Genome, volume 68, pages 1-11

The typical and the atypical filamins of Drosophila

Tiara Mulder 1, 2
Jennifer Johnson 1, 2
Nicanor GONZALEZ Morales 1
Nicanor González-Morales 2
Publication typeJournal Article
Publication date2025-01-01
Journal: Genome
scimago Q2
SJR0.591
CiteScore5.3
Impact factor2.3
ISSN08312796, 14803321
Abstract

The actin cytoskeleton is a dynamic mesh of filaments that provide structural support for cells and respond to external deformation forces. Active sensing of these forces is crucial for the function of the actin cytoskeleton, and some actin crosslinkers accomplish it. One such crosslinker is filamin, a highly conserved actin crosslinker dimeric protein with an elastic region capable of responding to mechanical changes in the actin cytoskeleton. Filamins are required across various cells and tissues. In Drosophila early and recent studies have provided many details about filamin functions. This review centers on the two Drosophila filamins encoded by the cheerio and jitterbu g genes. We examine the structural and evolutionary aspects of filamin genes in flies, contrasting them with those of other model organisms. Then, we synthesize phenotypic data across diverse cell types. Additionally, we outline the genetic tools available for both genes. We also propose to divide filamins into typical and atypical based on the number of actin-binding domains and their relationship with other filamins.

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