PRP Injections for the Treatment of Knee Osteoarthritis: The Improvement Is Clinically Significant and Influenced by Platelet Concentration: A Meta-analysis of Randomized Controlled Trials
Background:
Platelet-rich plasma (PRP) has emerged as a promising therapeutic intervention for knee osteoarthritis (OA), attracting substantial clinical and research attention. However, the clinical relevance of the treatment benefit remains controversial.
Purpose:
To evaluate the effectiveness of PRP compared with placebo in patients with knee OA in terms of minimal clinically important difference (MCID) and to investigate the possible influence of platelet concentration on the clinical outcome.
Study Design:
Meta-analysis. Level of evidence 1.
Methods:
The search was conducted on 5 databases (PubMed, Cochrane Library, Scopus, Embase, Web of Science) using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Inclusion criteria were randomized controlled trials comparing PRP and placebo injections to treat knee OA, written in the English language, with no time limitation. The effects were quantified at 1-, 3-, 6-, and 12-month follow-up points. Visual analog scale (VAS) for pain and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores were used, with subanalyses based on platelet concentration performed using a 1,000,000 ± 20% platelets/µL cutoff. The MCID values (VAS, 1.37; WOMAC, 6.4) were used to interpret clinical improvement. The articles’ quality was assessed using the Revised Tool for Risk of Bias in Randomized Trials and the Grading of Recommendations Assessment, Development and Evaluation guidelines.
Results:
Among the 5499 articles retrieved, 18 randomized controlled trials (1995 patients) were included. PRP presented statistically superior improvements in VAS and WOMAC scores compared with placebo at all follow-up points, exceeding the MCID at 3- and 6-month follow-up points for VAS and at all follow-up points for WOMAC. The subanalysis based on platelet concentration showed that high-platelet PRP provided clinically significant pain relief with the improvement exceeding the MCID compared with placebo at 3-, 6-, and 12-month follow-up points. In contrast, low-platelet PRP failed to offer a clinically perceivable benefit in terms of VAS score. WOMAC results showed that both products provided a clinically significant improvement at 3 and 6 months of follow-up. This benefit was maintained up to the 12-month follow-up in the high-platelet group but not in the low-platelet group, where the improvement compared with placebo did not reach statistical significance.
Conclusion:
This meta-analysis showed that PRP offered clinically relevant functional improvement at 1-, 3-, 6-, and 12-month follow-up points and pain relief at 3- and 6-month follow-up points compared with placebo for the treatment of knee OA. Platelet concentration was found to influence treatment efficacy, with high-platelet PRP providing superior pain relief and more durable functional improvement compared with low-platelet PRP.
Топ-30
Журналы
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American Journal of Sports Medicine
8 публикаций, 11.94%
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Journal of Clinical Medicine
3 публикации, 4.48%
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Knee Surgery, Sports Traumatology, Arthroscopy
3 публикации, 4.48%
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Revue du Rhumatisme (Edition Francaise)
2 публикации, 2.99%
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Joint Bone Spine
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Cureus
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Regenerative Therapy
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Seminars in Arthroplasty
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Advanced healthcare materials
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Frontiers in Medicine
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Clinics in Sports Medicine
1 публикация, 1.49%
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Journal de Traumatologie du Sport
1 публикация, 1.49%
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Journal of Arthroplasty
1 публикация, 1.49%
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Biomolecules
1 публикация, 1.49%
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International Journal of Translational Medicine
1 публикация, 1.49%
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Acta Biomaterialia
1 публикация, 1.49%
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Cartilage
1 публикация, 1.49%
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Bone & Joint Open
1 публикация, 1.49%
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Arthroscopy - Journal of Arthroscopic and Related Surgery
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Journal of Experimental Orthopaedics
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Current Opinion in Obstetrics and Gynecology
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Rehabilitacion
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Frontiers in Physiology
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European Journal of Medical Research
1 публикация, 1.49%
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Journal of Translational Medicine
1 публикация, 1.49%
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Skeletal Radiology
1 публикация, 1.49%
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Interventional Pain Medicine
1 публикация, 1.49%
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Sports Orthopaedics and Traumatology
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Open Access Journal of Sports Medicine
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Gefasschirurgie
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Издатели
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Elsevier
19 публикаций, 28.36%
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Springer Nature
12 публикаций, 17.91%
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SAGE
9 публикаций, 13.43%
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MDPI
8 публикаций, 11.94%
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Wiley
8 публикаций, 11.94%
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Frontiers Media S.A.
5 публикаций, 7.46%
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Ovid Technologies (Wolters Kluwer Health)
3 публикации, 4.48%
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Taylor & Francis
2 публикации, 2.99%
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British Editorial Society of Bone and Joint Surgery
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