volume 33 issue 2 pages 161-169

Alginate hydrogel co-loaded with cisplatin and gold nanoparticles for computed tomography image-guided chemotherapy

Publication typeJournal Article
Publication date2018-06-22
scimago Q3
wos Q3
SJR0.525
CiteScore6.0
Impact factor2.5
ISSN08853282, 15308022
Biomaterials
Biomedical Engineering
Abstract

The biomedical applications of gold nanoparticles (AuNPs) have experienced rapid growth in recent years, due to their expected benefits in medical imaging and therapy. In this work, we report the development of a theranostic nanocomplex constructed from alginate hydrogel co-loaded with cisplatin and AuNPs (abbreviated as ACA) for simultaneous drug delivery and computed tomography imaging. CT26 cells derived from mouse colon adenocarcinoma were exposed to various concentrations of ACA nanocomplex (for 24 h) and the cytotoxicity was measured using MTT assay. Moreover, the cells treated with ACA nanocomplex were imaged in a computed tomography scanner and the contrast enhancement due to the presence of nanocomplex was assessed. The cytotoxicity results showed that ACA nanocomplex had a more potent chemotherapy efficacy than free cisplatin, so that ACA nanocomplex at the concentration of 5 µg/ml (per cisplatin) and 20 µg/ml of free cisplatin resulted in the same cytotoxicity (survival rate: 66%). The computed tomography imaging study revealed that ACA nanocomplex increased the brightness of computed tomography images, the computed tomography number value, and contrast-to-noise ratio (CNR). ACA nanocomplex can be presented as a computed tomography-traceable nanocarrier that allows to monitor the delivery of therapeutics by assessing their localized accumulation and in vivo biodistribution.

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GOST |
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GOST Copy
Keshavarz M. et al. Alginate hydrogel co-loaded with cisplatin and gold nanoparticles for computed tomography image-guided chemotherapy // Journal of Biomaterials Applications. 2018. Vol. 33. No. 2. pp. 161-169.
GOST all authors (up to 50) Copy
Keshavarz M., Moloudi K., Paydar R., Abed Z., Beik J., Ghaznavi H., Shakeri-Zadeh A. Alginate hydrogel co-loaded with cisplatin and gold nanoparticles for computed tomography image-guided chemotherapy // Journal of Biomaterials Applications. 2018. Vol. 33. No. 2. pp. 161-169.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1177/0885328218782355
UR - https://doi.org/10.1177/0885328218782355
TI - Alginate hydrogel co-loaded with cisplatin and gold nanoparticles for computed tomography image-guided chemotherapy
T2 - Journal of Biomaterials Applications
AU - Keshavarz, Marzieh
AU - Moloudi, Kave
AU - Paydar, Reza
AU - Abed, Ziaeddin
AU - Beik, Jaber
AU - Ghaznavi, Habib
AU - Shakeri-Zadeh, Ali
PY - 2018
DA - 2018/06/22
PB - SAGE
SP - 161-169
IS - 2
VL - 33
PMID - 29933708
SN - 0885-3282
SN - 1530-8022
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2018_Keshavarz,
author = {Marzieh Keshavarz and Kave Moloudi and Reza Paydar and Ziaeddin Abed and Jaber Beik and Habib Ghaznavi and Ali Shakeri-Zadeh},
title = {Alginate hydrogel co-loaded with cisplatin and gold nanoparticles for computed tomography image-guided chemotherapy},
journal = {Journal of Biomaterials Applications},
year = {2018},
volume = {33},
publisher = {SAGE},
month = {jun},
url = {https://doi.org/10.1177/0885328218782355},
number = {2},
pages = {161--169},
doi = {10.1177/0885328218782355}
}
MLA
Cite this
MLA Copy
Keshavarz, Marzieh, et al. “Alginate hydrogel co-loaded with cisplatin and gold nanoparticles for computed tomography image-guided chemotherapy.” Journal of Biomaterials Applications, vol. 33, no. 2, Jun. 2018, pp. 161-169. https://doi.org/10.1177/0885328218782355.