AMG 510 First to Inhibit “Undruggable” KRAS

Тип публикации: Journal Article

Дата публикации: 2019-08-01

American Association for Cancer Research (AACR)

Cancer Discovery

SCImago Q1

Tоп 10% SCImago

WOS Q1

БС1

SJR: 7.389

CiteScore: 26.9

Impact factor: 29.5

ISSN: 21598274, 21598290

DOI: 10.1158/2159-8290.cd-nb2019-073

Скопировать DOI

PubMed ID: 31189530

Oncology

Краткое описание

Amgen's novel small-molecule inhibitor AMG 510 has become the first drug to successfully target a KRAS mutation in patients, according to findings presented at the 2019 American Society of Clinical Oncology Annual Meeting. In a phase I trial, AMG 510 elicited partial responses in half of evaluable patients with KRASG12C-mutant non–small cell lung cancer, and led to stable disease in most evaluable patients with colorectal or appendix cancer.

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Топ-30

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International Journal of Molecular Sciences	International Journal of Molecular Sciences, 2, 6.25% International Journal of Molecular Sciences 2 публикации, 6.25%
Cancer Discovery	Cancer Discovery, 2, 6.25% Cancer Discovery 2 публикации, 6.25%
European Journal of Medicinal Chemistry	European Journal of Medicinal Chemistry, 2, 6.25% European Journal of Medicinal Chemistry 2 публикации, 6.25%
Russian Chemical Bulletin	Russian Chemical Bulletin, 2, 6.25% Russian Chemical Bulletin 2 публикации, 6.25%
Journal of Clinical Investigation	Journal of Clinical Investigation, 1, 3.13% Journal of Clinical Investigation 1 публикация, 3.13%
Journal of Clinical Medicine	Journal of Clinical Medicine, 1, 3.13% Journal of Clinical Medicine 1 публикация, 3.13%
Virchows Archiv	Virchows Archiv, 1, 3.13% Virchows Archiv 1 публикация, 3.13%
Oncogene	Oncogene, 1, 3.13% Oncogene 1 публикация, 3.13%
Cancer and Metastasis Reviews	Cancer and Metastasis Reviews, 1, 3.13% Cancer and Metastasis Reviews 1 публикация, 3.13%
Trends in Pharmacological Sciences	Trends in Pharmacological Sciences, 1, 3.13% Trends in Pharmacological Sciences 1 публикация, 3.13%
EBioMedicine	EBioMedicine, 1, 3.13% EBioMedicine 1 публикация, 3.13%
Journal of Biological Chemistry	Journal of Biological Chemistry, 1, 3.13% Journal of Biological Chemistry 1 публикация, 3.13%
Computational and Structural Biotechnology Journal	Computational and Structural Biotechnology Journal, 1, 3.13% Computational and Structural Biotechnology Journal 1 публикация, 3.13%
Lung Cancer	Lung Cancer, 1, 3.13% Lung Cancer 1 публикация, 3.13%
Cancer Treatment Reviews	Cancer Treatment Reviews, 1, 3.13% Cancer Treatment Reviews 1 публикация, 3.13%
Life Sciences	Life Sciences, 1, 3.13% Life Sciences 1 публикация, 3.13%
JTO Clinical and Research Reports	JTO Clinical and Research Reports, 1, 3.13% JTO Clinical and Research Reports 1 публикация, 3.13%
Cancer Letters	Cancer Letters, 1, 3.13% Cancer Letters 1 публикация, 3.13%
Seminars in Cancer Biology	Seminars in Cancer Biology, 1, 3.13% Seminars in Cancer Biology 1 публикация, 3.13%
Histopathology	Histopathology, 1, 3.13% Histopathology 1 публикация, 3.13%
ACS Applied Polymer Materials	ACS Applied Polymer Materials, 1, 3.13% ACS Applied Polymer Materials 1 публикация, 3.13%
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Anti-Cancer Agents in Medicinal Chemistry	Anti-Cancer Agents in Medicinal Chemistry, 1, 3.13% Anti-Cancer Agents in Medicinal Chemistry 1 публикация, 3.13%
Frontiers in Oncology	Frontiers in Oncology, 1, 3.13% Frontiers in Oncology 1 публикация, 3.13%
Medicinal Research Reviews	Medicinal Research Reviews, 1, 3.13% Medicinal Research Reviews 1 публикация, 3.13%
International Journal of Cancer	International Journal of Cancer, 1, 3.13% International Journal of Cancer 1 публикация, 3.13%
Biophysics Reviews	Biophysics Reviews, 1, 3.13% Biophysics Reviews 1 публикация, 3.13%
Molecular Biology Reports	Molecular Biology Reports, 1, 3.13% Molecular Biology Reports 1 публикация, 3.13%
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Elsevier	Elsevier, 12, 37.5% Elsevier 12 публикаций, 37.5%
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Wiley	Wiley, 3, 9.38% Wiley 3 публикации, 9.38%
American Association for Cancer Research (AACR)	American Association for Cancer Research (AACR), 2, 6.25% American Association for Cancer Research (AACR) 2 публикации, 6.25%
American Society for Clinical Investigation	American Society for Clinical Investigation, 1, 3.13% American Society for Clinical Investigation 1 публикация, 3.13%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 1, 3.13% American Society for Biochemistry and Molecular Biology 1 публикация, 3.13%
American Chemical Society (ACS)	American Chemical Society (ACS), 1, 3.13% American Chemical Society (ACS) 1 публикация, 3.13%
Bentham Science Publishers Ltd.	Bentham Science Publishers Ltd., 1, 3.13% Bentham Science Publishers Ltd. 1 публикация, 3.13%
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