Follicular Penetration of Topically Applied Caffeine via a Shampoo Formulation
Publication type: Journal Article
Publication date: 2007-03-30
scimago Q1
wos Q1
SJR: 0.833
CiteScore: 6.6
Impact factor: 3.2
ISSN: 16605527, 16605535
PubMed ID:
17396054
General Medicine
Pharmacology
Physiology
Dermatology
Abstract
<i>Aims:</i> Follicular drug delivery is the prerequisite for an effective treatment of androgenetic alopecia or other reasons of premature hair loss. <i>Methods:</i> The follicular penetration of caffeine, applied topically in a shampoo formulation for 2 min, was measured with highly sensitive surface ionization in combination with mass spectroscopy, a selective method for the detection of very small quantities of transcutaneously absorbed substances in the blood. An experimental protocol, developed to selectively block the follicular pathway within the test area, was used. Based on this principle, a clear distinction between interfollicular and follicular penetration of topically applied caffeine was feasible. <i>Results:</i> After 2 min, caffeine penetrated via the hair follicles and stratum corneum. <i>Conclusion:</i> It was found that the penetration via hair follicles was faster and higher compared with the interfollicular route and that hair follicles are the only pathway for fast caffeine absorption during the first 20 min after application.
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Metrics
70
Total citations:
70
Citations from 2024:
9
(12.85%)
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GOST
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Otberg N. et al. Follicular Penetration of Topically Applied Caffeine via a Shampoo Formulation // Skin Pharmacology and Physiology. 2007. Vol. 20. No. 4. pp. 195-198.
GOST all authors (up to 50)
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Otberg N., Teichmann A., Rasuljev U., Sinkgraven R., Sterry W., Lademann J. Follicular Penetration of Topically Applied Caffeine via a Shampoo Formulation // Skin Pharmacology and Physiology. 2007. Vol. 20. No. 4. pp. 195-198.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1159/000101389
UR - https://www.karger.com/Article/FullText/101389
TI - Follicular Penetration of Topically Applied Caffeine via a Shampoo Formulation
T2 - Skin Pharmacology and Physiology
AU - Otberg, N.
AU - Teichmann, A.
AU - Rasuljev, U.
AU - Sinkgraven, R.
AU - Sterry, W.
AU - Lademann, Jürgen
PY - 2007
DA - 2007/03/30
PB - S. Karger AG
SP - 195-198
IS - 4
VL - 20
PMID - 17396054
SN - 1660-5527
SN - 1660-5535
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2007_Otberg,
author = {N. Otberg and A. Teichmann and U. Rasuljev and R. Sinkgraven and W. Sterry and Jürgen Lademann},
title = {Follicular Penetration of Topically Applied Caffeine via a Shampoo Formulation},
journal = {Skin Pharmacology and Physiology},
year = {2007},
volume = {20},
publisher = {S. Karger AG},
month = {mar},
url = {https://www.karger.com/Article/FullText/101389},
number = {4},
pages = {195--198},
doi = {10.1159/000101389}
}
Cite this
MLA
Copy
Otberg, N., et al. “Follicular Penetration of Topically Applied Caffeine via a Shampoo Formulation.” Skin Pharmacology and Physiology, vol. 20, no. 4, Mar. 2007, pp. 195-198. https://www.karger.com/Article/FullText/101389.