Hair Follicles – A Long-Term Reservoir for Drug Delivery
J. Lademann
1
,
Jürgen Lademann
1
,
H. Richter
2
,
Ulrich Schaefer
3
,
Ulrike Blume-Peytavi
2
,
A. Teichmann
2
,
N. Otberg
2
,
W. Sterry
2
Publication type: Journal Article
Publication date: 2006-05-05
scimago Q1
wos Q1
SJR: 0.833
CiteScore: 6.6
Impact factor: 3.2
ISSN: 16605527, 16605535
PubMed ID:
16679826
General Medicine
Pharmacology
Physiology
Dermatology
Abstract
Nanoparticles represent an important drug carrier system. Recently, we have reported on the penetration and storage behavior of particular and non-particular substances revealing the superiority of particular substances in the range of 300–400 nm. In this regard, it was assumed that the rigid hair shaft acts as a geared pump, moving the particles deeper into the hair follicle. In the present investigation, the storage reservoir capacity of the stratum corneum and the hair follicle infundibulum and canal are compared. Interestingly, we could demonstrate a 10 times longer storage within the hair follicles. These results underscore the importance of the hair follicle for drug delivery purposes, mainly highlighting new possibilities for the future concerning retarded delivery, application frequency, and galenic design.
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202
Total citations:
202
Citations from 2024:
19
(9.41%)
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MLA
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GOST
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Lademann J. et al. Hair Follicles – A Long-Term Reservoir for Drug Delivery // Skin Pharmacology and Physiology. 2006. Vol. 19. No. 4. pp. 232-236.
GOST all authors (up to 50)
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Lademann J., Lademann J., Richter H., Schaefer U., Blume-Peytavi U., Teichmann A., Otberg N., Sterry W. Hair Follicles – A Long-Term Reservoir for Drug Delivery // Skin Pharmacology and Physiology. 2006. Vol. 19. No. 4. pp. 232-236.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1159/000093119
UR - https://www.karger.com/Article/FullText/93119
TI - Hair Follicles – A Long-Term Reservoir for Drug Delivery
T2 - Skin Pharmacology and Physiology
AU - Lademann, J.
AU - Lademann, Jürgen
AU - Richter, H.
AU - Schaefer, Ulrich
AU - Blume-Peytavi, Ulrike
AU - Teichmann, A.
AU - Otberg, N.
AU - Sterry, W.
PY - 2006
DA - 2006/05/05
PB - S. Karger AG
SP - 232-236
IS - 4
VL - 19
PMID - 16679826
SN - 1660-5527
SN - 1660-5535
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2006_Lademann,
author = {J. Lademann and Jürgen Lademann and H. Richter and Ulrich Schaefer and Ulrike Blume-Peytavi and A. Teichmann and N. Otberg and W. Sterry},
title = {Hair Follicles – A Long-Term Reservoir for Drug Delivery},
journal = {Skin Pharmacology and Physiology},
year = {2006},
volume = {19},
publisher = {S. Karger AG},
month = {may},
url = {https://www.karger.com/Article/FullText/93119},
number = {4},
pages = {232--236},
doi = {10.1159/000093119}
}
Cite this
MLA
Copy
Lademann, J., et al. “Hair Follicles – A Long-Term Reservoir for Drug Delivery.” Skin Pharmacology and Physiology, vol. 19, no. 4, May. 2006, pp. 232-236. https://www.karger.com/Article/FullText/93119.