Advancing Biophysics Using DNA Origami
DNA origami enables the bottom-up construction of chemically addressable, nanoscale objects with user-defined shapes and tailored functionalities. As such, not only can DNA origami objects be used to improve existing experimental methods in biophysics, but they also open up completely new avenues of exploration. In this review, we discuss basic biophysical concepts that are relevant for prospective DNA origami users. We summarize biochemical strategies for interfacing DNA origami with biomolecules of interest. We describe various applications of DNA origami, emphasizing the added value or new biophysical insights that can be generated: rulers and positioning devices, force measurement and force application devices, alignment supports for structural analysis for biomolecules in cryogenic electron microscopy and nuclear magnetic resonance, probes for manipulating and interacting with lipid membranes, and programmable nanopores. We conclude with some thoughts on so-far little explored opportunities for using DNA origami in more complex environments such as the cell or even organisms.
Top-30
Journals
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Nano Letters
2 publications, 3.85%
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ACS Nano
2 publications, 3.85%
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Bioconjugate Chemistry
2 publications, 3.85%
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Nanoscale
2 publications, 3.85%
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Science advances
2 publications, 3.85%
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American Journal of Physics
1 publication, 1.92%
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Nature Communications
1 publication, 1.92%
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Molecules
1 publication, 1.92%
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Applied Sciences (Switzerland)
1 publication, 1.92%
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Nature Physics
1 publication, 1.92%
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Computational and Structural Biotechnology Journal
1 publication, 1.92%
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Analytical Chemistry
1 publication, 1.92%
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NPG Asia Materials
1 publication, 1.92%
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Matter
1 publication, 1.92%
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Chemical Science
1 publication, 1.92%
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ChemBioChem
1 publication, 1.92%
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IEEE Open Journal of Nanotechnology
1 publication, 1.92%
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Methods in Molecular Biology
1 publication, 1.92%
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Small
1 publication, 1.92%
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Natural Computing Series
1 publication, 1.92%
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Applied Physics Reviews
1 publication, 1.92%
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bioRxiv
1 publication, 1.92%
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Biosensors and Bioelectronics
1 publication, 1.92%
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Small Structures
1 publication, 1.92%
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GEN Biotechnology
1 publication, 1.92%
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Journal of Physical Chemistry A
1 publication, 1.92%
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Advanced Materials Interfaces
1 publication, 1.92%
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Nano Trends
1 publication, 1.92%
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ChemPhysChem
1 publication, 1.92%
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Publishers
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American Chemical Society (ACS)
10 publications, 19.23%
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Wiley
9 publications, 17.31%
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Cold Spring Harbor Laboratory
8 publications, 15.38%
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Springer Nature
5 publications, 9.62%
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Elsevier
5 publications, 9.62%
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Royal Society of Chemistry (RSC)
4 publications, 7.69%
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MDPI
2 publications, 3.85%
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American Association for the Advancement of Science (AAAS)
2 publications, 3.85%
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American Association of Physics Teachers (AAPT)
1 publication, 1.92%
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Institute of Electrical and Electronics Engineers (IEEE)
1 publication, 1.92%
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AIP Publishing
1 publication, 1.92%
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Mary Ann Liebert
1 publication, 1.92%
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Science in China Press
1 publication, 1.92%
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The Royal Society
1 publication, 1.92%
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- We do not take into account publications without a DOI.
- Statistics recalculated weekly.