BMJ
Journal of NeuroInterventional Surgery
,  volume 13 ,  issue 12 ,  pages 1157-1161

Suction force rather than aspiration flow correlates with recanalization in hard clots: an in vitro study model

David Fernandez Sanchez 1, 2
, 
Daniel Garcia Sabido 1, 2
, 
Tudor G. Jovin 3, 4
, 
Helena Villanova 1, 2
, 
Tommy Andersson 5, 6, 7, 8
, 
Raul G. Nogueira 9, 10
, 
Cristophe Cognard 11, 12
, 
M. Ribo 13, 14, 15, 16
, 
Adnan H. Siddiqui 17, 18
, 
Iñaki Galve 1, 2
, 
Ofir Arad 1, 2
, 
François Salmon 1, 2
1
 
R&D
2
 
Anaconda Biomed | 
3
 
Department of Neurointerventional Surgery
4
 
Cooper University Health Care
5
 
Departments of Radiology and Neurology
6
 
AZ Groeninge
7
 
Department of Neuroradiology and Department of Clinical Neuroscience
8
 
9
 
DEPARTMENT OF NEUROLOGY
10
 
11
 
Diagnostic and Therapeutic Neuroradiology
12
 
Hôpital Purpan
13
 
Stroke Unit, Department of Neurology
14
 
Hospital Vall d'Hebron
15
 
Departament de Medicina
16
 
17
 
Departments of Neurosurgery and Radiology, Jacobs School of Medicine and Biomedical Sciences
18
 
Publication type: Journal Article
Publication date: 2021-01-29
BMJ
BMJ
scimago Q1
wos Q1
SJR: 1.634
CiteScore: 8.8
Impact factor: 4.3
ISSN: 17598478, 17598486
General Medicine
Surgery
Neurology (clinical)
Abstract
Background

ANA Advanced Neurovascular Access provides a novel funnel component designed to reduce clot fragmentation and facilitate retrieval in combination with stent-retrievers (SRs) in stroke patients by restricting flow and limiting clot shaving. In previous publications ANA presented excellent in vitro/in vivo efficacy data, especially with fibrin-rich hard clots. We aimed to determine the main physical property responsible for these results, namely suction force versus aspiration flow.

Methods

We evaluated in a bench model the suction force and flow generated by ANA and compared them to other neurovascular catheters combined with a SR (Solitaire). Aspiration flow was evaluated with a flow rate sensor while applying vacuum pressure with a pump. Suction force was determined using a tensile strength testing machine and a purposely designed tool that completely seals the device tip simulating complete occlusion by a hard clot. Suction force was defined as the force needed to separate the device from the clot under aspiration. All experiments were repeated five times, and mean values used for comparisons.

Results

Aspiration flow increased with the inner diameter of the device: ANA 1.85±0.04 mL/s, ACE68 3.74±0.05 mL/s, and 8F-Flowgate2 5.96±0.30 mL/s (P<0.001). After introducing the SR, the flow was reduced by an average of 0.57±0.12 mL/s. Due to its larger distal surface, ANA suction force (1.69±0.40 N) was significantly higher than ACE68 (0.26±0.04 N) and 8F-Flowgate2 (0.42±0.06 N) (P<0.001). After introducing the SR, suction force variation was not relevant except for ANA that increased to 2.64±0.41 N.

Conclusion

Despite lower in vitro aspiration flow, the ANA design showed a substantially higher suction force than other thrombectomy devices.

