Cytostatic tetrazole–butenolide conjugates: linking tetrazole and butenolide rings via stille coupling and biological activity of the target substances
Тип публикации: Journal Article
Дата публикации: 2009-07-24
SJR: —
CiteScore: —
Impact factor: —
ISSN: 00100765, 12126950
General Chemistry
Краткое описание
A series of tetrazoles linked to the butenolide core via benzene rings were prepared by the Stille coupling reaction of α-(tributylstannyl)butenolides and 5-(alkylsulfanyl)-1-(4-iodophenyl)tetrazoles, and the compounds were tested for antifungal and cytostatic activity. Interesting antifungal activities against the filamentous strain Absidia corymbifera, and cytostatic activities against leukemic cells HL-60 and CCRF-CEM were found. The cytostatic activity requires the presence of both the butenolide ring and the alkylsulfanyl group bound to tetrazole ring. In addition, the feasibility of Pd-coupling reactions with 5-iodotetrazoles was evaluated.
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Balšánek V. et al. Cytostatic tetrazole–butenolide conjugates: linking tetrazole and butenolide rings via stille coupling and biological activity of the target substances // Collection of Czechoslovak Chemical Communications. 2009. Vol. 74. No. 7-8. pp. 1161-1178.
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Balšánek V., Tichotová L., Kuneš J., Špulák M., Pour M., Votruba I., Buchta V. Cytostatic tetrazole–butenolide conjugates: linking tetrazole and butenolide rings via stille coupling and biological activity of the target substances // Collection of Czechoslovak Chemical Communications. 2009. Vol. 74. No. 7-8. pp. 1161-1178.
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TY - JOUR
DO - 10.1135/cccc2009040
UR - https://doi.org/10.1135/cccc2009040
TI - Cytostatic tetrazole–butenolide conjugates: linking tetrazole and butenolide rings via stille coupling and biological activity of the target substances
T2 - Collection of Czechoslovak Chemical Communications
AU - Balšánek, Vojtěch
AU - Tichotová, Lucie
AU - Kuneš, J.
AU - Špulák, Marcel
AU - Pour, Milan
AU - Votruba, Ivan
AU - Buchta, Vladimír
PY - 2009
DA - 2009/07/24
PB - Institute of Organic Chemistry & Biochemistry
SP - 1161-1178
IS - 7-8
VL - 74
SN - 0010-0765
SN - 1212-6950
ER -
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@article{2009_Balšánek,
author = {Vojtěch Balšánek and Lucie Tichotová and J. Kuneš and Marcel Špulák and Milan Pour and Ivan Votruba and Vladimír Buchta},
title = {Cytostatic tetrazole–butenolide conjugates: linking tetrazole and butenolide rings via stille coupling and biological activity of the target substances},
journal = {Collection of Czechoslovak Chemical Communications},
year = {2009},
volume = {74},
publisher = {Institute of Organic Chemistry & Biochemistry},
month = {jul},
url = {https://doi.org/10.1135/cccc2009040},
number = {7-8},
pages = {1161--1178},
doi = {10.1135/cccc2009040}
}
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MLA
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Balšánek, Vojtěch, et al. “Cytostatic tetrazole–butenolide conjugates: linking tetrazole and butenolide rings via stille coupling and biological activity of the target substances.” Collection of Czechoslovak Chemical Communications, vol. 74, no. 7-8, Jul. 2009, pp. 1161-1178. https://doi.org/10.1135/cccc2009040.
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