,
volume 206
,
issue 11
,
pages 1326-1335
Home High-Flow Nasal Cannula Oxygen Therapy for Stable Hypercapnic COPD: A Randomized Clinical Trial
Kazuma Nagata
1
,
Takeo HORIE
2
,
Naohiko CHOHNABAYASHI
3
,
Torahiko Jinta
3
,
Ryosuke Tsugitomi
3
,
Akira Shiraki
4
,
Fumiaki Tokioka
5
,
Toru Kadowaki
6
,
Akira Watanabe
7
,
Motonari Fukui
8
,
Takamasa Kitajima
8
,
Atsuyasu SATO
9
,
Toru Tsuda
10
,
Nobuhito Kishimoto
11
,
Hideo Kita
12
,
Yoshihiro MORI
13
,
Masayuki Nakayama
14
,
KENICHI TAKAHASHI
15
,
Tomomasa Tsuboi
16
,
Makoto Yoshida
17
,
Osamu HATAJI
18
,
Satoshi Fuke
19
,
Michiko Kagajo
4
,
Hiroki Nishine
20
,
Hiroyasu KOBAYASHI
21
,
Hiroyuki Nakamura
22
,
Miyuki Okuda
23
,
Sayaka Tachibana
24
,
Shohei Takata
25
,
Hisayuki Osoreda
26
,
Kenichi Minami
27
,
TAKASHI NISHIMURA
28
,
Tadashi Ishida
5
,
Jiro Terada
29
,
Naoko Takeuchi
30
,
Yasuo Kohashi
31
,
Hiromasa Inoue
32
,
Yoko Nakagawa
33
,
TAKASHI KIKUCHI
33
,
Keisuke Tomii
1
1
2
Department of Respiratory Medicine, Japanese Red Cross Maebashi Hospital, Maebashi, Gunma, Japan;
|
6
Department of Pulmonary Medicine, National Hospital Organization Matsue Medical Center, Matsue, Shimane, Japan;
|
7
Department of Respiratory Medicine, National Hospital Organization Ehime Medical Center, Toon, Ehime, Japan;
|
10
Kirigaoka Tsuda Hospital, Kitakyushu, Fukuoka, Japan;
|
11
Department of Respiratory Medicine, Takamastu Municipal Hospital, Takamatsu, Kagawa, Japan;
|
12
Department of Respiratory Medicine, Takatsuki Red Cross Hospital, Takatsuki, Osaka, Japan;
|
13
Department of Respiratory Medicine, KKR Takamatsu Hospital, Takamatsu, Kagawa, Japan;
|
15
Department of Respiratory Medicine, Kishiwada City Hospital, Kishiwada, Osaka, Japan;
|
16
Department of Respiratory Medicine, National Hospital Organization Minami Kyoto Hospital, Joyo, Kyoto, Japan;
|
17
Department of Respiratory Medicine, National Hospital Organization Fukuoka National Hospital, Fukuoka, Fukuoka, Japan;
|
18
Respiratory Center, Matsusaka Municipal Hospital, Matsusaka, Mie, Japan;
|
19
Department of Respiratory Medicine, KKR Sapporo Medical Center, Sapporo, Hokkaido, Japan;
|
21
Respiratory Center, Suzuka General Hospital, Suzuka, Mie, Japan;
|
22
Department of Respiratory Medicine, Sakaide City Hospital, Sakaide, Kagawa, Japan;
|
23
Osaka Anti-Tuberculosis Association Osaka Hospital, Neyagawa, Osaka, Japan;
|
24
25
Department of Respiratory Medicine, National Hospital Organization Fukuokahigashi Medical Center, Koga, Fukuoka, Japan;
|
26
Department of Respiratory Medicine, National Hospital Organization Yamaguchi-Ube Medical Center, Ube, Yamaguchi, Japan;
|
27
Department of Respiratory Medicine, Ishikiriseiki Hospital, Higashi-osaka, Osaka, Japan;
|
28
Department of Respiratory Medicine, Kyoto Katsura Hospital, Kyoto, Kyoto, Japan;
|
30
Department of Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Osaka, Japan;
|
31
