Open Access
Spontaneous Remission in an Older Patient with RelapsedFLT3ITD Mutant AML
Pankit Vachhani
1
,
Jason H Mendler
2
,
Andrew Evans
3
,
George Deeb
4
,
Petr Starostik
5
,
Paul K. Wallace
6
,
Eunice S. Wang
1
1
Leukemia Service, Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA
|
6
Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA
|
Publication type: Journal Article
Publication date: 2016-11-10
wos Q4
SJR: —
CiteScore: —
Impact factor: 0.7
ISSN: 20906560, 20906579
PubMed ID:
28127477
Cell Biology
Developmental Biology
Anatomy
Embryology
Abstract
Spontaneous remission (SR) of acute myeloid leukemia (AML) is a very rare phenomenon. AML characterized byFLT3internal tandem duplication (FLT3ITD) is typically associated with an aggressive clinical course with rapid progression, relapse, and short overall survival in the absence of transplantation. We report here the first case of SR ofFLT3ITD mutant AML in the literature. Our patient was an elderly woman with relapsedNPM1andFLT3ITD mutant AML whose disease underwent SR for a brief duration without precipitating cause. We review the potential immune mechanisms underlying SR in AML and discuss the implications for novel immunotherapeutic approaches forFLT3mutant AML.
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Metrics
8
Total citations:
8
Citations from 2024:
2
(25%)
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RIS |
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GOST
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Vachhani P. et al. Spontaneous Remission in an Older Patient with RelapsedFLT3ITD Mutant AML // Case Reports in Hematology. 2016. Vol. 2016. pp. 1-7.
GOST all authors (up to 50)
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Vachhani P., Mendler J. H., Evans A., Deeb G., Starostik P., Wallace P. K., Wang E. S. Spontaneous Remission in an Older Patient with RelapsedFLT3ITD Mutant AML // Case Reports in Hematology. 2016. Vol. 2016. pp. 1-7.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1155/2016/1259759
UR - https://doi.org/10.1155/2016/1259759
TI - Spontaneous Remission in an Older Patient with RelapsedFLT3ITD Mutant AML
T2 - Case Reports in Hematology
AU - Vachhani, Pankit
AU - Mendler, Jason H
AU - Evans, Andrew
AU - Deeb, George
AU - Starostik, Petr
AU - Wallace, Paul K.
AU - Wang, Eunice S.
PY - 2016
DA - 2016/11/10
PB - Hindawi Limited
SP - 1-7
VL - 2016
PMID - 28127477
SN - 2090-6560
SN - 2090-6579
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2016_Vachhani,
author = {Pankit Vachhani and Jason H Mendler and Andrew Evans and George Deeb and Petr Starostik and Paul K. Wallace and Eunice S. Wang},
title = {Spontaneous Remission in an Older Patient with RelapsedFLT3ITD Mutant AML},
journal = {Case Reports in Hematology},
year = {2016},
volume = {2016},
publisher = {Hindawi Limited},
month = {nov},
url = {https://doi.org/10.1155/2016/1259759},
pages = {1--7},
doi = {10.1155/2016/1259759}
}