Pleiades Publishing
Russian Journal of Bioorganic Chemistry
,  volume 44 ,  issue 6 ,  pages 740-744

Antiviral Activity of Acyl Derivatives of Betulin and Betulinic and Dihydroquinopimaric Acids

O B Kazakova 1
, 
I.E Smirnova 1
, 
L.A. Baltina 1
, 
E.I. Boreko 2
, 
O.V. Savinova 2
, 
A G Pokrovskii 3
1
 
2
 
Republican Research and Practice Center for Epidemiology and Microbiology, Minsk, Belarus | 
3
 
Publication type: Journal Article
Publication date: 2018-11-01
Pleiades Publishing
scimago Q4
wos Q3
SJR: 0.267
CiteScore: 1.9
Impact factor: 1.7
ISSN: 10681620, 1608330X, 15739163
Organic Chemistry
Biochemistry
Abstract
The paper reports on the synthesis of a series of acyl derivatives of betulin and dihydroquinopimaric acid and the study of their antiviral activity against influenza A virus (H7N1), herpes simplex virus type 1 (HSV-1), ECHO 6, and HIV-1 in comparison with the activity of the previously obtained acylates and original terpenoids. It has been demonstrated that acylated betulin and betulinic acid show no advantage in inhibiting the reproduction of all the tested viruses compared with the betulic acid, while structural modifications at positions C3 and C28 of the triterpene core led to some changes in the spectrum of antiviral activity. Modification of dihydroquinopimaric acid at position C4 increased the activity of this compound against influenza virus A (H7N1).
Found 
Found 

Top-30

Journals

1
2
3
Molecules
Molecules, 3, 15%
Molecules
3 publications, 15%
Reference Series in Phytochemistry
Reference Series in Phytochemistry, 2, 10%
Reference Series in Phytochemistry
2 publications, 10%
Applied Sciences (Switzerland)
Applied Sciences (Switzerland), 2, 10%
Applied Sciences (Switzerland)
2 publications, 10%
BioMed Research International
BioMed Research International, 1, 5%
BioMed Research International
1 publication, 5%
Future Medicinal Chemistry
Future Medicinal Chemistry, 1, 5%
Future Medicinal Chemistry
1 publication, 5%
Pharmaceutics
Pharmaceutics, 1, 5%
Pharmaceutics
1 publication, 5%
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 1, 5%
European Journal of Medicinal Chemistry
1 publication, 5%
Russian Journal of Bioorganic Chemistry
Russian Journal of Bioorganic Chemistry, 1, 5%
Russian Journal of Bioorganic Chemistry
1 publication, 5%
Critical Reviews in Environmental Science and Technology
Critical Reviews in Environmental Science and Technology, 1, 5%
Critical Reviews in Environmental Science and Technology
1 publication, 5%
AIP Conference Proceedings
AIP Conference Proceedings, 1, 5%
AIP Conference Proceedings
1 publication, 5%
Studies in Natural Products Chemistry
Studies in Natural Products Chemistry, 1, 5%
Studies in Natural Products Chemistry
1 publication, 5%
Mendeleev Communications, 1, 5%
Mendeleev Communications
1 publication, 5%
Anti-Infective Agents
Anti-Infective Agents, 1, 5%
Anti-Infective Agents
1 publication, 5%
1
2
3

Publishers

1
2
3
4
5
6
MDPI
MDPI, 6, 30%
MDPI
6 publications, 30%
Elsevier
Elsevier, 3, 15%
Elsevier
3 publications, 15%
Taylor & Francis
Taylor & Francis, 2, 10%
Taylor & Francis
2 publications, 10%
Springer Nature
Springer Nature, 2, 10%
Springer Nature
2 publications, 10%
Hindawi Limited
Hindawi Limited, 1, 5%
Hindawi Limited
1 publication, 5%
Pleiades Publishing
Pleiades Publishing, 1, 5%
Pleiades Publishing
1 publication, 5%
AIP Publishing
AIP Publishing, 1, 5%
AIP Publishing
1 publication, 5%
OOO Zhurnal "Mendeleevskie Soobshcheniya", 1, 5%
OOO Zhurnal "Mendeleevskie Soobshcheniya"
1 publication, 5%
Bentham Science Publishers Ltd.
Bentham Science Publishers Ltd., 1, 5%
Bentham Science Publishers Ltd.
1 publication, 5%
1
2
3
4
5
6
  • We do not take into account publications without a DOI.
  • Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
21
Share
Cite this
GOST |
Cite this
GOST Copy
Kazakova O. B. et al. Antiviral Activity of Acyl Derivatives of Betulin and Betulinic and Dihydroquinopimaric Acids // Russian Journal of Bioorganic Chemistry. 2018. Vol. 44. No. 6. pp. 740-744.
GOST all authors (up to 50) Copy
Kazakova O. B., Smirnova I., Baltina L., Boreko E., Savinova O., Pokrovskii A. G. Antiviral Activity of Acyl Derivatives of Betulin and Betulinic and Dihydroquinopimaric Acids // Russian Journal of Bioorganic Chemistry. 2018. Vol. 44. No. 6. pp. 740-744.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1134/s1068162018050059
UR - https://doi.org/10.1134/s1068162018050059
TI - Antiviral Activity of Acyl Derivatives of Betulin and Betulinic and Dihydroquinopimaric Acids
T2 - Russian Journal of Bioorganic Chemistry
AU - Kazakova, O B
AU - Smirnova, I.E
AU - Baltina, L.A.
AU - Boreko, E.I.
AU - Savinova, O.V.
AU - Pokrovskii, A G
PY - 2018
DA - 2018/11/01
PB - Pleiades Publishing
SP - 740-744
IS - 6
VL - 44
SN - 1068-1620
SN - 1608-330X
SN - 1573-9163
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2018_Kazakova,
author = {O B Kazakova and I.E Smirnova and L.A. Baltina and E.I. Boreko and O.V. Savinova and A G Pokrovskii},
title = {Antiviral Activity of Acyl Derivatives of Betulin and Betulinic and Dihydroquinopimaric Acids},
journal = {Russian Journal of Bioorganic Chemistry},
year = {2018},
volume = {44},
publisher = {Pleiades Publishing},
month = {nov},
url = {https://doi.org/10.1134/s1068162018050059},
number = {6},
pages = {740--744},
doi = {10.1134/s1068162018050059}
}
MLA
Cite this
MLA Copy
Kazakova, O. B., et al. “Antiviral Activity of Acyl Derivatives of Betulin and Betulinic and Dihydroquinopimaric Acids.” Russian Journal of Bioorganic Chemistry, vol. 44, no. 6, Nov. 2018, pp. 740-744. https://doi.org/10.1134/s1068162018050059.