Open Access
Open access
Neural Plasticity, volume 2020, pages 1-13

Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities

Liu Wei 1
Wang Xiaohui 2
O'Connor M. 3
Wang Guan 3
1
 
Department of Neurology, Beijing Haidian Hospital, Beijing, China
3
 
Department of Biology, Boston University, Boston, MA, USA
Publication typeJournal Article
Publication date2020-01-27
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor3.1
ISSN20905904, 16875443
PubMed ID:  32399020
Neurology
Neurology (clinical)
Abstract
With the rise in the aging global population, stroke comorbidities have become a serious health threat and a tremendous economic burden on human society. Current therapeutic strategies mainly focus on protecting neurons from cytotoxic damage at the acute phase upon stroke onset, which not only is a difficult way to ameliorate stroke symptoms but also presents a challenge for the patients to receive effective treatment in time. The brain-derived neurotrophic factor (BDNF) is the most abundant neurotrophin in the adult brain, which possesses a remarkable capability to repair brain damage. Recent promising preclinical outcomes have made BDNF a popular late-stage target in the development of novel stroke treatments. In this review, we aim to summarize the latest progress in the understanding of the cellular/molecular mechanisms underlying stroke pathogenesis, current strategies and difficulties in drug development, the mechanism of BDNF action in poststroke neurorehabilitation and neuroplasticity, and recent updates in novel therapeutic methods.

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GOST Copy
Liu W. et al. Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities // Neural Plasticity. 2020. Vol. 2020. pp. 1-13.
GOST all authors (up to 50) Copy
Liu W., Wang X., O'Connor M., Wang G., Han F. Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities // Neural Plasticity. 2020. Vol. 2020. pp. 1-13.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1155/2020/1969482
UR - https://doi.org/10.1155%2F2020%2F1969482
TI - Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities
T2 - Neural Plasticity
AU - Wang, Xiaohui
AU - O'Connor, M.
AU - Wang, Guan
AU - Han, Fang
AU - Liu, Wei
PY - 2020
DA - 2020/01/27 00:00:00
PB - Hindawi Limited
SP - 1-13
VL - 2020
PMID - 32399020
SN - 2090-5904
SN - 1687-5443
ER -
BibTex
Cite this
BibTex Copy
@article{2020_Liu
author = {Xiaohui Wang and M. O'Connor and Guan Wang and Fang Han and Wei Liu},
title = {Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities},
journal = {Neural Plasticity},
year = {2020},
volume = {2020},
publisher = {Hindawi Limited},
month = {jan},
url = {https://doi.org/10.1155%2F2020%2F1969482},
pages = {1--13},
doi = {10.1155/2020/1969482}
}
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