Open Access
Neural Plasticity, volume 2020, pages 1-13
Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities
1
Department of Neurology, Beijing Haidian Hospital, Beijing, China
|
3
Department of Biology, Boston University, Boston, MA, USA
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Publication type: Journal Article
Publication date: 2020-01-27
Journal:
Neural Plasticity
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor: 3.1
ISSN: 20905904, 16875443
PubMed ID:
32399020
Neurology
Neurology (clinical)
Abstract
With the rise in the aging global population, stroke comorbidities have become a serious health threat and a tremendous economic burden on human society. Current therapeutic strategies mainly focus on protecting neurons from cytotoxic damage at the acute phase upon stroke onset, which not only is a difficult way to ameliorate stroke symptoms but also presents a challenge for the patients to receive effective treatment in time. The brain-derived neurotrophic factor (BDNF) is the most abundant neurotrophin in the adult brain, which possesses a remarkable capability to repair brain damage. Recent promising preclinical outcomes have made BDNF a popular late-stage target in the development of novel stroke treatments. In this review, we aim to summarize the latest progress in the understanding of the cellular/molecular mechanisms underlying stroke pathogenesis, current strategies and difficulties in drug development, the mechanism of BDNF action in poststroke neurorehabilitation and neuroplasticity, and recent updates in novel therapeutic methods.
Citations by journals
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4
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Neural Regeneration Research
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Neural Regeneration Research
4 publications, 6.35%
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Stroke
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Stroke
3 publications, 4.76%
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Journal of Chemical Neuroanatomy
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Journal of Chemical Neuroanatomy
3 publications, 4.76%
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F1000Research
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F1000Research
2 publications, 3.17%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
2 publications, 3.17%
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Frontiers in Pharmacology
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Frontiers in Pharmacology
2 publications, 3.17%
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Frontiers in Cellular Neuroscience
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Frontiers in Cellular Neuroscience
2 publications, 3.17%
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Biomedicines
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Biomedicines
1 publication, 1.59%
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Central Nervous System Agents in Medicinal Chemistry
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Central Nervous System Agents in Medicinal Chemistry
1 publication, 1.59%
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Genes
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Genes
1 publication, 1.59%
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Apoptosis : an international journal on programmed cell death
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Apoptosis : an international journal on programmed cell death
1 publication, 1.59%
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Journal of Clinical Medicine
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Journal of Clinical Medicine
1 publication, 1.59%
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Biomolecules
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Biomolecules
1 publication, 1.59%
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Neurology Research International
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Neurology Research International
1 publication, 1.59%
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Frontiers in Physiology
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Frontiers in Physiology
1 publication, 1.59%
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Frontiers in Aging Neuroscience
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Frontiers in Aging Neuroscience
1 publication, 1.59%
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Frontiers in Neuroscience
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Frontiers in Neuroscience
1 publication, 1.59%
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Biosensors
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Biosensors
1 publication, 1.59%
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Journal of Molecular Neuroscience
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Journal of Molecular Neuroscience
1 publication, 1.59%
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BMC Neurology
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BMC Neurology
1 publication, 1.59%
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Metabolic Brain Disease
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Metabolic Brain Disease
1 publication, 1.59%
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Chemical Engineering Journal
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Chemical Engineering Journal
1 publication, 1.59%
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Journal of Controlled Release
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Journal of Controlled Release
1 publication, 1.59%
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Autonomic Neuroscience: Basic and Clinical
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Autonomic Neuroscience: Basic and Clinical
1 publication, 1.59%
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Heliyon
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Heliyon
1 publication, 1.59%
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Biology
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Biology
1 publication, 1.59%
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Brain Hemorrhages
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Brain Hemorrhages
1 publication, 1.59%
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Neurochemistry International
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Neurochemistry International
1 publication, 1.59%
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Brain Research
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Brain Research
1 publication, 1.59%
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ACS Chemical Neuroscience
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ACS Chemical Neuroscience
1 publication, 1.59%
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1
2
3
4
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Citations by publishers
2
4
6
8
10
12
14
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Elsevier
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Elsevier
14 publications, 22.22%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
10 publications, 15.87%
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Springer Nature
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Springer Nature
9 publications, 14.29%
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Frontiers Media S.A.
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Frontiers Media S.A.
8 publications, 12.7%
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Wolters Kluwer Health
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Wolters Kluwer Health
7 publications, 11.11%
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Wiley
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Wiley
3 publications, 4.76%
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F1000 Research
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F1000 Research
2 publications, 3.17%
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Hindawi Limited
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Hindawi Limited
2 publications, 3.17%
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Bentham Science
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Bentham Science
1 publication, 1.59%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
1 publication, 1.59%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 1.59%
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Eco-Vector LLC
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Eco-Vector LLC
1 publication, 1.59%
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Hans Publishers
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Hans Publishers
1 publication, 1.59%
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Sovero Press Publishing House
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Sovero Press Publishing House, 1, 1.59%
Sovero Press Publishing House
1 publication, 1.59%
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Spandidos Publications
|
Spandidos Publications
1 publication, 1.59%
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2
4
6
8
10
12
14
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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GOST
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Liu W. et al. Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities // Neural Plasticity. 2020. Vol. 2020. pp. 1-13.
GOST all authors (up to 50)
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Liu W., Wang X., O'Connor M., Wang G., Han F. Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities // Neural Plasticity. 2020. Vol. 2020. pp. 1-13.
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TY - JOUR
DO - 10.1155/2020/1969482
UR - https://doi.org/10.1155%2F2020%2F1969482
TI - Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities
T2 - Neural Plasticity
AU - Wang, Xiaohui
AU - O'Connor, M.
AU - Wang, Guan
AU - Han, Fang
AU - Liu, Wei
PY - 2020
DA - 2020/01/27 00:00:00
PB - Hindawi Limited
SP - 1-13
VL - 2020
PMID - 32399020
SN - 2090-5904
SN - 1687-5443
ER -
Cite this
BibTex
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@article{2020_Liu
author = {Xiaohui Wang and M. O'Connor and Guan Wang and Fang Han and Wei Liu},
title = {Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities},
journal = {Neural Plasticity},
year = {2020},
volume = {2020},
publisher = {Hindawi Limited},
month = {jan},
url = {https://doi.org/10.1155%2F2020%2F1969482},
pages = {1--13},
doi = {10.1155/2020/1969482}
}