Department of Respiratory Medicine, HARUHI Respiratory Medical Hospital, Kiyosu, Aichi, Japan;
|
33
Division of Medical Statistics, Translational Research Center for Medical Innovation, Foundation for Biomedical Research and Innovation at Kobe, Kobe, Hyogo, Japan
|
Publication type: Journal Article
Publication date: 2022-06-30
scimago Q1
wos Q1
SJR: 5.076
CiteScore: 23.8
Impact factor: 19.4
ISSN: 1073449X, 15354970
PubMed ID:
35771533
Critical Care and Intensive Care Medicine
Pulmonary and Respiratory Medicine
Abstract
Rationale: The long-term effects of using a high-flow nasal cannula for chronic hypercapnic respiratory failure caused by chronic obstructive pulmonary disease remain unclear. Objectives: To assess whether long-term high-flow nasal cannula use reduces the number of exacerbations and improves other physiological parameters in patients with chronic hypercapnic respiratory failure caused by chronic obstructive pulmonary disease. Methods: We enrolled 104 participants (aged ⩾40 yr) with daytime hypercapnia (Global Initiative for Chronic Obstructive Lung Disease stages 2-4) receiving long-term oxygen therapy (⩾16 h/d for ⩾1 mo) and randomly assigned them to high-flow nasal cannula/long-term oxygen therapy and long-term oxygen therapy groups. The primary endpoint was the moderate or severe exacerbation rate. We compared changes from baseline in arterial blood gas values, peripheral oxygen saturation, pulmonary function, health-related quality-of-life scores, and the 6-minute-walk test. Measurements and Main Results: High-flow nasal cannula use significantly reduced the rate of moderate/severe exacerbations (unadjusted mean count 1.0 vs. 2.5, a ratio of the adjusted mean count between groups [95% confidence interval] of 2.85 [1.48-5.47]) and prolonged the duration without moderate or severe exacerbations. The median time to first moderate or severe exacerbation in the long-term oxygen therapy group was 25 (14.1-47.4) weeks; this was not reached in the high-flow nasal cannula/long-term oxygen therapy group. High-flow nasal cannula use significantly improved health-related quality of life scores, peripheral oxygen saturation, and specific pulmonary function parameters. No safety concerns were identified. Conclusions: A high-flow nasal cannula is a reasonable therapeutic option for patients with stable hypercapnic chronic obstructive pulmonary disease and a history of exacerbations. Clinical trial registered with www.umin/ac.jp (UMIN000028581) and www.clinicaltrials.gov (NCT03282019).
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Metrics
82
Total citations:
82
Citations from 2024:
53
(64.64%)
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GOST
Copy
Nagata K. et al. Home High-Flow Nasal Cannula Oxygen Therapy for Stable Hypercapnic COPD: A Randomized Clinical Trial // American Journal of Respiratory and Critical Care Medicine. 2022. Vol. 206. No. 11. pp. 1326-1335.
