Neural Tube Defects
Publication type: Journal Article
Publication date: 2014-07-08
scimago Q1
wos Q1
SJR: 7.112
CiteScore: 24.8
Impact factor: 13.2
ISSN: 0147006X, 15454126
PubMed ID:
25032496
General Neuroscience
Abstract
Neural tube defects (NTDs), including spina bifida and anencephaly, are severe birth defects of the central nervous system that originate during embryonic development when the neural tube fails to close completely. Human NTDs are multifactorial, with contributions from both genetic and environmental factors. The genetic basis is not yet well understood, but several nongenetic risk factors have been identified as have possibilities for prevention by maternal folic acid supplementation. Mechanisms underlying neural tube closure and NTDs may be informed by experimental models, which have revealed numerous genes whose abnormal function causes NTDs and have provided details of critical cellular and morphological events whose regulation is essential for closure. Such models also provide an opportunity to investigate potential risk factors and to develop novel preventive therapies.
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Metrics
514
Total citations:
514
Citations from 2024:
100
(19.53%)
Cite this
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MLA
Cite this
RIS
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TY - JOUR
DO - 10.1146/annurev-neuro-062012-170354
UR - https://doi.org/10.1146/annurev-neuro-062012-170354
TI - Neural Tube Defects
T2 - Annual Review of Neuroscience
AU - Greene, Nicholas D. E.
AU - Copp, Andrew J.
PY - 2014
DA - 2014/07/08
PB - Annual Reviews
SP - 221-242
IS - 1
VL - 37
PMID - 25032496
SN - 0147-006X
SN - 1545-4126
ER -
Cite this
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@article{2014_Greene,
author = {Nicholas D. E. Greene and Andrew J. Copp},
title = {Neural Tube Defects},
journal = {Annual Review of Neuroscience},
year = {2014},
volume = {37},
publisher = {Annual Reviews},
month = {jul},
url = {https://doi.org/10.1146/annurev-neuro-062012-170354},
number = {1},
pages = {221--242},
doi = {10.1146/annurev-neuro-062012-170354}
}
Cite this
MLA
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Greene, Nicholas D. E., and Andrew J. Copp. “Neural Tube Defects.” Annual Review of Neuroscience, vol. 37, no. 1, Jul. 2014, pp. 221-242. https://doi.org/10.1146/annurev-neuro-062012-170354.