Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry

, том 13 , издание 1 , страницы 93-96

Chronic Alcoholism Influences the mRNA Level of the Orexin Receptor Type 1 (OX1R) in Emotiogenic Structures of the Rat Brain

M I Airapetov ^{1, 2}

E A Sekste ¹

S O Eresko ³

E R Bychkov ¹

A. A. LEBEDEV ¹

P D Shabanov ^{1, 3, 4}

Скрыть аффилиации авторов Показать аффилиации авторов: 4 аффилиации

Institute of Experimental Medicine (IEM), St. Petersburg, Russia |

St. Petersburg State Medical Pediatric University, St. Petersburg, Russia |

St. Petersburg state University, St. Petersburg, Russia |

⁴

Kirov Military Medical Academy, St. Petersburg, Russia |

Тип публикации: Journal Article

Дата публикации: 2019-01-01

Pleiades Publishing

Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry

scimago Q4

wos Q4

БС3

SJR: 0.206

CiteScore: 1.0

Impact factor: 0.4

ISSN: 19907508, 19907516

DOI: 10.1134/s1990750819010025

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Biochemistry

Clinical Biochemistry

Molecular Medicine

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Orexin and its receptors are involved in mechanisms of pathological craving to alcohol. This study has shown that the mRNA level of the orexin receptor type 1 (OX1R) significantly decreased in the prefrontal cortex in the group of chronically alcoholized (for 6 months) rats compared with intact control. The same changes in the OX1R gene expression were observed on day 1 and day 7 of alcohol withdrawal after chronic alcoholization. On the contrary, in the hippocampus, the OX1R mRNA level increased on day 1 and day 7 of alcohol withdrawal. In the ventral tegmental area, the OX1R mRNA level remained unchanged on both day 1 and day 7 of alcohol withdrawal compared with the groups of chronic alcoholization and intact control. This suggests involvement of the prefrontal cortex and hippocampus in mechanisms mediating chronic alcohol intoxication.

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Medicine in Drug Discovery	Medicine in Drug Discovery, 1, 33.33% Medicine in Drug Discovery 1 публикация, 33.33%
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry	Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 1, 33.33% Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry 1 публикация, 33.33%
Reviews on Clinical Pharmacology and Drug Therapy	Reviews on Clinical Pharmacology and Drug Therapy, 1, 33.33% Reviews on Clinical Pharmacology and Drug Therapy 1 публикация, 33.33%
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Eco-Vector LLC	Eco-Vector LLC, 1, 33.33% Eco-Vector LLC 1 публикация, 33.33%
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Airapetov M. I. et al. Chronic Alcoholism Influences the mRNA Level of the Orexin Receptor Type 1 (OX1R) in Emotiogenic Structures of the Rat Brain // Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 2019. Vol. 13. No. 1. pp. 93-96.

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Airapetov M. I., Sekste E. A., Eresko S. O., Bychkov E. R., LEBEDEV A. A., Shabanov P. D. Chronic Alcoholism Influences the mRNA Level of the Orexin Receptor Type 1 (OX1R) in Emotiogenic Structures of the Rat Brain // Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 2019. Vol. 13. No. 1. pp. 93-96.

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TY - JOUR

DO - 10.1134/s1990750819010025

UR - https://doi.org/10.1134/s1990750819010025

TI - Chronic Alcoholism Influences the mRNA Level of the Orexin Receptor Type 1 (OX1R) in Emotiogenic Structures of the Rat Brain

T2 - Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry

AU - Airapetov, M I

AU - Sekste, E A

AU - Eresko, S O

AU - Bychkov, E R

AU - LEBEDEV, A. A.

AU - Shabanov, P D

PY - 2019

DA - 2019/01/01

PB - Pleiades Publishing

SP - 93-96

IS - 1

VL - 13

SN - 1990-7508

SN - 1990-7516

ER -

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@article{2019_Airapetov,

author = {M I Airapetov and E A Sekste and S O Eresko and E R Bychkov and A. A. LEBEDEV and P D Shabanov},

title = {Chronic Alcoholism Influences the mRNA Level of the Orexin Receptor Type 1 (OX1R) in Emotiogenic Structures of the Rat Brain},

journal = {Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry},

year = {2019},

volume = {13},

publisher = {Pleiades Publishing},

month = {jan},

url = {https://doi.org/10.1134/s1990750819010025},

number = {1},

pages = {93--96},

doi = {10.1134/s1990750819010025}

}

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Airapetov, M. I., et al. “Chronic Alcoholism Influences the mRNA Level of the Orexin Receptor Type 1 (OX1R) in Emotiogenic Structures of the Rat Brain.” Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, vol. 13, no. 1, Jan. 2019, pp. 93-96. https://doi.org/10.1134/s1990750819010025.