Synthesis and Biological Evaluation of Theophylline Methyl 1,3,4-Oxadiazole as Anticancer Agents
Тип публикации: Journal Article
Дата публикации: 2020-09-01
SCImago Q4
WOS Q3
БС2
SJR: 0.255
CiteScore: 1.9
Impact factor: 1.7
ISSN: 10681620, 1608330X, 15739163
Organic Chemistry
Biochemistry
Краткое описание
A series of theophylline methyl 1,3,4-oxadiazole small molecules were obtained via cyclization of theophylline-7-acetohydrazide with different benzoic acids. The compounds (IVa–j) were synthesized and characterized by using conventional methods. The new compounds obtained were evaluated for their cytotoxic effect in three different cancer lines, the activity obtained varies depending upon the structure of a molecule. The compound (IVb) and (IVf) showed promising effect than other compounds of the series. Thus, these two derivatives have the potential for developing as anticancer agents.
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Russian Journal of Bioorganic Chemistry
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Vindya K Gopinatha et al. Synthesis and Biological Evaluation of Theophylline Methyl 1,3,4-Oxadiazole as Anticancer Agents // Russian Journal of Bioorganic Chemistry. 2020. Vol. 46. No. 5. pp. 837-844.
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Vindya K Gopinatha, Ray U., Mantelingu K., Raghavan S., Rangappa K. S. Synthesis and Biological Evaluation of Theophylline Methyl 1,3,4-Oxadiazole as Anticancer Agents // Russian Journal of Bioorganic Chemistry. 2020. Vol. 46. No. 5. pp. 837-844.
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TY - JOUR
DO - 10.1134/s106816202005009x
UR - https://doi.org/10.1134/s106816202005009x
TI - Synthesis and Biological Evaluation of Theophylline Methyl 1,3,4-Oxadiazole as Anticancer Agents
T2 - Russian Journal of Bioorganic Chemistry
AU - Vindya K Gopinatha
AU - Ray, Ujjayinee
AU - Mantelingu, Kempegowda
AU - Raghavan, Sathees C.
AU - Rangappa, Kanchugarakoppal S.
PY - 2020
DA - 2020/09/01
PB - Pleiades Publishing
SP - 837-844
IS - 5
VL - 46
SN - 1068-1620
SN - 1608-330X
SN - 1573-9163
ER -
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@article{2020_Vindya K Gopinatha,
author = {Vindya K Gopinatha and Ujjayinee Ray and Kempegowda Mantelingu and Sathees C. Raghavan and Kanchugarakoppal S. Rangappa},
title = {Synthesis and Biological Evaluation of Theophylline Methyl 1,3,4-Oxadiazole as Anticancer Agents},
journal = {Russian Journal of Bioorganic Chemistry},
year = {2020},
volume = {46},
publisher = {Pleiades Publishing},
month = {sep},
url = {https://doi.org/10.1134/s106816202005009x},
number = {5},
pages = {837--844},
doi = {10.1134/s106816202005009x}
}
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MLA
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Vindya K. Gopinatha, et al. “Synthesis and Biological Evaluation of Theophylline Methyl 1,3,4-Oxadiazole as Anticancer Agents.” Russian Journal of Bioorganic Chemistry, vol. 46, no. 5, Sep. 2020, pp. 837-844. https://doi.org/10.1134/s106816202005009x.
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