SAGE
Journal of Alzheimer's Disease
,  volume 104 ,  issue 1 ,  pages 245-254

Adherence to intervention components: The key to success? Analysis on health-related outcomes of the AgeWell.de intervention to preserve cognition

Felix G. Wittmann 1
, 
A. Pabst 1
, 
Andrea Zülke 1
, 
Melanie Luppa 1
, 
Maria Isabel Cardona 2
, 
Melanie Boekholt 2
, 
Thomas Fankhänel 3
, 
Solveig Carmienke 3
, 
Robert Kosilek 4
, 
Linda Sanftenberg 4
, 
Christian Brettschneider 5
, 
Juliane Döhring 6
, 
Martin Williamson 6
, 
Birgitt Wiese 7
, 
Jochen René Thyrian 2, 8, 9
, 
Wolfgang Hoffmann 2, 8
, 
Jochen Gensichen 4
, 
Katharina Piontek 5
, 
Hanna Kaduszkiewicz 6
, 
Thomas Frese 3
, 
Steffi G. Riedel-Heller 1
1
 
2
 
3
 
4
 
5
 
6
 
7
 
8
 
9
 
Publication type: Journal Article
Publication date: 2025-02-09
SAGE
scimago Q1
wos Q2
SJR: 1.166
CiteScore: 6.1
Impact factor: 3.1
ISSN: 13872877, 18758908
Abstract
Background

The aim of the study was to analyze the impact of adherence to the intervention components on the effectiveness of AgeWell.de, a multi-domain lifestyle intervention against cognitive decline, on function in everyday activities, quality of life, depressiveness and social isolation.

Objective

Studying the effect of adherence on health-related outcomes.

Methods

Participants were aged 60–77 years at baseline and at risk (Cardiovascular Risk Factors, Ageing and Dementia Score (CAIDE) ≥9). Adherence to the components nutrition, enhancement of physical and social activities and cognitive training was analyzed in two ways, first continual within the intervention group (n = 378, mean age = 69.1 years, 52.7% female) and second as dichotomous split (75% adherence) and in reference to the control group (received infomaterial and regular health advice; n = 441, mean age = 69 years, 53% female). Generalized linear regression models were then run on the health outcomes functioning in everyday activities, quality of life, depressive symptoms, and social inclusion.

Results

Health-related quality of life and depressiveness were improved in participants with better adherence to nutritional counselling and enhancement of physical and social activities. Better adherence to social activities was relevant for function in everyday activities. Effects of high adherence to cognitive training was found for improvements in depressiveness when comparing it to the control group. No effect was found on social inclusion when considering the particular components.

Conclusions

The extent of adherence to most components influenced health-related outcomes such as health-related quality of life and depressiveness. With this study, the effectiveness of AgeWell.de can be understood in greater depth.

Trial Registration

German Clinical Trial Register (DRKS; ID: DRKS00013555).

Found 
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GOST Copy
Wittmann F. G. et al. Adherence to intervention components: The key to success? Analysis on health-related outcomes of the AgeWell.de intervention to preserve cognition // Journal of Alzheimer's Disease. 2025. Vol. 104. No. 1. pp. 245-254.
GOST all authors (up to 50) Copy
Wittmann F. G., Pabst A., Zülke A., Luppa M., Cardona M. I., Boekholt M., Fankhänel T., Carmienke S., Kosilek R., Sanftenberg L., Brettschneider C., Döhring J., Williamson M., Wiese B., Thyrian J. R., Hoffmann W., Gensichen J., Piontek K., Kaduszkiewicz H., Frese T., Riedel-Heller S. G. Adherence to intervention components: The key to success? Analysis on health-related outcomes of the AgeWell.de intervention to preserve cognition // Journal of Alzheimer's Disease. 2025. Vol. 104. No. 1. pp. 245-254.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1177/13872877251314892
UR - https://journals.sagepub.com/doi/10.1177/13872877251314892
TI - Adherence to intervention components: The key to success? Analysis on health-related outcomes of the AgeWell.de intervention to preserve cognition
T2 - Journal of Alzheimer's Disease
AU - Wittmann, Felix G.
AU - Pabst, A.
AU - Zülke, Andrea
AU - Luppa, Melanie
AU - Cardona, Maria Isabel
AU - Boekholt, Melanie
AU - Fankhänel, Thomas
AU - Carmienke, Solveig
AU - Kosilek, Robert
AU - Sanftenberg, Linda
AU - Brettschneider, Christian
AU - Döhring, Juliane
AU - Williamson, Martin
AU - Wiese, Birgitt
AU - Thyrian, Jochen René
AU - Hoffmann, Wolfgang
AU - Gensichen, Jochen
AU - Piontek, Katharina
AU - Kaduszkiewicz, Hanna
AU - Frese, Thomas
AU - Riedel-Heller, Steffi G.
PY - 2025
DA - 2025/02/09
PB - SAGE
SP - 245-254
IS - 1
VL - 104
SN - 1387-2877
SN - 1875-8908
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2025_Wittmann,
author = {Felix G. Wittmann and A. Pabst and Andrea Zülke and Melanie Luppa and Maria Isabel Cardona and Melanie Boekholt and Thomas Fankhänel and Solveig Carmienke and Robert Kosilek and Linda Sanftenberg and Christian Brettschneider and Juliane Döhring and Martin Williamson and Birgitt Wiese and Jochen René Thyrian and Wolfgang Hoffmann and Jochen Gensichen and Katharina Piontek and Hanna Kaduszkiewicz and Thomas Frese and Steffi G. Riedel-Heller},
title = {Adherence to intervention components: The key to success? Analysis on health-related outcomes of the AgeWell.de intervention to preserve cognition},
journal = {Journal of Alzheimer's Disease},
year = {2025},
volume = {104},
publisher = {SAGE},
month = {feb},
url = {https://journals.sagepub.com/doi/10.1177/13872877251314892},
number = {1},
pages = {245--254},
doi = {10.1177/13872877251314892}
}
MLA
Cite this
MLA Copy
Wittmann, Felix G., et al. “Adherence to intervention components: The key to success? Analysis on health-related outcomes of the AgeWell.de intervention to preserve cognition.” Journal of Alzheimer's Disease, vol. 104, no. 1, Feb. 2025, pp. 245-254. https://journals.sagepub.com/doi/10.1177/13872877251314892.