Annual Review of Biochemistry, volume 82, issue 1, pages 775-797
Nanobodies: Natural Single-Domain Antibodies
Publication type: Journal Article
Publication date: 2013-06-02
Journal:
Annual Review of Biochemistry
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 16.6
ISSN: 00664154, 15454509
Biochemistry
Abstract
Sera of camelids contain both conventional heterotetrameric antibodies and unique functional heavy (H)-chain antibodies (HCAbs). The H chain of these homodimeric antibodies consists of one antigen-binding domain, the VHH, and two constant domains. HCAbs fail to incorporate light (L) chains owing to the deletion of the first constant domain and a reshaped surface at the VHH side, which normally associates with L chains in conventional antibodies. The genetic elements composing HCAbs have been identified, but the in vivo generation of these antibodies from their dedicated genes into antigen-specific and affinity-matured bona fide antibodies remains largely underinvestigated. However, the facile identification of antigen-specific VHHs and their beneficial biochemical and economic properties (size, affinity, specificity, stability, production cost) supported by multiple crystal structures have encouraged antibody engineering of these single-domain antibodies for use as a research tool and in biotechnology and medicine.
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Muyldermans S. Nanobodies: Natural Single-Domain Antibodies // Annual Review of Biochemistry. 2013. Vol. 82. No. 1. pp. 775-797.
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Muyldermans S. Nanobodies: Natural Single-Domain Antibodies // Annual Review of Biochemistry. 2013. Vol. 82. No. 1. pp. 775-797.
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TY - JOUR
DO - 10.1146/annurev-biochem-063011-092449
UR - https://doi.org/10.1146/annurev-biochem-063011-092449
TI - Nanobodies: Natural Single-Domain Antibodies
T2 - Annual Review of Biochemistry
AU - Muyldermans, Serge
PY - 2013
DA - 2013/06/02 00:00:00
PB - Annual Reviews
SP - 775-797
IS - 1
VL - 82
SN - 0066-4154
SN - 1545-4509
ER -
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@article{2013_Muyldermans,
author = {Serge Muyldermans},
title = {Nanobodies: Natural Single-Domain Antibodies},
journal = {Annual Review of Biochemistry},
year = {2013},
volume = {82},
publisher = {Annual Reviews},
month = {jun},
url = {https://doi.org/10.1146/annurev-biochem-063011-092449},
number = {1},
pages = {775--797},
doi = {10.1146/annurev-biochem-063011-092449}
}
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Muyldermans, Serge. “Nanobodies: Natural Single-Domain Antibodies.” Annual Review of Biochemistry, vol. 82, no. 1, Jun. 2013, pp. 775-797. https://doi.org/10.1146/annurev-biochem-063011-092449.