino-3,4-dihydro-1H-pyrano[3,4-c]pyridin-5-carbonitrile was identified by X-ray diffraction. A pharmacological study of the synthesized compounds was carried out in known tests, such as assay for antagonism induced by corazole subcutaneous injection and the open field test. The method of rotating rod was used to evaluate neurotoxicity. The diamino derivatives of pyrano[3,4-c]pyridines were found to possess neutrotropic properties. The synthesized compounds, as well as diazepam, prevent the occurrence of clonic seizures and clonic corazoleinduced convulsions in animals; however, they cause a behavior-depressing sedative effect.
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Paronikyan E. G. et al. Synthesis and neurotropic activity of 6,8-diamino derivatives of pyrano[3,4-c]pyridines // Russian Journal of Bioorganic Chemistry. 2016. Vol. 42. No. 2. pp. 215-223.
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Paronikyan E. G., Dashyan S. S., Dzhagatspanyan I. A., Paronikyan R. G., Nazaryan I. M., Akopyan A. G., Minasyan N. S., Ayvazyan A. G., Tamazyan R. A., Babaev E. V. Synthesis and neurotropic activity of 6,8-diamino derivatives of pyrano[3,4-c]pyridines // Russian Journal of Bioorganic Chemistry. 2016. Vol. 42. No. 2. pp. 215-223.
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RIS
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TY - JOUR
DO - 10.1134/s1068162016020102
UR - https://doi.org/10.1134/s1068162016020102
TI - Synthesis and neurotropic activity of 6,8-diamino derivatives of pyrano[3,4-c]pyridines
T2 - Russian Journal of Bioorganic Chemistry
AU - Paronikyan, E G
AU - Dashyan, Sh Sh
AU - Dzhagatspanyan, I A
AU - Paronikyan, R. G.
AU - Nazaryan, I. M.
AU - Akopyan, A G
AU - Minasyan, N S
AU - Ayvazyan, A G
AU - Tamazyan, R. A.
AU - Babaev, E V
PY - 2016
DA - 2016/03/01
PB - Pleiades Publishing
SP - 215-223
IS - 2
VL - 42
SN - 1068-1620
SN - 1608-330X
SN - 1573-9163
ER -
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BibTex (up to 50 authors)
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@article{2016_Paronikyan,
author = {E G Paronikyan and Sh Sh Dashyan and I A Dzhagatspanyan and R. G. Paronikyan and I. M. Nazaryan and A G Akopyan and N S Minasyan and A G Ayvazyan and R. A. Tamazyan and E V Babaev},
title = {Synthesis and neurotropic activity of 6,8-diamino derivatives of pyrano[3,4-c]pyridines},
journal = {Russian Journal of Bioorganic Chemistry},
year = {2016},
volume = {42},
publisher = {Pleiades Publishing},
month = {mar},
url = {https://doi.org/10.1134/s1068162016020102},
number = {2},
pages = {215--223},
doi = {10.1134/s1068162016020102}
}
Cite this
MLA
Copy
Paronikyan, E. G., et al. “Synthesis and neurotropic activity of 6,8-diamino derivatives of pyrano[3,4-c]pyridines.” Russian Journal of Bioorganic Chemistry, vol. 42, no. 2, Mar. 2016, pp. 215-223. https://doi.org/10.1134/s1068162016020102.