Synthesis and Antiarrhythmic and Anticonvulsant Activities of Amino Amides and Amino Esters Based on 1-(4-Fluorophenyl)- and 1-[3-(Trifluoromethyl)phenyl]cyclopentane-1-carboxylic Acids

The alkylation of 2-(4-fluorophenyl)- and 2-[3-(trifluoromethyl)phenyl]acetonitriles with 1,4-di­bromo­butane gave 1-(substituted phenyl)cyclopentane-1-carbonitriles which were hydrolyzed to the corre­sponding carboxylic acids by the action of potassium hydroxide in ethylene glycol. The resulting acids were converted to acid chlorides, and the latter reacted with N,N-dialkylaminoalkylamines, as well as with N,N-di­alkylaminoalkanols, to produce new amino amide and amino ester derivatives of 1-(4-fluorophenyl)- and 1-[3-(trifluoromethyl)phenyl]cyclopentane-1-carboxylic acids, which were characterized as hydrochlorides. The synthesized compounds were evaluated for their antiarrhythmic and anticonvulsant activities.