Journal of Neurology, Neurosurgery and Psychiatry, volume 84, issue 2, pages 188-193
Preoperative and postoperative1H-MR spectroscopy changes in frontal deep white matter and the thalamus in idiopathic normal pressure hydrocephalus
Fredrik Lundin
1, 2
,
Anders Tisell
1, 2, 3, 4
,
Göran Leijon
1, 2
,
Olof Dahlqvist Leinhard
1, 2, 3, 4
,
Leif Davidsson
1, 2
,
Anders Grönqvist
1, 2, 3, 4
,
Carsten Wikkelsø
5, 6
,
Peter Lundberg
1, 2, 3, 4
2
County Council of Östergötland
3
Center for Medical Image Science and Visualization
4
CMIV
5
Sahlgrenska Academy
Publication type: Journal Article
Publication date: 2012-11-07
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 11
ISSN: 00223050, 1468330X
Psychiatry and Mental health
Surgery
Neurology (clinical)
Abstract
Background
In a previous study we found significantly decreased N-acetyl aspartate (NAA) and total N-acetyl (tNA) groups in the thalamus of patients with idiopathic normal pressure hydrocephalus (iNPH) compared with healthy individuals (HI). No significant difference between the groups could be found in the frontal deep white matter (FDWM).
Objective
The primary aim of this study was to investigate if these metabolites in the thalamus were normalised after shunt surgery. The secondary aim was to investigate postoperative metabolic changes in FDWM.
Subjects and methods
Fourteen patients with iNPH, mean age 74 years, and 15 HI, also mean age 74 years, were examined. Assessment of a motor score (MOSs) was performed before and after shunt surgery. Absolute quantitative 1H-MR spectroscopy (1.5 T, volumes of interest 2.5–3 ml) was performed on the patients in the FDWM and in the thalamus, before and 3 months after shunt surgery, and also once on the HI. The following metabolites were analysed: tNA, NAA, total creatine, total choline (tCho), myo-inositol (mIns), glutamate and lactate concentrations. MRI volumetric calculations of the lateral ventricles were also performed.
Results
At 3 months postoperatively, we found no significant changes of tNA or NAA in the thalamus. In contrast, in the FDWM, there was a significant increase of tCho (p=0.01) and a borderline significant decrease of mIns (p=0.06). 12/14 patients were shunt responders (motor function). Median reduction of the lateral ventricle was 16%. A weak correlation between MOS and ventricular reduction was seen.
Conclusions
Normalisation of thalamic tNA and NAA could not be detected postoperatively. The increased tCho and decreased mIns in the FDWM postoperatively might relate to clinical improvement.
Top-30
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3 publications, 50%
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1 publication, 16.67%
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1 publication, 16.67%
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Wiley
1 publication, 16.67%
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- We do not take into account publications without a DOI.
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Lundin F. et al. Preoperative and postoperative1H-MR spectroscopy changes in frontal deep white matter and the thalamus in idiopathic normal pressure hydrocephalus // Journal of Neurology, Neurosurgery and Psychiatry. 2012. Vol. 84. No. 2. pp. 188-193.
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Lundin F., Tisell A., Leijon G., Leinhard O. D., Davidsson L., Grönqvist A., Wikkelsø C., Lundberg P. Preoperative and postoperative1H-MR spectroscopy changes in frontal deep white matter and the thalamus in idiopathic normal pressure hydrocephalus // Journal of Neurology, Neurosurgery and Psychiatry. 2012. Vol. 84. No. 2. pp. 188-193.
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TY - JOUR
DO - 10.1136/jnnp-2012-302190
UR - https://doi.org/10.1136/jnnp-2012-302190
TI - Preoperative and postoperative1H-MR spectroscopy changes in frontal deep white matter and the thalamus in idiopathic normal pressure hydrocephalus
T2 - Journal of Neurology, Neurosurgery and Psychiatry
AU - Lundin, Fredrik
AU - Tisell, Anders
AU - Leijon, Göran
AU - Leinhard, Olof Dahlqvist
AU - Davidsson, Leif
AU - Grönqvist, Anders
AU - Wikkelsø, Carsten
AU - Lundberg, Peter
PY - 2012
DA - 2012/11/07
PB - BMJ
SP - 188-193
IS - 2
VL - 84
SN - 0022-3050
SN - 1468-330X
ER -
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@article{2012_Lundin,
author = {Fredrik Lundin and Anders Tisell and Göran Leijon and Olof Dahlqvist Leinhard and Leif Davidsson and Anders Grönqvist and Carsten Wikkelsø and Peter Lundberg},
title = {Preoperative and postoperative1H-MR spectroscopy changes in frontal deep white matter and the thalamus in idiopathic normal pressure hydrocephalus},
journal = {Journal of Neurology, Neurosurgery and Psychiatry},
year = {2012},
volume = {84},
publisher = {BMJ},
month = {nov},
url = {https://doi.org/10.1136/jnnp-2012-302190},
number = {2},
pages = {188--193},
doi = {10.1136/jnnp-2012-302190}
}
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Lundin, Fredrik, et al. “Preoperative and postoperative1H-MR spectroscopy changes in frontal deep white matter and the thalamus in idiopathic normal pressure hydrocephalus.” Journal of Neurology, Neurosurgery and Psychiatry, vol. 84, no. 2, Nov. 2012, pp. 188-193. https://doi.org/10.1136/jnnp-2012-302190.