GOST all authors (up to 50)
Copy
Nagata K., HORIE T., CHOHNABAYASHI N., Jinta T., Tsugitomi R., Shiraki A., Tokioka F., Kadowaki T., Watanabe A., Fukui M., Kitajima T., SATO A., Tsuda T., Kishimoto N., Kita H., MORI Y., Nakayama M., TAKAHASHI K., Tsuboi T., Yoshida M., HATAJI O., Fuke S., Kagajo M., Nishine H., KOBAYASHI H., Nakamura H., Okuda M., Tachibana S., Takata S., Osoreda H., Minami K., NISHIMURA T., Ishida T., Terada J., Takeuchi N., Kohashi Y., Inoue H., Nakagawa Y., KIKUCHI T., Tomii K. Home High-Flow Nasal Cannula Oxygen Therapy for Stable Hypercapnic COPD: A Randomized Clinical Trial // American Journal of Respiratory and Critical Care Medicine. 2022. Vol. 206. No. 11. pp. 1326-1335.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1164/rccm.202201-0199OC
UR - https://doi.org/10.1164/rccm.202201-0199OC
TI - Home High-Flow Nasal Cannula Oxygen Therapy for Stable Hypercapnic COPD: A Randomized Clinical Trial
T2 - American Journal of Respiratory and Critical Care Medicine
AU - Nagata, Kazuma
AU - HORIE, Takeo
AU - CHOHNABAYASHI, Naohiko
AU - Jinta, Torahiko
AU - Tsugitomi, Ryosuke
AU - Shiraki, Akira
AU - Tokioka, Fumiaki
AU - Kadowaki, Toru
AU - Watanabe, Akira
AU - Fukui, Motonari
AU - Kitajima, Takamasa
AU - SATO, Atsuyasu
AU - Tsuda, Toru
AU - Kishimoto, Nobuhito
AU - Kita, Hideo
AU - MORI, Yoshihiro
AU - Nakayama, Masayuki
AU - TAKAHASHI, KENICHI
AU - Tsuboi, Tomomasa
AU - Yoshida, Makoto
AU - HATAJI, Osamu
AU - Fuke, Satoshi
AU - Kagajo, Michiko
AU - Nishine, Hiroki
AU - KOBAYASHI, Hiroyasu
AU - Nakamura, Hiroyuki
AU - Okuda, Miyuki
AU - Tachibana, Sayaka
AU - Takata, Shohei
AU - Osoreda, Hisayuki
AU - Minami, Kenichi
AU - NISHIMURA, TAKASHI
AU - Ishida, Tadashi
AU - Terada, Jiro
AU - Takeuchi, Naoko
AU - Kohashi, Yasuo
AU - Inoue, Hiromasa
AU - Nakagawa, Yoko
AU - KIKUCHI, TAKASHI
AU - Tomii, Keisuke
PY - 2022
DA - 2022/06/30
PB - American Thoracic Society
SP - 1326-1335
IS - 11
VL - 206
PMID - 35771533
SN - 1073-449X
SN - 1535-4970
ER -
Cite this
BibTex (up to 50 authors)
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@article{2022_Nagata,
author = {Kazuma Nagata and Takeo HORIE and Naohiko CHOHNABAYASHI and Torahiko Jinta and Ryosuke Tsugitomi and Akira Shiraki and Fumiaki Tokioka and Toru Kadowaki and Akira Watanabe and Motonari Fukui and Takamasa Kitajima and Atsuyasu SATO and Toru Tsuda and Nobuhito Kishimoto and Hideo Kita and Yoshihiro MORI and Masayuki Nakayama and KENICHI TAKAHASHI and Tomomasa Tsuboi and Makoto Yoshida and Osamu HATAJI and Satoshi Fuke and Michiko Kagajo and Hiroki Nishine and Hiroyasu KOBAYASHI and Hiroyuki Nakamura and Miyuki Okuda and Sayaka Tachibana and Shohei Takata and Hisayuki Osoreda and Kenichi Minami and TAKASHI NISHIMURA and Tadashi Ishida and Jiro Terada and Naoko Takeuchi and Yasuo Kohashi and Hiromasa Inoue and Yoko Nakagawa and TAKASHI KIKUCHI and Keisuke Tomii},
title = {Home High-Flow Nasal Cannula Oxygen Therapy for Stable Hypercapnic COPD: A Randomized Clinical Trial},
journal = {American Journal of Respiratory and Critical Care Medicine},
year = {2022},
volume = {206},
publisher = {American Thoracic Society},
month = {jun},
url = {https://doi.org/10.1164/rccm.202201-0199OC},
number = {11},
pages = {1326--1335},
doi = {10.1164/rccm.202201-0199OC}
}
Cite this
MLA
Copy
Nagata, Kazuma, et al. “Home High-Flow Nasal Cannula Oxygen Therapy for Stable Hypercapnic COPD: A Randomized Clinical Trial.” American Journal of Respiratory and Critical Care Medicine, vol. 206, no. 11, Jun. 2022, pp. 1326-1335. https://doi.org/10.1164/rccm.202201-0199OC.
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