Genome-Wide Analysis of Human Long Noncoding RNAs: A Provocative Review
Do long noncoding RNAs (lncRNAs) contribute little or substantively to human biology? To address how lncRNA loci and their transcripts, structures, interactions, and functions contribute to human traits and disease, we adopt a genome-wide perspective. We intend to provoke alternative interpretation of questionable evidence and thorough inquiry into unsubstantiated claims. We discuss pitfalls of lncRNA experimental and computational methods as well as opposing interpretations of their results. The majority of evidence, we argue, indicates that most lncRNA transcript models reflect transcriptional noise or provide minor regulatory roles, leaving relatively few human lncRNAs that contribute centrally to human development, physiology, or behavior. These important few tend to be spliced and better conserved but lack a simple syntax relating sequence to structure and mechanism, and so resist simple categorization. This genome-wide view should help investigators prioritize individual lncRNAs based on their likely contribution to human biology.
Top-30
Journals
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International Journal of Molecular Sciences
3 publications, 3.3%
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eLife
3 publications, 3.3%
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Nature Communications
3 publications, 3.3%
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Cancers
2 publications, 2.2%
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Trends in Genetics
2 publications, 2.2%
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Cell
2 publications, 2.2%
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Plant Physiology
2 publications, 2.2%
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Nucleic Acids Research
2 publications, 2.2%
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RNA Biology
2 publications, 2.2%
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Biogerontology
2 publications, 2.2%
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Journal of Translational Genetics and Genomics
2 publications, 2.2%
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Journal of Clinical Medicine
1 publication, 1.1%
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Nature Methods
1 publication, 1.1%
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Cellular Signalling
1 publication, 1.1%
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Current Opinion in Cardiology
1 publication, 1.1%
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Advanced Genetics
1 publication, 1.1%
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Journal of Biomolecular Structure and Dynamics
1 publication, 1.1%
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Nature Reviews Cardiology
1 publication, 1.1%
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BMC Biology
1 publication, 1.1%
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Frontiers in RNA Research
1 publication, 1.1%
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Annual Review of Genomics and Human Genetics
1 publication, 1.1%
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Pathophysiology
1 publication, 1.1%
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American Journal of Human Genetics
1 publication, 1.1%
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Cell Systems
1 publication, 1.1%
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Genome Biology
1 publication, 1.1%
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Molecular Neurobiology
1 publication, 1.1%
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Wiley interdisciplinary reviews. RNA
1 publication, 1.1%
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Life Sciences
1 publication, 1.1%
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Nature Reviews Genetics
1 publication, 1.1%
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Publishers
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5
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15
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25
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Springer Nature
21 publications, 23.08%
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Cold Spring Harbor Laboratory
19 publications, 20.88%
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Elsevier
9 publications, 9.89%
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MDPI
8 publications, 8.79%
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Oxford University Press
7 publications, 7.69%
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Taylor & Francis
5 publications, 5.49%
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Wiley
3 publications, 3.3%
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eLife Sciences Publications
3 publications, 3.3%
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Frontiers Media S.A.
3 publications, 3.3%
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OAE Publishing Inc.
2 publications, 2.2%
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Ovid Technologies (Wolters Kluwer Health)
1 publication, 1.1%
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Annual Reviews
1 publication, 1.1%
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Pleiades Publishing
1 publication, 1.1%
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Bentham Science Publishers Ltd.
1 publication, 1.1%
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Proceedings of the National Academy of Sciences (PNAS)
1 publication, 1.1%
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SAGE
1 publication, 1.1%
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CAIRN
1 publication, 1.1%
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American Chemical Society (ACS)
1 publication, 1.1%
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Rockefeller University Press
1 publication, 1.1%
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Public Library of Science (PLoS)
1 publication, 1.1%
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- We do not take into account publications without a DOI.
- Statistics recalculated weekly.