volume 23 issue 1 pages 153-172

Genome-Wide Analysis of Human Long Noncoding RNAs: A Provocative Review

Publication typeJournal Article
Publication date2022-08-31
scimago Q1
wos Q1
SJR4.280
CiteScore13.9
Impact factor7.9
ISSN15278204, 1545293X
Molecular Biology
Genetics
Genetics (clinical)
Abstract

Do long noncoding RNAs (lncRNAs) contribute little or substantively to human biology? To address how lncRNA loci and their transcripts, structures, interactions, and functions contribute to human traits and disease, we adopt a genome-wide perspective. We intend to provoke alternative interpretation of questionable evidence and thorough inquiry into unsubstantiated claims. We discuss pitfalls of lncRNA experimental and computational methods as well as opposing interpretations of their results. The majority of evidence, we argue, indicates that most lncRNA transcript models reflect transcriptional noise or provide minor regulatory roles, leaving relatively few human lncRNAs that contribute centrally to human development, physiology, or behavior. These important few tend to be spliced and better conserved but lack a simple syntax relating sequence to structure and mechanism, and so resist simple categorization. This genome-wide view should help investigators prioritize individual lncRNAs based on their likely contribution to human biology.

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GOST Copy
Ponting C. P., Haerty W. Genome-Wide Analysis of Human Long Noncoding RNAs: A Provocative Review // Annual Review of Genomics and Human Genetics. 2022. Vol. 23. No. 1. pp. 153-172.
GOST all authors (up to 50) Copy
Ponting C. P., Haerty W. Genome-Wide Analysis of Human Long Noncoding RNAs: A Provocative Review // Annual Review of Genomics and Human Genetics. 2022. Vol. 23. No. 1. pp. 153-172.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1146/annurev-genom-112921-123710
UR - https://doi.org/10.1146/annurev-genom-112921-123710
TI - Genome-Wide Analysis of Human Long Noncoding RNAs: A Provocative Review
T2 - Annual Review of Genomics and Human Genetics
AU - Ponting, Chris P.
AU - Haerty, Wilfried
PY - 2022
DA - 2022/08/31
PB - Annual Reviews
SP - 153-172
IS - 1
VL - 23
PMID - 35395170
SN - 1527-8204
SN - 1545-293X
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2022_Ponting,
author = {Chris P. Ponting and Wilfried Haerty},
title = {Genome-Wide Analysis of Human Long Noncoding RNAs: A Provocative Review},
journal = {Annual Review of Genomics and Human Genetics},
year = {2022},
volume = {23},
publisher = {Annual Reviews},
month = {aug},
url = {https://doi.org/10.1146/annurev-genom-112921-123710},
number = {1},
pages = {153--172},
doi = {10.1146/annurev-genom-112921-123710}
}
MLA
Cite this
MLA Copy
Ponting, Chris P., and Wilfried Haerty. “Genome-Wide Analysis of Human Long Noncoding RNAs: A Provocative Review.” Annual Review of Genomics and Human Genetics, vol. 23, no. 1, Aug. 2022, pp. 153-172. https://doi.org/10.1146/annurev-genom-112921-123710.