Smoking and Pancreatic Cancer Incidence: A Pooled Analysis of 10 Population-Based Cohort Studies in Japan
Background:
Detailed prospective evaluation of cigarette smoking associated with pancreatic cancer risk in large Asian populations is limited. The aim of this study was to examine this association in a Japanese population, with a particular focus on evaluating sex differences.
Methods:
We performed a pooled analysis of 10 population-based cohort studies. We calculated study-specific HRs and 95% confidence intervals (CI) using Cox proportional hazards regression, and then estimated summary HRs by pooling these estimates with a random effects model.
Results:
During 4,695,593 person-years of follow-up in 354,154 participants, 1,779 incident pancreatic cancer cases were identified. We observed an increased pancreatic cancer risk for current smoking compared with never smoking in both males [HR (95% CI), 1.59 (1.32–1.91)] and females [HR (95% CI), 1.81 (1.43–2.30)]. Significant risk elevations for former smoking and small cumulative dose of ≤20 pack-years (PY) were observed only among females, regardless of environmental tobacco smoke exposure. Trend analysis indicated significant 6% and nonsignificant 6% increases in pancreatic cancer risk for every 10 PYs in males and females, respectively. Risk became comparable with never smokers after 5 years of smoking cessation in males. In females, however, we observed no risk attenuation by smoking cessation.
Conclusions:
This study supports the well-known association between smoking and pancreatic cancer and indicates potential sex differences in a Japanese population. Quitting smoking would be beneficial for pancreatic cancer prevention, especially in males.
Impact:
Pancreatic cancer risk is increased with cumulative smoking exposure and decreased with smoking cessation, with potential sex differences.
Top-30
Journals
|
1
2
|
|
|
International Journal of Environmental Research and Public Health
2 publications, 6.67%
|
|
|
Cancer Causes and Control
2 publications, 6.67%
|
|
|
Medicina
1 publication, 3.33%
|
|
|
Nature Reviews Gastroenterology and Hepatology
1 publication, 3.33%
|
|
|
British Journal of Cancer
1 publication, 3.33%
|
|
|
Digestive Diseases and Sciences
1 publication, 3.33%
|
|
|
Digestive and Liver Disease
1 publication, 3.33%
|
|
|
International Journal of Cancer
1 publication, 3.33%
|
|
|
Cancer Medicine
1 publication, 3.33%
|
|
|
Journal of Clinical Medicine
1 publication, 3.33%
|
|
|
Annals of Global Health
1 publication, 3.33%
|
|
|
United European Gastroenterology Journal
1 publication, 3.33%
|
|
|
World Chinese Journal of Digestology
1 publication, 3.33%
|
|
|
Familial Cancer
1 publication, 3.33%
|
|
|
BMC Cancer
1 publication, 3.33%
|
|
|
Cancers
1 publication, 3.33%
|
|
|
Suizo
1 publication, 3.33%
|
|
|
Cancer Reports
1 publication, 3.33%
|
|
|
Annals of Medicine
1 publication, 3.33%
|
|
|
Scientific Reports
1 publication, 3.33%
|
|
|
ESMO Open
1 publication, 3.33%
|
|
|
Frontiers in Oncology
1 publication, 3.33%
|
|
|
Frontiers in Surgery
1 publication, 3.33%
|
|
|
Gut Medicine
1 publication, 3.33%
|
|
|
1
2
|
Publishers
|
1
2
3
4
5
6
7
8
9
|
|
|
Springer Nature
9 publications, 30%
|
|
|
MDPI
5 publications, 16.67%
|
|
|
Wiley
4 publications, 13.33%
|
|
|
Elsevier
2 publications, 6.67%
|
|
|
Frontiers Media S.A.
2 publications, 6.67%
|
|
|
Ubiquity Press
1 publication, 3.33%
|
|
|
Research Square Platform LLC
1 publication, 3.33%
|
|
|
SAGE
1 publication, 3.33%
|
|
|
Baishideng Publishing Group
1 publication, 3.33%
|
|
|
Japan Pancreas Society
1 publication, 3.33%
|
|
|
Taylor & Francis
1 publication, 3.33%
|
|
|
1
2
3
4
5
6
7
8
9
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.