Tumor Cell Death Induced by Topoisomerase-Targeting Drugs
1
Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854;,,
|
Publication type: Journal Article
Publication date: 2001-04-11
scimago Q1
wos Q1
SJR: 4.029
CiteScore: 27.4
Impact factor: 13.1
ISSN: 03621642, 15454304
PubMed ID:
11264450
Pharmacology
Toxicology
Abstract
DNA topoisomerases are double-edged swords. They are essential for many vital functions of DNA during normal cell growth. However, they are also highly vulnerable under various physiological and nonphysiological stresses because of their delicate act on breaking and rejoining DNA. These stresses (e.g. exposure to topoisomerase poisons, acidic pH, and oxidative stresses) can convert DNA topoisomerases into DNA-breaking nucleases, resulting in cell death and/or genomic instability. The importance of topoisomerase-mediated DNA cleavage in tumor cell death and carcinogenesis has been recognized. This review focuses on recent findings concerning the molecular mechanisms of the stress responses to topoisomerase-mediated DNA damage. The involvement of ubiquitin/26S proteasome and SUMO/UBC9 in these processes, as well as the role of topoisomerase cleavable complexes in apoptotic cell death are discussed.
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Metrics
417
Total citations:
417
Citations from 2024:
17
(4.08%)
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GOST
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Li T., Liu L. F. Tumor Cell Death Induced by Topoisomerase-Targeting Drugs // Annual Review of Pharmacology and Toxicology. 2001. Vol. 41. No. 1. pp. 53-77.
GOST all authors (up to 50)
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Li T., Liu L. F. Tumor Cell Death Induced by Topoisomerase-Targeting Drugs // Annual Review of Pharmacology and Toxicology. 2001. Vol. 41. No. 1. pp. 53-77.
Cite this
RIS
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TY - JOUR
DO - 10.1146/annurev.pharmtox.41.1.53
UR - https://doi.org/10.1146/annurev.pharmtox.41.1.53
TI - Tumor Cell Death Induced by Topoisomerase-Targeting Drugs
T2 - Annual Review of Pharmacology and Toxicology
AU - Li, Tsai-Kun
AU - Liu, Leroy F.
PY - 2001
DA - 2001/04/11
PB - Annual Reviews
SP - 53-77
IS - 1
VL - 41
PMID - 11264450
SN - 0362-1642
SN - 1545-4304
ER -
Cite this
BibTex (up to 50 authors)
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@article{2001_Li,
author = {Tsai-Kun Li and Leroy F. Liu},
title = {Tumor Cell Death Induced by Topoisomerase-Targeting Drugs},
journal = {Annual Review of Pharmacology and Toxicology},
year = {2001},
volume = {41},
publisher = {Annual Reviews},
month = {apr},
url = {https://doi.org/10.1146/annurev.pharmtox.41.1.53},
number = {1},
pages = {53--77},
doi = {10.1146/annurev.pharmtox.41.1.53}
}
Cite this
MLA
Copy
Li, Tsai-Kun, and Leroy F. Liu. “Tumor Cell Death Induced by Topoisomerase-Targeting Drugs.” Annual Review of Pharmacology and Toxicology, vol. 41, no. 1, Apr. 2001, pp. 53-77. https://doi.org/10.1146/annurev.pharmtox.41.1.53.