Open Access

BMC Microbiology, volume 19, issue 1, publication number 309

Primary progressive multiple sclerosis in a Russian cohort: relationship with gut bacterial diversity

Kozhieva Madina ¹

Naumova Natalia ²

Alikina Tatiana ²

Boyko Alexey ^{1, 3}

Vlassov Valentin ²

Kabilov Marsel R ²

Hide authors affiliations Show authors affiliations: 3 affiliations

Department of Neurology, Neurosurgery and Medical Genetics of the Pirogov Medical University, Moscow, Russia |

Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia |

Department of Neuroimmunology of the Federal Center of CVPI, Moscow, Russia |

Publication type: Journal Article

Publication date: 2019-12-30

Springer Nature

Journal: BMC Microbiology

Quartile SCImago

Quartile WOS

Impact factor: 4.2

ISSN: 14712180

DOI: 10.1186/s12866-019-1685-2

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Microbiology (medical)

Microbiology

Abstract

Gut microbiota has been increasingly acknowledged to shape significantly human health, contributing to various autoimmune diseases, both intestinal and non-intestinal, including multiple sclerosis (MS). Gut microbiota studies in patients with relapsing remitting MS strongly suggested its possible role in immunoregulation; however, the profile and potential of gut microbiota involvement in patients with primary progressive MS (PPMS) patients has received much less attention due to the rarity of this disease form. We compared the composition and structure of faecal bacterial assemblage using Illumina MiSeq sequencing of V3-V4 hypervariable region of 16S rRNA genes amplicons in patients with primary progressive MS and in the healthy controls. Over all samples 12 bacterial phyla were identified, containing 21 classes, 25 orders, 54 families, 174 genera and 1256 operational taxonomic units (OTUs). The Firmicutes phylum was found to be ultimately dominating both in OTUs richness (68% of the total bacterial OTU number) and in abundance (71% of the total number of sequence reads), followed by Bacteroidetes (12 and 16%, resp.) and Actinobacteria (7 and 6%, resp.). Summarily in all samples the number of dominant OTUs, i.e. OTUs with ≥1% relative abundance, was 13, representing much less taxonomic richness (three phyla, three classes, four orders, six families and twelve genera) as compared to the total list of identified OTUs and accounting for 30% of the sequence reads number in the healthy cohort and for 23% in the PPMS cohort. Human faecal bacterial diversity profiles were found to differ between PPMS and healthy cohorts at different taxonomic levels in minor or rare taxa. Marked PPMS-associated increase was found in the relative abundance of two dominant OTUs (Gemmiger sp. and an unclassified Ruminococcaceae). The MS-related differences were also found at the level of minor and rare OTUs (101 OTUs). These changes in OTUs’ abundance translated into increased bacterial assemblage diversity in patients. The findings are important for constructing a more detailed global picture of the primary progressive MS-associated gut microbiota, contributing to better understanding of the disease pathogenesis.

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Citations by journals

	1 2 3
Frontiers in Immunology	Frontiers in Immunology, 3, 7.5% Frontiers in Immunology 3 publications, 7.5%
Medical academic journal	Medical academic journal, 3, 7.5% Medical academic journal 3 publications, 7.5%
Microorganisms	Microorganisms, 2, 5% Microorganisms 2 publications, 5%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 2, 5% International Journal of Molecular Sciences 2 publications, 5%
International Journal of Environmental Research and Public Health	International Journal of Environmental Research and Public Health, 1, 2.5% International Journal of Environmental Research and Public Health 1 publication, 2.5%
Brain Sciences	Brain Sciences, 1, 2.5% Brain Sciences 1 publication, 2.5%
Life	Life, 1, 2.5% Life 1 publication, 2.5%
Journal of Personalized Medicine	Journal of Personalized Medicine, 1, 2.5% Journal of Personalized Medicine 1 publication, 2.5%
Journal of Clinical Medicine	Journal of Clinical Medicine, 1, 2.5% Journal of Clinical Medicine 1 publication, 2.5%
Frontiers in Microbiology	Frontiers in Microbiology, 1, 2.5% Frontiers in Microbiology 1 publication, 2.5%
Frontiers in Neuroscience	Frontiers in Neuroscience, 1, 2.5% Frontiers in Neuroscience 1 publication, 2.5%
Current Treatment Options in Neurology	Current Treatment Options in Neurology, 1, 2.5% Current Treatment Options in Neurology 1 publication, 2.5%
Clinical Immunology	Clinical Immunology, 1, 2.5% Clinical Immunology 1 publication, 2.5%
Cell	Cell, 1, 2.5% Cell 1 publication, 2.5%
Neurologic Clinics	Neurologic Clinics, 1, 2.5% Neurologic Clinics 1 publication, 2.5%
Journal of Clinical Neuroscience	Journal of Clinical Neuroscience, 1, 2.5% Journal of Clinical Neuroscience 1 publication, 2.5%
Cell Reports Medicine	Cell Reports Medicine, 1, 2.5% Cell Reports Medicine 1 publication, 2.5%
Neuroscience and Biobehavioral Reviews	Neuroscience and Biobehavioral Reviews, 1, 2.5% Neuroscience and Biobehavioral Reviews 1 publication, 2.5%
European Journal of Immunology	European Journal of Immunology, 1, 2.5% European Journal of Immunology 1 publication, 2.5%
Annals of Neurology	Annals of Neurology, 1, 2.5% Annals of Neurology 1 publication, 2.5%
Brain Communications	Brain Communications, 1, 2.5% Brain Communications 1 publication, 2.5%
Brain	Brain, 1, 2.5% Brain 1 publication, 2.5%
Polish Journal of Microbiology	Polish Journal of Microbiology, 1, 2.5% Polish Journal of Microbiology 1 publication, 2.5%
Lecture Notes in Computer Science	Lecture Notes in Computer Science, 1, 2.5% Lecture Notes in Computer Science 1 publication, 2.5%
Frontiers in Cellular and Infection Microbiology	Frontiers in Cellular and Infection Microbiology, 1, 2.5% Frontiers in Cellular and Infection Microbiology 1 publication, 2.5%
Scientific Reports	Scientific Reports, 1, 2.5% Scientific Reports 1 publication, 2.5%
Gut Microbes	Gut Microbes, 1, 2.5% Gut Microbes 1 publication, 2.5%
Nevrologiya, Neiropsikhiatriya, Psikhosomatika	Nevrologiya, Neiropsikhiatriya, Psikhosomatika, 1, 2.5% Nevrologiya, Neiropsikhiatriya, Psikhosomatika 1 publication, 2.5%
Journal of clinical practice	Journal of clinical practice, 1, 2.5% Journal of clinical practice 1 publication, 2.5%

