Annual Review of Biochemistry, volume 77, issue 1, pages 229-257
Mechanism of Eukaryotic Homologous Recombination
2
Department of Biochemistry and Kaplan Comprehensive Cancer Institute, New York University School of Medicine, New York, New York 10016;
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Publication type: Journal Article
Publication date: 2008-06-01
Journal:
Annual Review of Biochemistry
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 16.6
ISSN: 00664154, 15454509
Biochemistry
Abstract
Homologous recombination (HR) serves to eliminate deleterious lesions, such as double-stranded breaks and interstrand crosslinks, from chromosomes. HR is also critical for the preservation of replication forks, for telomere maintenance, and chromosome segregation in meiosis I. As such, HR is indispensable for the maintenance of genome integrity and the avoidance of cancers in humans. The HR reaction is mediated by a conserved class of enzymes termed recombinases. Two recombinases, Rad51 and Dmc1, catalyze the pairing and shuffling of homologous DNA sequences in eukaryotic cells via a filamentous intermediate on ssDNA called the presynaptic filament. The assembly of the presynaptic filament is a rate-limiting process that is enhanced by recombination mediators, such as the breast tumor suppressor BRCA2. HR accessory factors that facilitate other stages of the Rad51- and Dmc1-catalyzed homologous DNA pairing and strand exchange reaction have also been identified. Recent progress on elucidating the mechanisms of action of Rad51 and Dmc1 and their cohorts of ancillary factors is reviewed here.
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San Filippo J., Sung P., Klein H. Mechanism of Eukaryotic Homologous Recombination // Annual Review of Biochemistry. 2008. Vol. 77. No. 1. pp. 229-257.
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San Filippo J., Sung P., Klein H. Mechanism of Eukaryotic Homologous Recombination // Annual Review of Biochemistry. 2008. Vol. 77. No. 1. pp. 229-257.
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TY - JOUR
DO - 10.1146/annurev.biochem.77.061306.125255
UR - https://doi.org/10.1146%2Fannurev.biochem.77.061306.125255
TI - Mechanism of Eukaryotic Homologous Recombination
T2 - Annual Review of Biochemistry
AU - San Filippo, Joseph
AU - Sung, Patrick
AU - Klein, Hannah
PY - 2008
DA - 2008/06/01 00:00:00
PB - Annual Reviews
SP - 229-257
IS - 1
VL - 77
SN - 0066-4154
SN - 1545-4509
ER -
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@article{2008_San Filippo,
author = {Joseph San Filippo and Patrick Sung and Hannah Klein},
title = {Mechanism of Eukaryotic Homologous Recombination},
journal = {Annual Review of Biochemistry},
year = {2008},
volume = {77},
publisher = {Annual Reviews},
month = {jun},
url = {https://doi.org/10.1146%2Fannurev.biochem.77.061306.125255},
number = {1},
pages = {229--257},
doi = {10.1146/annurev.biochem.77.061306.125255}
}
Cite this
MLA
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San Filippo, Joseph, et al. “Mechanism of Eukaryotic Homologous Recombination.” Annual Review of Biochemistry, vol. 77, no. 1, Jun. 2008, pp. 229-257. https://doi.org/10.1146%2Fannurev.biochem.77.061306.125255.