Synthesis and Antiproliferative Activity of Conjugates of Anthracycline Antibiotics with Sesquiterpene Lactones of the Elecampane
Publication type: Journal Article
Publication date: 2018-09-01
scimago Q4
wos Q3
SJR: 0.267
CiteScore: 1.9
Impact factor: 1.7
ISSN: 10681620, 1608330X, 15739163
Organic Chemistry
Biochemistry
Abstract
The daunorubicin and doxorubicin anthracycline antibiotics were modified with the Inula helenium L. sesquiterpene lactones (alantolactone, isoalantolactone, and alloalantolactone) and with their epoxy derivatives. Antiproliferative properties of these conjugates were studied on tumor and normal cell lines. The daunorubicin conjugates with the sesquiterpene lactones (isoalantolactone, allantolactone, and alloalantolactone) and with their epoxy derivatives were found to exhibit the higher activity against human tumor cell lines than the corresponding doxorubicin conjugates. The daunorubicin conjugate with epoxyisoalantolactone proved to be the most effective compound, because it was more cytotoxic than daunorubicin towards a number of cell lines, including those daunorubicin-resistant, and did not affect normal human cells.
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Total citations:
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Citations from 2025:
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(16.67%)
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GOST
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Semakov A. V. et al. Synthesis and Antiproliferative Activity of Conjugates of Anthracycline Antibiotics with Sesquiterpene Lactones of the Elecampane // Russian Journal of Bioorganic Chemistry. 2018. Vol. 44. No. 5. pp. 538-546.
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Semakov A. V., Anikina L. V., Afanasyeva S. V., Pukhov S. A., Klochkov S. G. Synthesis and Antiproliferative Activity of Conjugates of Anthracycline Antibiotics with Sesquiterpene Lactones of the Elecampane // Russian Journal of Bioorganic Chemistry. 2018. Vol. 44. No. 5. pp. 538-546.
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RIS
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TY - JOUR
DO - 10.1134/s1068162018040167
UR - https://doi.org/10.1134/s1068162018040167
TI - Synthesis and Antiproliferative Activity of Conjugates of Anthracycline Antibiotics with Sesquiterpene Lactones of the Elecampane
T2 - Russian Journal of Bioorganic Chemistry
AU - Semakov, A V
AU - Anikina, L V
AU - Afanasyeva, S V
AU - Pukhov, S A
AU - Klochkov, S G
PY - 2018
DA - 2018/09/01
PB - Pleiades Publishing
SP - 538-546
IS - 5
VL - 44
SN - 1068-1620
SN - 1608-330X
SN - 1573-9163
ER -
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BibTex (up to 50 authors)
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@article{2018_Semakov,
author = {A V Semakov and L V Anikina and S V Afanasyeva and S A Pukhov and S G Klochkov},
title = {Synthesis and Antiproliferative Activity of Conjugates of Anthracycline Antibiotics with Sesquiterpene Lactones of the Elecampane},
journal = {Russian Journal of Bioorganic Chemistry},
year = {2018},
volume = {44},
publisher = {Pleiades Publishing},
month = {sep},
url = {https://doi.org/10.1134/s1068162018040167},
number = {5},
pages = {538--546},
doi = {10.1134/s1068162018040167}
}
Cite this
MLA
Copy
Semakov, A. V., et al. “Synthesis and Antiproliferative Activity of Conjugates of Anthracycline Antibiotics with Sesquiterpene Lactones of the Elecampane.” Russian Journal of Bioorganic Chemistry, vol. 44, no. 5, Sep. 2018, pp. 538-546. https://doi.org/10.1134/s1068162018040167.