Open Access
Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin
Yulia N Nosova
1
,
Ilia V Zenin
1
,
Varvara P Maximova
2
,
Kirill I Kirsanov
2
,
Anna A Lobas
3
,
Olga N Kovaleva
4
,
Elena R. Milaeva
1
,
Markus Galanski
5
,
Bernhard K. Keppler
5
,
Publication type: Journal Article
Publication date: 2017-07-19
scimago Q1
wos Q1
SJR: 0.871
CiteScore: 12.8
Impact factor: 4.1
ISSN: 15653633, 1687479X
PubMed ID:
28804273
Organic Chemistry
Biochemistry
Inorganic Chemistry
Abstract
We present the synthesis and cytotoxic potencies of new Pt(IV) complexes with bexarotene, an anticancer drug that induces cell differentiation and apoptosis via selective activation of retinoid X receptors. In these complexes bexarotene is positioned as an axial ligand. The complex of one bexarotene ligand attached to Pt(IV) oxaliplatin moiety was potent whereas its counterpart carrying two bexarotene ligands was inactive.
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Metrics
8
Total citations:
8
Citations from 2025:
2
(25%)
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GOST
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Nosova Y. N. et al. Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin // Bioinorganic Chemistry and Applications. 2017. Vol. 2017. pp. 1-6.
GOST all authors (up to 50)
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Nosova Y. N., Zenin I. V., Maximova V. P., Zhidkova E. M., Kirsanov K. I., Lesovaya E. A., Lobas A. A., Gorshkov M. V., Kovaleva O. N., R. Milaeva E., Galanski M., Keppler B. K., Nazarov A. A. Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin // Bioinorganic Chemistry and Applications. 2017. Vol. 2017. pp. 1-6.
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RIS
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TY - JOUR
DO - 10.1155/2017/4736321
UR - https://doi.org/10.1155/2017/4736321
TI - Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin
T2 - Bioinorganic Chemistry and Applications
AU - Nosova, Yulia N
AU - Zenin, Ilia V
AU - Maximova, Varvara P
AU - Zhidkova, Ekaterina M
AU - Kirsanov, Kirill I
AU - Lesovaya, Ekaterina A
AU - Lobas, Anna A
AU - Gorshkov, Mikhail V
AU - Kovaleva, Olga N
AU - R. Milaeva, Elena
AU - Galanski, Markus
AU - Keppler, Bernhard K.
AU - Nazarov, Alexey A.
PY - 2017
DA - 2017/07/19
PB - Hindawi Limited
SP - 1-6
VL - 2017
PMID - 28804273
SN - 1565-3633
SN - 1687-479X
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2017_Nosova,
author = {Yulia N Nosova and Ilia V Zenin and Varvara P Maximova and Ekaterina M Zhidkova and Kirill I Kirsanov and Ekaterina A Lesovaya and Anna A Lobas and Mikhail V Gorshkov and Olga N Kovaleva and Elena R. Milaeva and Markus Galanski and Bernhard K. Keppler and Alexey A. Nazarov},
title = {Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin},
journal = {Bioinorganic Chemistry and Applications},
year = {2017},
volume = {2017},
publisher = {Hindawi Limited},
month = {jul},
url = {https://doi.org/10.1155/2017/4736321},
pages = {1--6},
doi = {10.1155/2017/4736321}
}