Practical and Efficient Route to Dolutegravir Sodium via One-Pot Synthesis of Key Intermediate with Controlled Formation of Impurities
K Srinivasachary
1
,
D Subbareddy
1
,
C Ramadas
1
,
S K K Balaji
1
,
Y S Somannavar
1
,
Ramadevi B.
2
1
Chemical Research and Development, API Research Centre II, Aurobindo Pharma Ltd., Kandi Mandal, India
|
Publication type: Journal Article
Publication date: 2022-04-01
scimago Q4
wos Q4
SJR: 0.190
CiteScore: 1.3
Impact factor: 0.9
ISSN: 10704280, 16083393
Organic Chemistry
Abstract
An efficient, cost effective and commercially viable synthesis of dolutegravir sodium has been developed from commercially available methyl 4-methoxy-3-oxobutanote through 1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid as the key intermediate. The key features of the synthesis are lower number of synthetic steps and the use of eco-friendly and inexpensive reagents. The process has been demonstrated to meet ICH requirements on scaling up.
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Srinivasachary K. et al. Practical and Efficient Route to Dolutegravir Sodium via One-Pot Synthesis of Key Intermediate with Controlled Formation of Impurities // Russian Journal of Organic Chemistry. 2022. Vol. 58. No. 4. pp. 526-535.
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Srinivasachary K., Subbareddy D., Ramadas C., Balaji S. K. K., Somannavar Y. S., B. R. Practical and Efficient Route to Dolutegravir Sodium via One-Pot Synthesis of Key Intermediate with Controlled Formation of Impurities // Russian Journal of Organic Chemistry. 2022. Vol. 58. No. 4. pp. 526-535.
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RIS
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TY - JOUR
DO - 10.1134/s1070428022040091
UR - https://doi.org/10.1134/s1070428022040091
TI - Practical and Efficient Route to Dolutegravir Sodium via One-Pot Synthesis of Key Intermediate with Controlled Formation of Impurities
T2 - Russian Journal of Organic Chemistry
AU - Srinivasachary, K
AU - Subbareddy, D
AU - Ramadas, C
AU - Balaji, S K K
AU - Somannavar, Y S
AU - B., Ramadevi
PY - 2022
DA - 2022/04/01
PB - Pleiades Publishing
SP - 526-535
IS - 4
VL - 58
SN - 1070-4280
SN - 1608-3393
ER -
Cite this
BibTex (up to 50 authors)
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@article{2022_Srinivasachary,
author = {K Srinivasachary and D Subbareddy and C Ramadas and S K K Balaji and Y S Somannavar and Ramadevi B.},
title = {Practical and Efficient Route to Dolutegravir Sodium via One-Pot Synthesis of Key Intermediate with Controlled Formation of Impurities},
journal = {Russian Journal of Organic Chemistry},
year = {2022},
volume = {58},
publisher = {Pleiades Publishing},
month = {apr},
url = {https://doi.org/10.1134/s1070428022040091},
number = {4},
pages = {526--535},
doi = {10.1134/s1070428022040091}
}
Cite this
MLA
Copy
Srinivasachary, K., et al. “Practical and Efficient Route to Dolutegravir Sodium via One-Pot Synthesis of Key Intermediate with Controlled Formation of Impurities.” Russian Journal of Organic Chemistry, vol. 58, no. 4, Apr. 2022, pp. 526-535. https://doi.org/10.1134/s1070428022040091.