Impact of Soluble Epoxide Hydrolase and Epoxyeicosanoids on Human Health
Тип публикации: Journal Article
Дата публикации: 2013-01-06
scimago Q1
wos Q1
БС1
SJR: 4.029
CiteScore: 27.4
Impact factor: 13.1
ISSN: 03621642, 15454304
PubMed ID:
23020295
Pharmacology
Toxicology
Краткое описание
The presence of epoxyeicosatrienoic acids (EETs) in tissues and their metabolism by soluble epoxide hydrolase (sEH) to 1,2-diols were first reported 30 years ago. However, appreciation of their importance in cell biology and physiology has greatly accelerated over the past decade with the discovery of metabolically stable inhibitors of sEH, the commercial availability of EETs, and the development of analytical methods for the quantification of EETs and their diols. Numerous roles of EETs in regulatory biology now are clear, and the value of sEH inhibition in various animal models of disease has been demonstrated. Here, we review these results and discuss how the pharmacological stabilization of EETs and other natural epoxy-fatty acids could lead to possible disease therapies.
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Morisseau C., Hammock B. D. Impact of Soluble Epoxide Hydrolase and Epoxyeicosanoids on Human Health // Annual Review of Pharmacology and Toxicology. 2013. Vol. 53. No. 1. pp. 37-58.
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Morisseau C., Hammock B. D. Impact of Soluble Epoxide Hydrolase and Epoxyeicosanoids on Human Health // Annual Review of Pharmacology and Toxicology. 2013. Vol. 53. No. 1. pp. 37-58.
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TY - JOUR
DO - 10.1146/annurev-pharmtox-011112-140244
UR - https://doi.org/10.1146/annurev-pharmtox-011112-140244
TI - Impact of Soluble Epoxide Hydrolase and Epoxyeicosanoids on Human Health
T2 - Annual Review of Pharmacology and Toxicology
AU - Morisseau, Christophe
AU - Hammock, Bruce D.
PY - 2013
DA - 2013/01/06
PB - Annual Reviews
SP - 37-58
IS - 1
VL - 53
PMID - 23020295
SN - 0362-1642
SN - 1545-4304
ER -
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@article{2013_Morisseau,
author = {Christophe Morisseau and Bruce D. Hammock},
title = {Impact of Soluble Epoxide Hydrolase and Epoxyeicosanoids on Human Health},
journal = {Annual Review of Pharmacology and Toxicology},
year = {2013},
volume = {53},
publisher = {Annual Reviews},
month = {jan},
url = {https://doi.org/10.1146/annurev-pharmtox-011112-140244},
number = {1},
pages = {37--58},
doi = {10.1146/annurev-pharmtox-011112-140244}
}
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MLA
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Morisseau, Christophe, and Bruce D. Hammock. “Impact of Soluble Epoxide Hydrolase and Epoxyeicosanoids on Human Health.” Annual Review of Pharmacology and Toxicology, vol. 53, no. 1, Jan. 2013, pp. 37-58. https://doi.org/10.1146/annurev-pharmtox-011112-140244.