Found 
Found 

Top-30

Journals

1
2
Interventional Neuroradiology, 2, 28.57%
Interventional Neuroradiology
2 publications, 28.57%
Stroke
Stroke, 1, 14.29%
Stroke
1 publication, 14.29%
Frontiers in Medical Technology
Frontiers in Medical Technology, 1, 14.29%
Frontiers in Medical Technology
1 publication, 14.29%
Clinical Neuroradiology
Clinical Neuroradiology, 1, 14.29%
Clinical Neuroradiology
1 publication, 14.29%
Neurointervention, 1, 14.29%
Neurointervention
1 publication, 14.29%
Journal of NeuroInterventional Surgery
Journal of NeuroInterventional Surgery, 1, 14.29%
Journal of NeuroInterventional Surgery
1 publication, 14.29%
1
2

Publishers

1
Ovid Technologies (Wolters Kluwer Health)
Ovid Technologies (Wolters Kluwer Health), 1, 14.29%
Ovid Technologies (Wolters Kluwer Health)
1 publication, 14.29%
World Federation of Interventional and Therapeutic Neuroradiology (WFITN), 1, 14.29%
World Federation of Interventional and Therapeutic Neuroradiology (WFITN)
1 publication, 14.29%
Frontiers Media S.A.
Frontiers Media S.A., 1, 14.29%
Frontiers Media S.A.
1 publication, 14.29%
Springer Nature
Springer Nature, 1, 14.29%
Springer Nature
1 publication, 14.29%
Korean Society of Interventional Neuroradiology, 1, 14.29%
Korean Society of Interventional Neuroradiology
1 publication, 14.29%
BMJ
BMJ, 1, 14.29%
BMJ
1 publication, 14.29%
SAGE
SAGE, 1, 14.29%
SAGE
1 publication, 14.29%
1
  • We do not take into account publications without a DOI.
  • Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
7
Share
Cite this
GOST |
Cite this
GOST Copy
Fernandez Sanchez D. et al. Suction force rather than aspiration flow correlates with recanalization in hard clots: an in vitro study model // Journal of NeuroInterventional Surgery. 2021. Vol. 13. No. 12. pp. 1157-1161.
GOST all authors (up to 50) Copy
Fernandez Sanchez D., Garcia Sabido D., Jovin T. G., Villanova H., Andersson T., Nogueira R. G., Cognard C., Ribo M., Siddiqui A. H., Galve I., Arad O., Salmon F. Suction force rather than aspiration flow correlates with recanalization in hard clots: an in vitro study model // Journal of NeuroInterventional Surgery. 2021. Vol. 13. No. 12. pp. 1157-1161.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1136/neurintsurg-2020-017242
UR - https://doi.org/10.1136/neurintsurg-2020-017242
TI - Suction force rather than aspiration flow correlates with recanalization in hard clots: an in vitro study model
T2 - Journal of NeuroInterventional Surgery
AU - Fernandez Sanchez, David
AU - Garcia Sabido, Daniel
AU - Jovin, Tudor G.
AU - Villanova, Helena
AU - Andersson, Tommy
AU - Nogueira, Raul G.
AU - Cognard, Cristophe
AU - Ribo, M.
AU - Siddiqui, Adnan H.
AU - Galve, Iñaki
AU - Arad, Ofir
AU - Salmon, François
PY - 2021
DA - 2021/01/29
PB - BMJ
SP - 1157-1161
IS - 12
VL - 13
PMID - 33514612
SN - 1759-8478
SN - 1759-8486
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2021_Fernandez Sanchez,
author = {David Fernandez Sanchez and Daniel Garcia Sabido and Tudor G. Jovin and Helena Villanova and Tommy Andersson and Raul G. Nogueira and Cristophe Cognard and M. Ribo and Adnan H. Siddiqui and Iñaki Galve and Ofir Arad and François Salmon},
title = {Suction force rather than aspiration flow correlates with recanalization in hard clots: an in vitro study model},
journal = {Journal of NeuroInterventional Surgery},
year = {2021},
volume = {13},
publisher = {BMJ},
month = {jan},
url = {https://doi.org/10.1136/neurintsurg-2020-017242},
number = {12},
pages = {1157--1161},
doi = {10.1136/neurintsurg-2020-017242}
}
MLA
Cite this
MLA Copy
Fernandez Sanchez, David, et al. “Suction force rather than aspiration flow correlates with recanalization in hard clots: an in vitro study model.” Journal of NeuroInterventional Surgery, vol. 13, no. 12, Jan. 2021, pp. 1157-1161. https://doi.org/10.1136/neurintsurg-2020-017242.
Profiles