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Open access
Journal of Translational Medicine, volume 22, issue 1, publication number 293

Potential anti-tumor effects of regulatory T cells in the tumor microenvironment: a review

Yu Li 1
Cangang Zhang 2
Aimin Jiang 3
Anqi Lin 1
Zaoqu Liu 4, 5
Xiangshu Cheng 6
Wanting Wang 7
Quan Cheng 8
Jian Zhang 1
TING WEI 1
Peng Luo 1
Show full list: 11 authors
Publication typeJournal Article
Publication date2024-03-20
scimago Q1
wos Q1
SJR1.611
CiteScore10.0
Impact factor6.1
ISSN14795876
General Biochemistry, Genetics and Molecular Biology
General Medicine
Abstract

Regulatory T cells (Tregs) expressing the transcription factor FoxP3 are essential for maintaining immunological balance and are a significant component of the immunosuppressive tumor microenvironment (TME). Single-cell RNA sequencing (ScRNA-seq) technology has shown that Tregs exhibit significant plasticity and functional diversity in various tumors within the TME. This results in Tregs playing a dual role in the TME, which is not always centered around supporting tumor progression as typically believed. Abundant data confirms the anti-tumor activities of Tregs and their correlation with enhanced patient prognosis in specific types of malignancies. In this review, we summarize the potential anti-tumor actions of Tregs, including suppressing tumor-promoting inflammatory responses and boosting anti-tumor immunity. In addition, this study outlines the spatial and temporal variations in Tregs function to emphasize that their predictive significance in malignancies may change. It is essential to comprehend the functional diversity and potential anti-tumor effects of Tregs to improve tumor therapy strategies.

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