AACR Project GENIE: Powering Precision Medicine through an International Consortium
Тип публикации: Journal Article
Дата публикации: 2017-08-01
scimago Q1
wos Q1
БС1
SJR: 7.283
CiteScore: 24.8
Impact factor: 33.3
ISSN: 21598274, 21598290
PubMed ID:
28572459
Oncology
Краткое описание
The AACR Project GENIE is an international data-sharing consortium focused on generating an evidence base for precision cancer medicine by integrating clinical-grade cancer genomic data with clinical outcome data for tens of thousands of cancer patients treated at multiple institutions worldwide. In conjunction with the first public data release from approximately 19,000 samples, we describe the goals, structure, and data standards of the consortium and report conclusions from high-level analysis of the initial phase of genomic data. We also provide examples of the clinical utility of GENIE data, such as an estimate of clinical actionability across multiple cancer types (>30%) and prediction of accrual rates to the NCI-MATCH trial that accurately reflect recently reported actual match rates. The GENIE database is expected to grow to >100,000 samples within 5 years and should serve as a powerful tool for precision cancer medicine.
Significance: The AACR Project GENIE aims to catalyze sharing of integrated genomic and clinical datasets across multiple institutions worldwide, and thereby enable precision cancer medicine research, including the identification of novel therapeutic targets, design of biomarker-driven clinical trials, and identification of genomic determinants of response to therapy. Cancer Discov; 7(8); 818–31. ©2017 AACR.
See related commentary by Litchfield et al., p. 796.
This article is highlighted in the In This Issue feature, p. 783
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André F. et al. AACR Project GENIE: Powering Precision Medicine through an International Consortium // Cancer Discovery. 2017. Vol. 7. No. 8. pp. 818-831.
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André F. et al. AACR Project GENIE: Powering Precision Medicine through an International Consortium // Cancer Discovery. 2017. Vol. 7. No. 8. pp. 818-831.
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TY - JOUR
DO - 10.1158/2159-8290.cd-17-0151
UR - https://doi.org/10.1158/2159-8290.cd-17-0151
TI - AACR Project GENIE: Powering Precision Medicine through an International Consortium
T2 - Cancer Discovery
AU - André, Fabrice
AU - Arnedos, Mónica
AU - Baras, Alexander S.
AU - Baselga, José
AU - Bedard, Philippe L.
AU - Berger, Michael F.
AU - Bierkens, Mariska
AU - Calvo, Fabien
AU - Cerami, Ethan
AU - Chakravarty, Debyani
AU - Dang, Kristen K
AU - Davidson, Nancy E.
AU - Del Vecchio Fitz, Catherine
AU - Doğan, Semih
AU - Dubois, Raymond N.
AU - Ducar, Matthew D
AU - Futreal, P.Andrew
AU - Gao, Jianjiong
AU - Garcia, Francisco J.
AU - Gardos, Stu
AU - Gocke, Christopher D.
AU - Gross, Benjamin E
AU - Guinney, Justin
AU - Heins, Zachary J
AU - Hintzen, Stephanie
AU - Horlings, Hugo
AU - Hudecek, Jan
AU - Hyman, David M
AU - Kamel-Reid, Suzanne
AU - Kandoth, Cyriac
AU - Kinyua, Walter
AU - Kumari, Priti
AU - Kundra, Ritika
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AU - Lefebvre, Celine
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AU - LU, ZHIBIN
AU - Macconaill, Laura E
AU - Maurer, Ian
AU - Maxwell, David S
AU - Meijer, Gerrit A
AU - Meric-Bernstam, Funda
AU - Micheel, Christine M
AU - Miller, Clinton
AU - Mills, Gordon
AU - Moore, Nathanael D
AU - Nederlof, Petra M
AU - Omberg, Larsson
AU - Orechia, John A
AU - Park, Ben Ho
AU - Pugh, Trevor J.
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AU - Wathoo, Chetna
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AU - Yu, Celeste
AU - Yu, Thomas V
AU - Yu, Emily
AU - Zehir, Ahmet
AU - ZHANG, Hongxin
PY - 2017
DA - 2017/08/01
PB - American Association for Cancer Research (AACR)
SP - 818-831
IS - 8
VL - 7
PMID - 28572459
SN - 2159-8274
SN - 2159-8290
ER -
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@article{2017_André,
author = {Fabrice André and Mónica Arnedos and Alexander S. Baras and José Baselga and Philippe L. Bedard and Michael F. Berger and Mariska Bierkens and Fabien Calvo and Ethan Cerami and Debyani Chakravarty and Kristen K Dang and Nancy E. Davidson and Catherine Del Vecchio Fitz and Semih Doğan and Raymond N. Dubois and Matthew D Ducar and P.Andrew Futreal and Jianjiong Gao and Francisco J. Garcia and Stu Gardos and Christopher D. Gocke and Benjamin E Gross and Justin Guinney and Zachary J Heins and Stephanie Hintzen and Hugo Horlings and Jan Hudecek and David M Hyman and Suzanne Kamel-Reid and Cyriac Kandoth and Walter Kinyua and Priti Kumari and Ritika Kundra and Marc Ladanyi and Celine Lefebvre and Michele L Lenoue Newton and Eva M Lepisto and Mia A Levy and Neal I. Lindeman and James Lindsay and DAVID LIU and ZHIBIN LU and Laura E Macconaill and Ian Maurer and David S Maxwell and Gerrit A Meijer and Funda Meric-Bernstam and Christine M Micheel and Clinton Miller and Gordon Mills and others},
title = {AACR Project GENIE: Powering Precision Medicine through an International Consortium},
journal = {Cancer Discovery},
year = {2017},
volume = {7},
publisher = {American Association for Cancer Research (AACR)},
month = {aug},
url = {https://doi.org/10.1158/2159-8290.cd-17-0151},
number = {8},
pages = {818--831},
doi = {10.1158/2159-8290.cd-17-0151}
}
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André, Fabrice, et al. “AACR Project GENIE: Powering Precision Medicine through an International Consortium.” Cancer Discovery, vol. 7, no. 8, Aug. 2017, pp. 818-831. https://doi.org/10.1158/2159-8290.cd-17-0151.