Follicular Penetration: Development of a Method to Block the Follicles Selectively against the Penetration of Topically Applied Substances
Publication type: Journal Article
Publication date: 2006-05-05
scimago Q1
wos Q1
SJR: 0.833
CiteScore: 6.6
Impact factor: 3.2
ISSN: 16605527, 16605535
PubMed ID:
16679824
General Medicine
Pharmacology
Physiology
Dermatology
Abstract
Investigations into the penetration pathways of topically applied substances through the skin play an important role in dermatological science. Recently, the hair follicles have increasingly been recognized as an important pathway for percutaneous penetration, although the role of the follicles has still not been clarified in detail. Therefore, the aim of the present study was to develop an in vivo method for the analysis of the follicular rate of penetration processes. In order to reach this goal, the follicles were excluded from the penetration process of topically applied substances. Different study designs were evaluated, and we were able to show that the application of nail varnish to each follicular orifice represents an effective method of blocking the follicles selectively against the penetration of topically applied substances. In dermatological science, there is new information on the physiology of skin penetration processes, thus allowing examination of the follicular rate of penetration and improvement of the pharmacokinetics of topically applied substances.
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Metrics
64
Total citations:
64
Citations from 2024:
2
(3.13%)
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MLA
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GOST
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Teichmann A. et al. Follicular Penetration: Development of a Method to Block the Follicles Selectively against the Penetration of Topically Applied Substances // Skin Pharmacology and Physiology. 2006. Vol. 19. No. 4. pp. 216-223.
GOST all authors (up to 50)
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Teichmann A., OTBERG N., Jacobi U., Sterry W. Follicular Penetration: Development of a Method to Block the Follicles Selectively against the Penetration of Topically Applied Substances // Skin Pharmacology and Physiology. 2006. Vol. 19. No. 4. pp. 216-223.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1159/000093117
UR - https://www.karger.com/Article/FullText/93117
TI - Follicular Penetration: Development of a Method to Block the Follicles Selectively against the Penetration of Topically Applied Substances
T2 - Skin Pharmacology and Physiology
AU - Teichmann, Alexa
AU - OTBERG, NINA
AU - Jacobi, Ute
AU - Sterry, Wolfram
PY - 2006
DA - 2006/05/05
PB - S. Karger AG
SP - 216-223
IS - 4
VL - 19
PMID - 16679824
SN - 1660-5527
SN - 1660-5535
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2006_Teichmann,
author = {Alexa Teichmann and NINA OTBERG and Ute Jacobi and Wolfram Sterry},
title = {Follicular Penetration: Development of a Method to Block the Follicles Selectively against the Penetration of Topically Applied Substances},
journal = {Skin Pharmacology and Physiology},
year = {2006},
volume = {19},
publisher = {S. Karger AG},
month = {may},
url = {https://www.karger.com/Article/FullText/93117},
number = {4},
pages = {216--223},
doi = {10.1159/000093117}
}
Cite this
MLA
Copy
Teichmann, Alexa, et al. “Follicular Penetration: Development of a Method to Block the Follicles Selectively against the Penetration of Topically Applied Substances.” Skin Pharmacology and Physiology, vol. 19, no. 4, May. 2006, pp. 216-223. https://www.karger.com/Article/FullText/93117.