Open Access

Biology Direct

, volume 18 , issue 1 , publication number 67

Nuclear respiratory factor 1 drives hepatocellular carcinoma progression by activating LPCAT1-ERK1/2-CREB axis

Ran Liu ¹

Chuanzheng Yin ¹

Peng Zhao ¹

Bing Guo ²

Wenbo Ke ¹

Xichuan Zheng ¹

Dawei Xie ³

Yaofeng Wang ¹

Gengqiao Wang ¹

Yinzhao Jia ¹

Yang Gao ¹

Wenjun Hu ⁴

Gang Logan Liu ⁴

Zifang Song ¹

Hide authors affiliations Show authors affiliations: 4 affiliations

Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, China |

Insitute for Genome Sciences, University of Maryland School of Medical, Baltimore, USA |

State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China |

⁴

School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China |

Publication type: Journal Article

Publication date: 2023-10-24

Springer Nature

Biology Direct

scimago Q1

wos Q1

SJR: 1.199

CiteScore: 5.0

Impact factor: 4.9

ISSN: 17456150

DOI: 10.1186/s13062-023-00428-z

Copy DOI

PubMed ID: 37875967

General Biochemistry, Genetics and Molecular Biology

General Agricultural and Biological Sciences

Immunology

Ecology, Evolution, Behavior and Systematics

Applied Mathematics

Modeling and Simulation

Abstract

Background

Nuclear respiratory factor 1 (NRF1) is a transcription factor that participates in several kinds of tumor, but its role in hepatocellular carcinoma (HCC) remains elusive. This study aims to explore the role of NRF1 in HCC progression and investigate the underlying mechanisms.

Results

NRF1 was overexpressed and hyperactive in HCC tissue and cell lines and high expression of NRF1 indicated unfavorable prognosis of HCC patients. NRF1 promoted proliferation, migration and invasion of HCC cells both in vitro and in vivo. Mechanistically, NRF1 activated ERK1/2-CREB signaling pathway by transactivating lysophosphatidylcholine acyltransferase 1 (LPCAT1), thus promoting cell cycle progression and epithelial mesenchymal transition (EMT) of HCC cells. Meanwhile, LPCAT1 upregulated the expression of NRF1 by activating ERK1/2-CREB signaling pathway, forming a positive feedback loop.

Conclusions

NRF1 is overexpressed in HCC and promotes HCC progression by activating LPCAT1-ERK1/2-CREB axis. NRF1 is a promising therapeutic target for HCC patients.

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GOST Copy

Liu R. et al. Nuclear respiratory factor 1 drives hepatocellular carcinoma progression by activating LPCAT1-ERK1/2-CREB axis // Biology Direct. 2023. Vol. 18. No. 1. 67

GOST all authors (up to 50) Copy

Liu R., Yin C., Zhao P., Guo B., Ke W., Zheng X., Xie D., Wang Y., Wang G., Jia Y., Gao Y., Hu W., Liu G. L., Song Z. Nuclear respiratory factor 1 drives hepatocellular carcinoma progression by activating LPCAT1-ERK1/2-CREB axis // Biology Direct. 2023. Vol. 18. No. 1. 67

RIS |

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RIS Copy

TY - JOUR

DO - 10.1186/s13062-023-00428-z

UR - https://doi.org/10.1186/s13062-023-00428-z

TI - Nuclear respiratory factor 1 drives hepatocellular carcinoma progression by activating LPCAT1-ERK1/2-CREB axis

T2 - Biology Direct

AU - Liu, Ran

AU - Yin, Chuanzheng

AU - Zhao, Peng

AU - Guo, Bing

AU - Ke, Wenbo

AU - Zheng, Xichuan

AU - Xie, Dawei

AU - Wang, Yaofeng

AU - Wang, Gengqiao

AU - Jia, Yinzhao

AU - Gao, Yang

AU - Hu, Wenjun

AU - Liu, Gang Logan

AU - Song, Zifang

PY - 2023

DA - 2023/10/24

PB - Springer Nature

IS - 1

VL - 18

PMID - 37875967

SN - 1745-6150

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2023_Liu,

author = {Ran Liu and Chuanzheng Yin and Peng Zhao and Bing Guo and Wenbo Ke and Xichuan Zheng and Dawei Xie and Yaofeng Wang and Gengqiao Wang and Yinzhao Jia and Yang Gao and Wenjun Hu and Gang Logan Liu and Zifang Song},

title = {Nuclear respiratory factor 1 drives hepatocellular carcinoma progression by activating LPCAT1-ERK1/2-CREB axis},

journal = {Biology Direct},

year = {2023},

volume = {18},

publisher = {Springer Nature},

month = {oct},

url = {https://doi.org/10.1186/s13062-023-00428-z},

number = {1},

pages = {67},

doi = {10.1186/s13062-023-00428-z}

}

Publisher

Springer Nature

Journal

Biology Direct

scimago Q1

wos Q1

SJR

1.199

CiteScore

5.0

Impact factor

4.9

ISSN

17456150 (Print, Electronic)

Profiles

Wenjun Hu