Blood, volume 124, issue 17, pages 2705-2712

TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients

Rafael Bejar ¹

Allegra Lord ²

Kristen Stevenson ³

Michal Bar-Natan ⁴

Albert Perez Ladaga ¹

Jacques Zaneveld ⁵

Hui Wang ⁵

Bennett Caughey ¹

Petar Stojanov ⁶

Gad Getz ⁶

Guillermo Garcia-Manero ⁷

Hagop Kantarjian ⁷

Rui Chen ⁵

Richard M. Stone ⁴

DONNA NEUBERG ³

David P Steensma ⁴

Benjamin L. Ebert ^{2, 6}

Show full list: 17 authors

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Division of Hematology and Oncology, University of California San Diego Moores Cancer Center, La Jolla, CA; |

Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA;

Department of Biostatistics and Computational Biology and

⁴

Department of Medical Oncology, Division of Hematological Malignancies, Dana-Farber Cancer Institute, Boston, MA; |

⁵

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; |

⁶

Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA; and |

⁷

Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX |

Publication type: Journal Article

Publication date: 2014-10-23

American Society of Hematology

Journal: Blood

scimago Q1

SJR: 5.272

CiteScore: 23.6

Impact factor: 21

ISSN: 00064971, 15280020

DOI: 10.1182/blood-2014-06-582809

Copy DOI

Biochemistry

Cell Biology

Immunology

Hematology

Abstract

Key Points

Higher abundance TET2 mutations are associated with increased response to hypomethylating agents, particularly when ASXL1 is not mutated. TP53 and PTPN11 mutations are associated with shorter overall survival after hypomethylating agent treatment, but do not predict response.

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