Open Access
A Recent Overview of 1,2,3-Triazole-Containing Hybrids as Novel Antifungal Agents: Focusing on Synthesis, Mechanism of Action, and Structure-Activity Relationship (SAR)
Mahrokh Marzi
1
,
Mojtaba Farjam
1, 2
,
Zahra Kazeminejad
3
,
A Shiroudi
4
,
Seyed Amin Kouhpayeh
2
,
Publication type: Journal Article
Publication date: 2022-01-06
scimago Q2
wos Q2
SJR: 0.546
CiteScore: 6.8
Impact factor: 2.6
ISSN: 20909063, 20909071, 29577276
General Chemistry
Abstract
A pharmacophore system has been found as 1,2,3-triazole, a five-membered heterocycle ring with nitrogen heteroatoms. These heterocyclic compounds can be produced using azide-alkyne cycloaddition processes catalyzed by ruthenium or copper. The bioactive compounds demonstrated antitubercular, antibacterial, anti-inflammatory, anticancer, antioxidant, antiviral, and antidiabetic properties. This heterocycle molecule, in particular, with one or more 1,2,3-triazole cores has been found to have the most powerful antifungal effects. The goal of this review is to highlight recent developments in the synthesis and structure-activity relationship (SAR) investigation of this prospective fungicidal chemical. Also there have been explained drugs and mechanism of action of a triazole compound with antifungal activity. This review will be useful in a variety of fields, including medicinal chemistry, organic chemistry, mycology, and pharmacology.
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Metrics
51
Total citations:
51
Citations from 2024:
38
(74.51%)
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GOST
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Marzi M. et al. A Recent Overview of 1,2,3-Triazole-Containing Hybrids as Novel Antifungal Agents: Focusing on Synthesis, Mechanism of Action, and Structure-Activity Relationship (SAR) // Journal of Chemistry. 2022. Vol. 2022. pp. 1-50.
GOST all authors (up to 50)
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Marzi M., Farjam M., Kazeminejad Z., Shiroudi A., Kouhpayeh S. A., Zarenezhad E. A Recent Overview of 1,2,3-Triazole-Containing Hybrids as Novel Antifungal Agents: Focusing on Synthesis, Mechanism of Action, and Structure-Activity Relationship (SAR) // Journal of Chemistry. 2022. Vol. 2022. pp. 1-50.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1155/2022/7884316
UR - https://doi.org/10.1155/2022/7884316
TI - A Recent Overview of 1,2,3-Triazole-Containing Hybrids as Novel Antifungal Agents: Focusing on Synthesis, Mechanism of Action, and Structure-Activity Relationship (SAR)
T2 - Journal of Chemistry
AU - Marzi, Mahrokh
AU - Farjam, Mojtaba
AU - Kazeminejad, Zahra
AU - Shiroudi, A
AU - Kouhpayeh, Seyed Amin
AU - Zarenezhad, Elham
PY - 2022
DA - 2022/01/06
PB - Hindawi Limited
SP - 1-50
VL - 2022
SN - 2090-9063
SN - 2090-9071
SN - 2957-7276
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2022_Marzi,
author = {Mahrokh Marzi and Mojtaba Farjam and Zahra Kazeminejad and A Shiroudi and Seyed Amin Kouhpayeh and Elham Zarenezhad},
title = {A Recent Overview of 1,2,3-Triazole-Containing Hybrids as Novel Antifungal Agents: Focusing on Synthesis, Mechanism of Action, and Structure-Activity Relationship (SAR)},
journal = {Journal of Chemistry},
year = {2022},
volume = {2022},
publisher = {Hindawi Limited},
month = {jan},
url = {https://doi.org/10.1155/2022/7884316},
pages = {1--50},
doi = {10.1155/2022/7884316}
}