Open Access
Synthesis and сytotoxicity of a-azepanobetulinic acid N-methyl-piperazinylamide
Gulnara V Giniyatullina
1
,
Oxana B. Kazakova
1
,
Irina P Baikova
1
,
Emil Yu Yamansarov
2
,
Ilya A. Osterman
2, 3, 4
,
Ekaterina S. Komarova
2, 3
,
Irina V Saltikova
2
,
Alexander G. Majouga
2, 5, 6
,
Yan A Ivanenkov
7, 8
7
Publication type: Journal Article
Publication date: 2019-07-30
scimago Q3
wos Q4
SJR: 0.306
CiteScore: 2.6
Impact factor: 1.4
ISSN: 1934578X, 15559475
Drug Discovery
General Medicine
Pharmacology
Complementary and alternative medicine
Plant Science
Abstract
The synthesis of A-azepanobetulinic acid N-methylpiperazinylamide was performed through a series of transformations (oximation, Beckmann rearrangement, reduction) of previously synthesized betulonic acid N-methylpiperazinylamide. In vitro cytotoxic activity was detected for the obtained compound against a number of cancer cell lines, and its potential was revealed as an antibacterial agent.
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Giniyatullina G. V. et al. Synthesis and сytotoxicity of a-azepanobetulinic acid N-methyl-piperazinylamide // Natural Product Communications. 2019. Vol. 14. No. 7. p. 1934578X1986067.
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Giniyatullina G. V., Kazakova O. B., Baikova I. P., Yamansarov E. Yu., Osterman I. A., Komarova E. S., Skvortsov D. A., Saltikova I. V., Majouga A. G., Ivanenkov Y. A. Synthesis and сytotoxicity of a-azepanobetulinic acid N-methyl-piperazinylamide // Natural Product Communications. 2019. Vol. 14. No. 7. p. 1934578X1986067.
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TY - JOUR
DO - 10.1177/1934578X19860670
UR - https://doi.org/10.1177/1934578X19860670
TI - Synthesis and сytotoxicity of a-azepanobetulinic acid N-methyl-piperazinylamide
T2 - Natural Product Communications
AU - Giniyatullina, Gulnara V
AU - Kazakova, Oxana B.
AU - Baikova, Irina P
AU - Yamansarov, Emil Yu
AU - Osterman, Ilya A.
AU - Komarova, Ekaterina S.
AU - Skvortsov, Dmitry A.
AU - Saltikova, Irina V
AU - Majouga, Alexander G.
AU - Ivanenkov, Yan A
PY - 2019
DA - 2019/07/30
PB - SAGE
SP - 1934578X1986067
IS - 7
VL - 14
SN - 1934-578X
SN - 1555-9475
ER -
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BibTex (up to 50 authors)
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@article{2019_Giniyatullina,
author = {Gulnara V Giniyatullina and Oxana B. Kazakova and Irina P Baikova and Emil Yu Yamansarov and Ilya A. Osterman and Ekaterina S. Komarova and Dmitry A. Skvortsov and Irina V Saltikova and Alexander G. Majouga and Yan A Ivanenkov},
title = {Synthesis and сytotoxicity of a-azepanobetulinic acid N-methyl-piperazinylamide},
journal = {Natural Product Communications},
year = {2019},
volume = {14},
publisher = {SAGE},
month = {jul},
url = {https://doi.org/10.1177/1934578X19860670},
number = {7},
pages = {1934578X1986067},
doi = {10.1177/1934578X19860670}
}
Cite this
MLA
Copy
Giniyatullina, Gulnara V., et al. “Synthesis and сytotoxicity of a-azepanobetulinic acid N-methyl-piperazinylamide.” Natural Product Communications, vol. 14, no. 7, Jul. 2019, p. 1934578X1986067. https://doi.org/10.1177/1934578X19860670.