SAGE
Lupus
,  volume 34 ,  issue 3 ,  pages 307-311

Hypertension is associated with global and renal damage accrual in patients with systemic lupus erythematosus. Data from the Almenara Lupus Cohort

Fernando Piero Díaz-Ramírez 1
, 
Fiorella Vanessa Saldaña-Alvarado 1
, 
Rocío V. Gamboa-Cárdenas 1, 2
, 
Victor R. Pimentel-Quiroz 1, 2
, 
Cristina Reátegui-Sokolova 1, 3
, 
Claudia Elera-Fitzcarrald 1, 4
, 
Erika Noriega 1, 5
, 
Zoila Rodriguez-Bellido 1, 6
, 
Cesar Pastor-Asurza 1, 6
, 
Risto Perich-Campos 1, 6
, 
G S Alarcón 7, 8
, 
Manuel F. Ugarte-Gil 1, 2
1
 
2
 
Department of Rheumatology, Hospital Guillermo Almenara Irigoyen - EsSalud, Lima, Perú
3
 
4
 
5
 
6
 
7
 
8
 
Publication type: Journal Article
Publication date: 2025-02-08
SAGE
scimago Q2
wos Q3
SJR: 0.779
CiteScore: 4.1
Impact factor: 1.9
ISSN: 09612033, 14770962
Abstract
Objectives

To determine the association between the occurrence of hypertension and damage accrual in patients with systemic lupus erythematosus (SLE).

Materials and methods

From January 2012 to January 2020, we evaluated 314 SLE patients, all members of the Almenara Lupus Cohort. We applied the American College of Cardiology/American Heart Association (ACC/AHA) guidelines to define hypertension, the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) to determine organ damage, and the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI-2K) to assess disease activity. We performed univariable and multivariable analysis using generalized estimating equations, adjusting for potential confounders (demographic factors, disease-related factors and treatment).

Results

314 patients and 1695 visits were included; 93% of the patients were women. Their mean disease duration was of 6.8 years (SD: 6.4), and their age at diagnosis of 35.7 (SD: 13.4) years. Baseline damage was 0.8 (SD: 1.2) at the first visit, increasing by 0.15 points at the subsequent follow-up visit (SD: 0.46). The prevalence of hypertension in these patients was 56.4% at least once during their follow-up. In the multivariable analysis, hypertension remained associated with damage accrual (IRR: 1.645, 95% CI: 1.187–2.280, p = 0.003) after adjusting for confounders. In the analyses performed per domain, hypertension was associated with renal damage in the multivariable model (OR: 4.331, 95% CI 1.547–12.126, p = 0.005).

Conclusion

Hypertension was associated with subsequent greater damage in our SLE patients. Thus, providers involved on the care of these patients should monitor their blood pressure at all clinic visits.

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GOST Copy
Díaz-Ramírez F. P. et al. Hypertension is associated with global and renal damage accrual in patients with systemic lupus erythematosus. Data from the Almenara Lupus Cohort // Lupus. 2025. Vol. 34. No. 3. pp. 307-311.
GOST all authors (up to 50) Copy
Díaz-Ramírez F. P., Saldaña-Alvarado F. V., Gamboa-Cárdenas R. V., Pimentel-Quiroz V. R., Reátegui-Sokolova C., Elera-Fitzcarrald C., Noriega E., Rodriguez-Bellido Z., Pastor-Asurza C., Perich-Campos R., Alarcón G. S., Ugarte-Gil M. F. Hypertension is associated with global and renal damage accrual in patients with systemic lupus erythematosus. Data from the Almenara Lupus Cohort // Lupus. 2025. Vol. 34. No. 3. pp. 307-311.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1177/09612033251319397
UR - https://journals.sagepub.com/doi/10.1177/09612033251319397
TI - Hypertension is associated with global and renal damage accrual in patients with systemic lupus erythematosus. Data from the Almenara Lupus Cohort
T2 - Lupus
AU - Díaz-Ramírez, Fernando Piero
AU - Saldaña-Alvarado, Fiorella Vanessa
AU - Gamboa-Cárdenas, Rocío V.
AU - Pimentel-Quiroz, Victor R.
AU - Reátegui-Sokolova, Cristina
AU - Elera-Fitzcarrald, Claudia
AU - Noriega, Erika
AU - Rodriguez-Bellido, Zoila
AU - Pastor-Asurza, Cesar
AU - Perich-Campos, Risto
AU - Alarcón, G S
AU - Ugarte-Gil, Manuel F.
PY - 2025
DA - 2025/02/08
PB - SAGE
SP - 307-311
IS - 3
VL - 34
SN - 0961-2033
SN - 1477-0962
ER -
BibTex |
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BibTex (up to 50 authors) Copy
@article{2025_Díaz-Ramírez,
author = {Fernando Piero Díaz-Ramírez and Fiorella Vanessa Saldaña-Alvarado and Rocío V. Gamboa-Cárdenas and Victor R. Pimentel-Quiroz and Cristina Reátegui-Sokolova and Claudia Elera-Fitzcarrald and Erika Noriega and Zoila Rodriguez-Bellido and Cesar Pastor-Asurza and Risto Perich-Campos and G S Alarcón and Manuel F. Ugarte-Gil},
title = {Hypertension is associated with global and renal damage accrual in patients with systemic lupus erythematosus. Data from the Almenara Lupus Cohort},
journal = {Lupus},
year = {2025},
volume = {34},
publisher = {SAGE},
month = {feb},
url = {https://journals.sagepub.com/doi/10.1177/09612033251319397},
number = {3},
pages = {307--311},
doi = {10.1177/09612033251319397}
}
MLA
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MLA Copy
Díaz-Ramírez, Fernando Piero, et al. “Hypertension is associated with global and renal damage accrual in patients with systemic lupus erythematosus. Data from the Almenara Lupus Cohort.” Lupus, vol. 34, no. 3, Feb. 2025, pp. 307-311. https://journals.sagepub.com/doi/10.1177/09612033251319397.