	1 2 3

Citations by publishers

	1 2 3 4 5 6 7 8 9
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 9, 22.5% Multidisciplinary Digital Publishing Institute (MDPI) 9 publications, 22.5%
Frontiers Media S.A.	Frontiers Media S.A., 6, 15% Frontiers Media S.A. 6 publications, 15%
Elsevier	Elsevier, 6, 15% Elsevier 6 publications, 15%
Eco-Vector LLC	Eco-Vector LLC, 4, 10% Eco-Vector LLC 4 publications, 10%
Springer Nature	Springer Nature, 3, 7.5% Springer Nature 3 publications, 7.5%
Wiley	Wiley, 2, 5% Wiley 2 publications, 5%
Oxford University Press	Oxford University Press, 2, 5% Oxford University Press 2 publications, 5%
Polskie Towarzystwo Mikrobiologow/Polish Society of Microbiologists	Polskie Towarzystwo Mikrobiologow/Polish Society of Microbiologists, 1, 2.5% Polskie Towarzystwo Mikrobiologow/Polish Society of Microbiologists 1 publication, 2.5%
Taylor & Francis	Taylor & Francis, 1, 2.5% Taylor & Francis 1 publication, 2.5%
IMA Press, LLC	IMA Press, LLC, 1, 2.5% IMA Press, LLC 1 publication, 2.5%
Pleiades Publishing	Pleiades Publishing, 1, 2.5% Pleiades Publishing 1 publication, 2.5%
	1 2 3 4 5 6 7 8 9

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Kozhieva M. et al. Primary progressive multiple sclerosis in a Russian cohort: relationship with gut bacterial diversity // BMC Microbiology. 2019. Vol. 19. No. 1. 309

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Kozhieva M., Naumova N., Alikina T., Boyko A., Vlassov V., Kabilov M. R. Primary progressive multiple sclerosis in a Russian cohort: relationship with gut bacterial diversity // BMC Microbiology. 2019. Vol. 19. No. 1. 309

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TY - JOUR

DO - 10.1186/s12866-019-1685-2

UR - https://doi.org/10.1186%2Fs12866-019-1685-2

TI - Primary progressive multiple sclerosis in a Russian cohort: relationship with gut bacterial diversity

T2 - BMC Microbiology

AU - Kozhieva, Madina

AU - Naumova, Natalia

AU - Alikina, Tatiana

AU - Boyko, Alexey

AU - Vlassov, Valentin

AU - Kabilov, Marsel R

PY - 2019

DA - 2019/12/30 00:00:00

PB - Springer Nature

IS - 1

VL - 19

SN - 1471-2180

ER -

BibTex

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BibTex Copy

@article{2019_Kozhieva,

author = {Madina Kozhieva and Natalia Naumova and Tatiana Alikina and Alexey Boyko and Valentin Vlassov and Marsel R Kabilov},

title = {Primary progressive multiple sclerosis in a Russian cohort: relationship with gut bacterial diversity},

journal = {BMC Microbiology},

year = {2019},

volume = {19},

publisher = {Springer Nature},

month = {dec},

url = {https://doi.org/10.1186%2Fs12866-019-1685-2},

number = {1},

doi = {10.1186/s12866-019-1685-2}

}

Found error?

Publisher

Springer Nature

Journal

BMC Microbiology

Quartile SCImago

Quartile WOS

Impact factor

4.2

ISSN

14712180 (Print)

Labs

CCP "Genomics"

Profiles

Kabilov, Marsel Rasimovich