Physiology, volume 39, issue 6, pages 401-411
Liver transplantation: a test of cellular physiology, preservation and injury
Brunna Martins
1
,
B. Martins
1
,
Jan Mossemann
1
,
J Mossemann
1
,
Fiorelle Aguilar
1
,
F. AGUILAR
1
,
Sarah Zhao
1
,
S. Zhao
2
,
Philip J Bilan
1
,
Blayne Amir Sayed
1
,
Blayne Sayed
1, 3, 4
4
Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada
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Publication type: Journal Article
Publication date: 2024-11-01
Journal:
Physiology
scimago Q1
SJR: 2.051
CiteScore: 14.5
Impact factor: 5.3
ISSN: 15489213, 15489221, 26318261
Abstract
Liver transplantation has evolved into a mature clinical field, but scarcity of usable organs poses a unique challenge. Expanding the donor pool requires novel approaches for protecting hepatic physiology and cellular homeostasis. Here we define hepatocellular injury during transplantation, with an emphasis on modifiable cell death pathways as future therapeutics.
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