Effect of Nanodispersions with Lipoic Acid and Its Esters on the Functional Activity of Neutrophils and Platelets
V A Shchelkonogov
1, 2, 3
,
A. M. Inshakova
1
,
E S Darnotuk
1
,
A. V. Shipelova
1
,
A V Chekanov
2, 3
,
O A Baranova
2, 3
,
N S Shastina
1
,
E Yu Soloveva
2
,
A I Fedin
2
Publication type: Journal Article
Publication date: 2023-11-23
scimago Q4
wos Q3
SJR: 0.267
CiteScore: 1.9
Impact factor: 1.7
ISSN: 10681620, 1608330X, 15739163
Organic Chemistry
Biochemistry
Abstract
The effect of nanodispersions with lipoic acid and its esters on the activity of lactate dehydrogenase in neutrophils and platelets has been studied. It has been shown that nanoparticles with lipoic acid and its esters decrease the activity of lactate dehydrogenase in neutrophils and platelets 1.5–2 times, which indicates that nanodispersions containing lipoic acid and its conjugates decrease the concentration of reactive oxygen species in activated neutrophils and platelets 2–3 times. Studies on the inhibition of free radical processes in neutrophils and platelets showed that the nanoforms with lipoic acid and its esters possess an antioxidant activity.
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Shchelkonogov V. A. et al. Effect of Nanodispersions with Lipoic Acid and Its Esters on the Functional Activity of Neutrophils and Platelets // Russian Journal of Bioorganic Chemistry. 2023. Vol. 49. No. 6. pp. 1319-1327.
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Shchelkonogov V. A., Inshakova A. M., Darnotuk E. S., Shipelova A. V., Chekanov A. V., Baranova O. A., Shastina N. S., Soloveva E. Yu., Fedin A. I. Effect of Nanodispersions with Lipoic Acid and Its Esters on the Functional Activity of Neutrophils and Platelets // Russian Journal of Bioorganic Chemistry. 2023. Vol. 49. No. 6. pp. 1319-1327.
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TY - JOUR
DO - 10.1134/s1068162023060122
UR - https://doi.org/10.1134/s1068162023060122
TI - Effect of Nanodispersions with Lipoic Acid and Its Esters on the Functional Activity of Neutrophils and Platelets
T2 - Russian Journal of Bioorganic Chemistry
AU - Shchelkonogov, V A
AU - Inshakova, A. M.
AU - Darnotuk, E S
AU - Shipelova, A. V.
AU - Chekanov, A V
AU - Baranova, O A
AU - Shastina, N S
AU - Soloveva, E Yu
AU - Fedin, A I
PY - 2023
DA - 2023/11/23
PB - Pleiades Publishing
SP - 1319-1327
IS - 6
VL - 49
SN - 1068-1620
SN - 1608-330X
SN - 1573-9163
ER -
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BibTex (up to 50 authors)
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@article{2023_Shchelkonogov,
author = {V A Shchelkonogov and A. M. Inshakova and E S Darnotuk and A. V. Shipelova and A V Chekanov and O A Baranova and N S Shastina and E Yu Soloveva and A I Fedin},
title = {Effect of Nanodispersions with Lipoic Acid and Its Esters on the Functional Activity of Neutrophils and Platelets},
journal = {Russian Journal of Bioorganic Chemistry},
year = {2023},
volume = {49},
publisher = {Pleiades Publishing},
month = {nov},
url = {https://doi.org/10.1134/s1068162023060122},
number = {6},
pages = {1319--1327},
doi = {10.1134/s1068162023060122}
}
Cite this
MLA
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Shchelkonogov, V. A., et al. “Effect of Nanodispersions with Lipoic Acid and Its Esters on the Functional Activity of Neutrophils and Platelets.” Russian Journal of Bioorganic Chemistry, vol. 49, no. 6, Nov. 2023, pp. 1319-1327. https://doi.org/10.1134/s1068162023060122.